ZVIDZIDZO ZVEMHOSVA ZVAZVIRIPO
CAR-T yeGlioblastoma
Glioblastoma ndeimwe yekenza dzepfungwa dzinonyanya kuomera vanhu vakuru. Inobva mumasero emuuropi uye inozivikanwa nekukura kwayo nekukurumidza uye tsika yekupinda munyama dzakapoteredza, zvichiita kuti kubviswa kwayo kuome. Zviratidzo zvinogona kusanganisira musoro, pfari, shanduko dzepfungwa, uye kusagadzikana kwetsinga, zvichienderana nenzvimbo yekenza. Kunyange zvazvo kurapwa kwakajairika kuchigona kubatsira kudzora chirwere ichi, varwere vazhinji vanotsvaga mishonga yakanangana nayo kuti vavandudze mhedzisiro uye hupenyu hwavo.
Kurapa kweCAR-T kweKenza yeMudumbu
Kurapa nemasero eCAR-T inzira yemazuva ano yekurapa kenza yemudumbu. BIOOCUS yakagadzira zvigadzirwa zveCAR-T zvakanangana nemaantigen ekenza yemudumbu akadai seClaudin18.2 neHER2, zvichiratidza kushanda zvakanaka muvarwere vakakundikana kurapwa kakawanda kare—semuenzaniso, CT041 yakawana ORR ye57.1%, DCR ye75%, uye mwero wekurarama kwemwedzi mitanhatu we81.2%. Ichishandisa puratifomu yepasi rose yeGMP, timu yenyanzvi dzakasiyana-siyana, uye ruzivo rwakakura rwekiriniki yepasi rose, BIOOCUS inopa mhinduro yakachengeteka, inoshanda, uye yakazara yekurapa kweCAR-T kune varwere vekenza yemudumbu.
CAR-T yeSystemic Lupus Erythematosus (SLE)
Kurapa nemasero eCAR-T (Chimeric Antigen Receptor T) inzira itsva yekurapa nekudzivirira muviri yakaratidza kugona kurapa SLE nekutarisa masero eB, ayo anoita basa rakakosha mukukura kwechirwere ichi. MuSLE, masero eB anogadzira maautoantibodies anorwisa nyama dzemuviri, zvichikonzera kuzvimba kusingaperi uye kukuvara kwenhengo. Kurapa neCAR-T kunoshanda nekugadzira masero eT kuratidza receptor (CAR) inonyanya kutarisa CD19, chiratidzo pamasero eB, zvichikonzera kuparadzwa kwemasero aya eB anokuvadza.
Masero eCAR-T anotarisa masero eCD19+ B anopa masero eB anopera simba uye anogara kwenguva refu zvichienzaniswa nemamwe marapirwo, ayo anotarisa CD20 asi anotadza kubvisa masero eplasma anogara kwenguva refu. Kupera kwemasero eB kwakadzama uku kunogona kutungamira mukuderedzwa kwezviratidzo zveSLE nekubvisa masero ane chekuita nekugadzirwa kweautoantibodies. Zvidzidzo zvinoongororawo CAR-Treg (masero eCAR-T akagadzirirwa kudzora mhinduro dzemuviri) kuti adzorere kushivirira kwemuviri uye kuderedza mashandiro emuviri.
FUCASO: Kurapa kweBCMA CAR-T kweVanhu Vakazara Nesimba Risina Kuenzana uye Kuchengetedzeka
FUCASO mushonga wekurapa weCAR-T unoshandiswa neIASO BIO, unoshanda zvakanaka uye wakachengeteka kune myeloma yakawanda inodzoka kana kuti isingadzoreki. Nekupindura kwakanyanya, kuregererwa kwenguva refu, uye kuchengetedzeka kwakasimba, FUCASO inopa tariro itsva kuvarwere uye inoisa mwero mutsva mukurapa kweCAR-T.
Pfupiso Yakakwana yeKurapwa KweLeukemia Kunotyisa
CAR-T Therapy, muchidimbu zvinoreva Chimeric Antigen Receptor T-Cell Immunotherapy, inzira yepamusoro yekurapa majini inosanganisira kugadzirisa majini emurwere T masero kuti arwise uye aparadze masero egomarara. Kusiyana nemishonga yechinyakare, CAR-T therapy yakagadzirirwa murwere wega wega uye inoda kuunganidza T masero kubva muropa remurwere asati adzoserwa mumuviri mushure mekugadzirwa kwemajini.