KARATUN LAMURAN DA KE YANZU
CAR-T don Glioblastoma
Glioblastoma yana ɗaya daga cikin manyan ciwace-ciwacen kwakwalwa da suka fi yawa kuma masu ƙalubale a cikin manya. Yana samo asali ne daga ƙwayoyin glial a cikin kwakwalwa kuma an san shi da saurin girma da kuma saurin shiga cikin kyallen da ke kewaye, wanda hakan ke sa cirewa gaba ɗaya ya zama da wahala. Alamomin na iya haɗawa da ciwon kai, farfadiya, canje-canje a fahimta, da ƙarancin jijiyoyi, ya danganta da wurin da ciwon yake. Duk da cewa jiyya ta yau da kullun na iya taimakawa wajen magance cutar, marasa lafiya da yawa suna neman hanyoyin magancewa don inganta sakamako da ingancin rayuwa.
Maganin CAR-T don Ciwon Ciki
Maganin ƙwayoyin CAR-T wani maganin rigakafi ne na musamman wanda ake amfani da shi sosai don magance ciwon daji na ciki. BIOOCUS ya ƙirƙiro samfuran CAR-T waɗanda ke niyya ga ƙwayoyin rigakafi na musamman na ciwon ciki kamar Claudin18.2 da HER2, wanda ke nuna tasiri mai mahimmanci ga marasa lafiya waɗanda suka gaza jiyya da yawa a baya - misali, CT041 ya sami ORR na 57.1%, DCR na 75%, da kuma jimlar rayuwa na watanni 6 na 81.2%. Ta hanyar amfani da dandamalin GMP na duniya, ƙungiyar ƙwararru masu fannoni daban-daban, da kuma ƙwarewar asibiti mai yawa a duniya, BIOOCUS yana ba da mafita mai aminci, tasiri, da cikakken maganin CAR-T ga marasa lafiya da ke fama da ciwon daji na ciki.
CAR-T don Lupus Erythematosus na Tsari (SLE)
Maganin ƙwayoyin CAR-T (Chimeric Antigen Receptor T) wani sabon tsarin rigakafi ne wanda ya nuna yuwuwar magance SLE ta hanyar kai hari ga ƙwayoyin B, waɗanda ke taka muhimmiyar rawa a cikin cutar. A cikin SLE, ƙwayoyin B suna samar da ƙwayoyin rigakafi masu kai hari ga kyallen jiki, wanda ke haifar da kumburi na yau da kullun da lalacewar gabobi. Maganin CAR-T yana aiki ta hanyar injiniyan ƙwayoyin T don bayyana mai karɓa (CAR) wanda ke kai hari musamman ga CD19, alamar da ke kan ƙwayoyin B, wanda ke haifar da lalata waɗannan ƙwayoyin B masu cutarwa.
Kwayoyin CAR-T da ke kai hari ga ƙwayoyin CD19+ B suna samar da raguwar ƙwayoyin B mafi inganci da dorewa idan aka kwatanta da sauran hanyoyin magani, waɗanda ke kai hari ga CD20 amma sun kasa kawar da ƙwayoyin plasma masu daɗewa. Wannan raguwar ƙwayoyin B mai zurfi na iya haifar da sassaucin alamun SLE ta hanyar kawar da ƙwayoyin da ke da alhakin samar da ƙwayoyin rigakafi na autoantibody. Nazarin kuma ya binciki ƙwayoyin CAR-Treg (ƙwayoyin CAR-T da aka tsara don daidaita martanin garkuwar jiki) don dawo da juriyar garkuwar jiki da rage ayyukan garkuwar jiki.
FUCASO: Maganin Juyin Juya Hali na BCMA CAR-T Mai Cikakken Juyin Juya Hali tare da Inganci da Tsaro Mara Daidaitawa
FUCASO magani ne mai juyi wanda BCMA ke jagoranta wanda IASO BIO ke jagoranta, wanda ke ba da inganci da aminci ga myeloma mai yawa da ya sake dawowa ko ya yi tsauri. Tare da yawan amsawa mai yawa, sassauci mai ɗorewa, da kuma ingantaccen bayanin tsaro, FUCASO yana ba da sabon bege ga marasa lafiya kuma yana kafa sabon ma'auni a cikin maganin CAR-T.
Cikakken Bayani Kan Maganin Cutar Leukemia Mai Muhimmanci
Maganin CAR-T, wanda aka yi wa lakabi da Chimeric Antigen Receptor T-Cell Immunotherapy, wata hanya ce ta zamani ta maganin kwayoyin halitta wadda ta ƙunshi gyara ƙwayoyin T na majiyyaci don kai hari da kuma lalata ƙwayoyin cutar kansa. Ba kamar magungunan gargajiya ba, maganin CAR-T an tsara shi ne ga kowane majiyyaci kuma yana buƙatar tattara ƙwayoyin T daga jinin majiyyaci kafin a sake haɗa su cikin jiki bayan injiniyan kwayoyin halitta.