- Ọgwụgwọ
- Akaebe
- Neuroblastoma
- Tumor siri ike
- Akaebe
- TILS
- NK Cell Therapy
- Myasthenia Gravis (MG)
- Nnukwu ọrịa leukemia Lymphoblastic (B-ALL)
- Lupus Erythematosus System (SLE)
- Nnukwu ọrịa leukemia Lymphoblastic (T-ALL)
- Na-abụghị Hodgkin Lymphoma (NHL)
- Multiple Myeloma (MM)
- Na-ekesa nnukwu Lymphom B-cell
- B-lymphocytic leukemia
- Myeloma
Nusinersen Sodium Injection: Olileanya maka Atrophy Muscular Spinal
Ka o si arụ ọrụ
Ngwọta nke sodiumbụ ọgwụ antisense oligonucleotide (ASO) nke na-elekwasị anya na mkpụrụ ndụ SMN2.
Site n'ịgbanwe usoro nhazi ya, ọ na-akwalite mmepụta nke arụ ọrụ SMN protein, dị mkpa maka ndụ neuron moto na ọrụ.
A na-enye ọgwụ ahụ ozugbo n'ime mmiri cerebrospinal site na nkwụsịtụ lumbar, na-eme ka ọ rute ebe ndị emetụtara nke ọma.
Uru ụlọ ọgwụ
SMA Ụdị I:
- Na-abawanye ọnụego nlanarị afọ 2 site na akụkọ ihe mere eme 50% ruo ihe karịrị 80%.
- Na-akwalite ọrụ moto dị ka ịnọdụ ọdụ na njikwa isi.
- Na-ebelata ịdabere na ikuku ventilashị.
SMA Ụdị II na III:
- Na-ebelata ọganihu ọrịa.
- Na-edobe ma ọ bụ na-emezi mmegharị aka na ọrụ iku ume.
- Ọgwụgwọ tupu mgbaàmà (dịka ọmụmaatụ, n'ime ụmụ amụrụ ọhụrụ) nwere ike ibute mmepe moto dị nso.
Mmetụta Ogologo Ogologo:
- Ihe nlebanya afọ ise na-egosi nkwalite ọrụ moto kwụsiri ike na-enweghị nnukwu ọdịda.
Nweta zuru ụwa ọnụ:
- Kemgbe nkwado FDA na 2016, ihe karịrị ndị ọrịa 100,000 gafee mba 60+ eritela uru, na-ekpuchi ụdị SMA niile.
Ihe akaebe sitere na nyocha
Nnwale ụlọọgwụ (dịka, EMBRACE, ENDEAR, CHERISH) metụtara Ndị ọrịa 274 gosi mgbanwe dị ịrịba ama:
- Nzaghachi ihe mberede ụgbọ ala: 51% dị mma karịa otu njikwa (p
- Nkwalite akara HINE-2: 26% dị mma karịa njikwa (p
Nnyocha e mere na ndị nọ n'afọ iri na ụma na ndị okenye na-egosikwa akara ọrụ moto emelitere (dịka, HFMSE, RULM) ka ọnwa 26 gachara.
Ọnụ ahịa na BIOOCUS
IUsoro ọgwụgwọ nitial (Injections 4): $200,000 ngwugwu zuru oke, gụnyere:
- Ọnụ ọgwụ: $50,000 kwa ntụtụ.
- Ụgwọ ịgba ọgwụ, ward, na ụgwọ nyocha.
- Nyefe ọdụ ụgbọ elu yana ọrụ njem ụgbọ mmiri oyi.
Mgbe ọgwụgwọ gasịrị: Ndị ọrịa nwere ike iburu ọgwụ nke anọ n'ụlọ n'ime igbe oyi oyi 2-8 Celsius ma nata nkwado maka mmezi mmezi kwa ọnwa 4 ọ bụla.
INtụle ọnụ ọnụ mba ụwa
| Obodo/ Mpaghara | Ọnụ maka ịgba ọgwụ (USD) | Mkpokọta maka 4 na-ebunye doses (USD) | Ọnụ ego nke afọ mbụ (USD) | Ihe ndetu |
| BIOOCUS, China | 50,000 | 200,000 | 200,000 (nke mbụ) | Na-agụnye ọrụ zuru ezu |
| United States | 125,000 | 500,000 | 750,000 (ntụtụ isii) | Enweghị enyemaka |
| Ọstrelia | 87,500 (enweghị enyemaka) | 350,000 | 525,000 (ntụtụ isii) | Enyere PBS aka
|
Nchekwa: Ọnụ ahịa BIOOCUS na-enye mbelata ọnụ ahịa ihe ruru 60% ma e jiri ya tụnyere ọnụego akwụghị ụgwọ na US na Australia.
Nlekọta zuru oke maka ndị ọrịa mba ụwa
Anyị na-enye nkwado pụrụ iche maka ndị ọrịa mba ụwa na-achọ ọgwụgwọ na China, na-eme ka ahụmihe na-adịghị mma ma dị mma.
Tupu ọgwụgwọ
- Ndụmọdụ ahụike: Atụmatụ ọgwụgwọ ahaziri onwe ya dabere na ndekọ ndị ọrịa.
- Otu ọkachamara: Nyocha multidisciplinary maka nkenke.
- Logistics: Enyemaka Visa, nhazi nkwụnye ego, na nhazi ụgbọ elu.
N'oge Ọgwụgwọ
- Ụlọ & Njem: A haziri ọnụ ụlọ nkwari akụ na nnyefe ọdụ ụgbọ elu.
- Nlekọta ahụike: Ọgwụgwọ na China Nuclear Medical Health Management Center, na-egosipụta teknụzụ dị elu na ndị ọrụ nwere nkà.
- Usoro ịgba ọgwụ: A na-elekọta ya na ụbọchị 1, 14, na 28, yana nlele 6-hour post-injections maka nchekwa.
Mgbe ọgwụgwọ gasịrị
- Were-n'ụlọ dose: Ngwunye nke anọ a na-enye n'ime igbe oyi oyi.
- Nkwado na-aga n'ihu: Enyemaka na usoro mmezi kwa ọnwa 4, gụnyere ịzụ ahịa na mbupu.
Ọrụ ndị ọzọ
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