Isicwangciso soMkhuseli weNoveli siphucula uKhuseleko kunye nokusebenza ngokuFanelekileyo koNyango lwe-CAR-T kwi-Acute B Cell Leukemia
EBeijing, eTshayina – nge-23 kaJulayi 2024- Kuphuhliso lwehlabathi, iSibhedlele saseLu Daopei, ngokubambisana noHebei Senlang Biotechnology, uye watyhila iziphumo ezithembisayo ezivela kuphando lwabo lwamva nje malunga ne-chimeric antigen receptor T (CAR-T) unyango lweseli. Olu pho nonongo, olujolise ekusebenzeni nasekukhuselekeni kweeseli ze-CAR-T ezenziwe ngabakhuthazi abahlukeneyo, kubonisa ukuqhubela phambili okubonakalayo kunyango lwe-acute B cell leukemia (B-ALL).
Uphononongo, olunesihloko esithi "Usetyenziso lwePromoter Regulating Surface Density of CAR Molecules May Modulate the Kinetics of CAR-T Cells In Vivo," ihlola indlela ukhetho lomgqugquzeli olunokuchaphazela ngayo ukusebenza kweeseli ze-CAR-T. Abaphandi uJin-Yuan Ho, uLin Wang, uYing Liu, uMin Ba, uJunfang Yang, uXian Zhang, uDandan Chen, uPeihua Lu, kunye noJianqiang Li baseHebei Senlang Biotechnology kunye neSibhedlele saseLu Daopei bakhokela olu phando.
Iziphumo zabo zibonisa ukuba ukusebenzisa i-MND (intsholongwane ye-myeloproliferative sarcoma i-MPSV isiphuculi, ummandla wolawulo olubi ukucinywa kwe-NCR, i-d1587rev primer ebopha indawo yokubuyisela indawo) umxhasi kwiiseli ze-CAR-T kukhokelela ekuxininiseni okusezantsi kweemolekyuli ze-CAR, ezithi zinciphise imveliso ye-cytokine. Oku kubalulekile kuba kunceda ukunciphisa iziphumo ezibi kakhulu ezihlala zihambelana nonyango lwe-CAR-T, njenge-cytokine release syndrome (CRS) kunye ne-CAR-T cell-related encephalopathy syndrome (CRES).
Ulingo lweklinikhi, olubhaliswe phantsi kwe-ClinicalTrials.gov isazisi i-NCT03840317, ibandakanya izigulane ze-14 ezahlulwe zibe ngamaqela amabini: enye ifumana iiseli ze-CAR-T eziqhutywa yi-MND kwaye enye ifumana iiseli ze-CAR-T eziqhutywa ngumgqugquzeli we-EF1A. Okuphawulekayo kukuba, zonke izigulana eziphathwe nge-MND-driven CAR-T cells zafumana ukuxolelwa okupheleleyo, kwaye uninzi lwazo lubonisa isimo esincinci se-residual-negative status emva kwenyanga yokuqala. Uphononongo luphinde luchaze iziganeko eziphantsi ze-CRS ezinzima kunye ne-CRES kwizigulane eziphathwa ngeeseli ze-CAR-T eziqhutywa yi-MND xa kuthelekiswa nezo ziphathwa ngeeseli eziqhutywa yi-EF1A.
UGqr Peihua Lu ovela kwiSibhedlele saseLu Daopei ubonise ithemba malunga nokuba khona kwale ndlela inoveli, esithi, "Intsebenziswano yethu ne-Hebei Senlang Biotechnology iye yavelisa ulwazi olubalulekileyo ekuphuculeni unyango lweseli ye-CAR-T. Ngokuhlengahlengisa umgqugquzeli, sinokuphucula iphrofayili yokhuseleko yonyango ngelixa igcina ukusebenza kwayo oku linyathelo elibalulekileyo eliya phambili ekwenzeni unyango lwe-CAR-T lufikeleleke kwaye lunyamezeleke kwizigulane.
Uphononongo luxhaswe ngenkxaso-mali evela kwiSiseko seNzululwazi yezeNzululwazi yePhondo laseHebei kunye neSebe lezeNzululwazi kunye neTekhnoloji yePhondo laseHebei. Ibonisa ukubaluleka kokukhethwa komgqugquzeli ekuphuhliseni unyango lweeseli ze-CAR-T kwaye luvula iindlela ezintsha zokunyanga umhlaza okhuselekileyo kunye nolusebenzayo.