Kurapa kweCAR-T kweNeuroblastoma Yakadzoka Pakarepo/Isingadzoreki
Nezvekurapa
Kurapa kweGD2 CAR-Timishonga itsva yekudzivirira muviri inoshandura majini emasero eT emurwere kuti aone uye arwise masero eneuroblastoma anoratidza GD2 antigen. Kurapa uku kwakagadzirirwa varwere vane neuroblastoma ine njodzi huru yekudzoka kana kuti isingadzoreki uye kwakaratidza mhedzisiro yakanaka mukuyedza.
Zvinodiwa Kuti Ukwanise Kuzviita
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Mamiriro Echirwere: Neuroblastoma ine njodzi huru ine chirwere chinoramba chiripo, chinodzokera shure, kana kuti chinoenderera mberi mushure mekurapwa kwekutanga.
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Zvimwe Zvinhu: Chirwere chemetastatic, kuwedzera kweMYCN, kana kuramba kurapwa kwakajairika.
Maitiro Ekurapa
Matanho Akakosha
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Kugadzirisa zvinhu: Kupera kwemasero eropa (lymphodepletion) usati waiswa mushonga.
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Kupinzwa: Kuongororwa nemazvo kwemasero eGD2-CAR-T (zvinokurudzirwa: masero eT ane CAR-positive 10×10^6/kg).
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Tevera: Kuongororwa kwemifananidzo nguva dzose (PET/CT, MRI) uye kuongororwa kwemapfupa mushure mekuiswa muropa.
Kushanda Nekuchengetedza
Mhedzisiro yeKliniki
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Mwero weMhinduro: 33% vakawana remission yakakwana (CR), nechiyero chemhinduro yose (CR+PR) che63%.
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Kupona: makore matatu ekurarama kwese (OS) kwe60% uye EFS isina zviitiko (EFS) ye36% pachiyero chinokurudzirwa.
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Nhoroondo Yekuchengetedza: Zviitiko zvakanyanya kuipa zvaive zveGrade 1-2 cytokine release syndrome inorapika (74%).
Sei Uchifanira Kusarudza Isu
Zvakanakira Zvedu
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MOTA yechizvarwa chechitatu: Dual co-stimulatory domains (CD28 + 4-1BB) inowedzera simba remasero eT uye kuramba aripo.
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Chinja Chekuchengetedza: Gene re iC9 rakabatanidzwa rinobvumira kudzora chepfu nekukurumidza kana zvichidikanwa.
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Rekodhi Yakaratidzwa: Akabudirira mukuyedzwa kwekiriniki neruzivo rwakasimba rwekutevera kwenguva refu.
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