Isu Lomgqugquzeli Unoveli Lithuthukisa Ukuphepha kanye Ukusebenza Ngempumelelo Kwe-CAR-T Therapy ku-Acute B Cell Leukemia
Beijing, China – Julayi 23, 2024- Ekuthuthukisweni okudabukisayo, isibhedlela i-Lu Daopei, ngokubambisana ne-Hebei Senlang Biotechnology, sembule imiphumela ethembisayo evela ocwaningweni lwabo lwakamuva lwe-chimeric antigen receptor T (CAR-T) cell therapy. Lolu cwaningo, olugxile ekusebenzeni kahle nasekuphepheni kwamaseli e-CAR-T akhiwe ngabagqugquzeli abahlukene, luphawula inqubekelaphambili ebalulekile ekwelapheni kwe-acute B cell leukemia (B-ALL) ebuyele emuva noma ephikisayo.
Ucwaningo, olunesihloko esithi "Ukusetshenziswa Kophromotha Okulawula Ukuminyana Okungaphezulu Kwama-Molekyuli E-CAR Angase Alinganise I-Kinetics Yamaseli E-CAR-T Ku-Vivo," luhlola ukuthi ukukhetha komphromotha kungathonya kanjani ukusebenza kwamaseli e-CAR-T. Abacwaningi u-Jin-Yuan Ho, uLin Wang, u-Ying Liu, uMin Ba, uJunfang Yang, u-Xian Zhang, uDandan Chen, u-Peihua Lu, no-Jianqiang Li base-Hebei Senlang Biotechnology kanye ne-Lu Daopei Hospital abahole kulolu cwaningo.
Ukuthola kwabo kubonisa ukuthi ukusebenzisa isithuthukisi se-MND (i-myeloproliferative sarcoma virus MPSV, ukususwa kwesifunda sokulawula okungekuhle kwe-NCR, ukushintshwa kwesayithi okubopha i-d1587rev primer) kumaseli e-CAR-T kuholela ekwehleni kokuminyana komhlaba kwama-molecule e-CAR, okubuye kunciphise ukukhiqizwa kwe-cytokine. Lokhu kubalulekile ngoba kusiza ekwehliseni imiphumela emibi kakhulu evame ukuhlotshaniswa nokwelashwa kwe-CAR-T, njenge-cytokine release syndrome (CRS) kanye ne-CAR-T cell-related encephalopathy syndrome (CRES).
Ukuhlolwa komtholampilo, okubhaliswe ngaphansi kwesihlonzi se-ClinicalTrials.gov NCT03840317, kufake iziguli ezingu-14 ezihlukaniswe ngamaqoqo amabili: eyodwa ethola amaseli e-CAR-T ashayelwa yi-MND kanti enye ithola amaseli e-CAR-T aqhutshwa ngumgqugquzeli we-EF1A. Ngokuphawulekayo, zonke iziguli ezelashwa ngamaseli e-CAR-T aqhutshwa yi-MND zithole ukukhululwa okuphelele, iningi lazo libonisa isimo esincane sensalela sokungabi nezifo ngemva kwenyanga yokuqala. Ucwaningo luphinde lwabika isigameko esiphansi se-CRS ne-CRES enzima ezigulini eziphathwa ngamaseli e-CAR-T aqhutshwa yi-MND uma kuqhathaniswa nalawo aphathwa ngamaseli aqhutshwa yi-EF1A.
UDkt. Peihua Lu wasesibhedlela i-Lu Daopei uzwakalise ukuba nethemba ngamandla ale noveli, wathi, “Ukubambisana kwethu ne-Hebei Senlang Biotechnology kuveze imininingwane ebalulekile ekuthuthukiseni ukwelashwa kwamaseli e-CAR-T. Ngokulungisa umgqugquzeli, singathuthukisa iphrofayela yezokuphepha. yokwelashwa ngenkathi igcina ukusebenza kwayo. Lesi isinyathelo esibalulekile esiya phambili ekwenzeni ukwelashwa kwe-CAR-T kufinyeleleke futhi kubekezeleleke ezigulini.
Ucwaningo lusekelwe izibonelelo ezivela ku-Natural Science Foundation yesiFundazwe sase-Hebei kanye noMnyango Wezesayensi Nobuchwepheshe WesiFundazwe sase-Hebei. Igqamisa ukubaluleka kokukhetha abagqugquzeli ekuthuthukisweni kwezindlela zokwelapha zamaseli e-CAR-T futhi ivula izindlela ezintsha zokwelapha umdlavuza ophephile futhi osebenza kangcono.