Te Whakaora CAR-T mō te Neuroblastoma Hoki/Whakakeke

Te rongoā GD2 CAR-THe rongoā ārai mate auaha te rongoā ārai mate e whakarerekē ana i ngā pūtau-T o te tūroro kia mōhio ai, kia whakaeke ai hoki i ngā pūtau neuroblastoma e whakaatu ana i te ira GD2. He mea hanga motuhake tēnei rongoā mō ngā tūroro e pāngia ana e te neuroblastoma mōrearea nui kua hoki mai, kua ātete rānei ki te mate, ā, kua whakaatuhia he hua haumanu whai hua i roto i ngā whakamātautau.

• Tūnga o te MateNeuroblastoma mōrearea nui me te mate pumau, te mate hoki, te mate haere tonu rānei i muri i te maimoatanga raina tuatahi.

• Ngā Take TāpiriTe mate pūmau, te whakanui ake i te MYCN, te ātete rānei ki ngā maimoatanga tuku iho.

Ngā Hipanga Matua

1. Te whakarite i muaTe wehenga toto i mua i te werohanga.

2. Te whaowhiaTe ine tika o ngā pūtau GD2-CAR-T (e taunakitia ana: 10×10^6 ngā pūtau T CAR-pai/kg).

3. Whai muriAromatawai whakaahua auau (PET/CT, MRI) me te hinu wheua i muri i te werohanga.

Ngā Hua Hauora

• Te Auau Whakautu33% i tutuki te murunga katoa (CR), me te reiti urupare whānui (CR+PR) o te 63%.

• Te orangaKo te oranga whānui (OS) mō ngā tau 3 he 60% me te oranga kore-huihuinga (EFS) he 36% i te horopeta kua tūtohutia.

• Kōtaha HaumaruKo te nuinga o ngā pānga kino e kitea ana ko te mate tukunga cytokine taumata 1-2 (74%) i taea te whakahaere.

Ā Mātou Painga

• Waka Whakatipuranga TuatoruKa whakarei ake ngā rohe whakaoho-rua (CD28 + 4-1BB) i te kaha me te pumau o ngā pūtau-T.

• Pātene HaumaruMā te ira iC9 whakauru ka taea te whakahaere tere i te paitini mēnā e tika ana.

• He Rēkoata Whai Hua kua WhakamanahiaKua whakaatuhia te angitu i roto i ngā whakamātautau haumanu me ngā raraunga whai-ake roa pakari.