Ngā Kāwai Maimoatanga

Ngā Maimoatanga Matua

Te Whakaora i te Huaketo Oncolytic: Te Maimoatanga Matepukupuku Matatau

CAR-T mō te Glioblastoma

Werohanga Konutai Nusinersen: Te Tūmanako mō te Ngaronga o ngā Uaua Tuaiwi

Te Whakaora CAR-T mō te Mate Pukupuku o te Kōpū

Te Whakaora CAR-T mō te Neuroblastoma Hoki/Whakakeke

CAR-T mō te Lupus Erythematosus Pūnaha (SLE)

Te Mate Pūtau Hāri me te Thalassemia

He Tūmanako Hou te Whakaora Ira Auaha mō ngā Tūroro Pūtau Hāri me te Thalassemia

FUCASO: Te Whakaora BCMA CAR-T Tangata Katoa Hou me te Whai Huatanga me te Haumaru Kore e Taea te Whakakotahi

Te Whakamahi i ngā Pūtau NK: Te Whakatairanga i te Rongoā Matepukupuku ki tua atu i ngā Rohe

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He Tirohanga Whānui mō te Maimoatanga Hou mō te Leukemia

Ko te CAR-T Therapy, he whakarāpopototanga mō te Chimeric Antigen Receptor T-Cell Immunotherapy, he tikanga whakaora ira matatau e uru ana ki te whakarerekē ira i ngā pūtau-T o te tūroro hei arotahi me te whakangaro i ngā pūtau matepukupuku. He rerekē ki ngā rongoā tuku iho, he mea whakarite te whakaora CAR-T ki ia tūroro, ā, me kohi ngā pūtau-T mai i te toto o te tūroro i mua i te whakahokinga mai ki roto i te tinana i muri i te hangarau ira.

Whakapā mai

Ngā tohu o CAR-T

● Te mate pukupuku lymphoblastic whakapeka pūtau-B

●myeloma maha

●Te mate pukupuku toto mau tonu

●Te mate pukupuku kore-Hodgkin

●Te lymphoma pūtau-B nui horapa

●SLE（Lupus Erythematosus Pūnaha）

●Te mate pāwera

●Ētahi atu mate pūnaha ārai mate

He tino pai te mahi haumanu a CAR-T

Ngā tohu mō te CD19+20CAR-T: Ngā tūroro e pāngia ana e te lymphoma kore-pūtau-B a Hodgkin

Reiti CR kotahi marama	Te utu PR kotahi marama	Kotahi marama OR reiti	CRS≥3	CRES≥3
71.95%（59/82）	25.6（21/82）	97.55（80/82）	12.19%（10/82）	0

Ngā tohu mō te CD19+22CAR-T: Te maimoatanga o ngā tūroro mate pukupuku toto B-lymphocytic whakapeka kua hoki mai te CD19 me te uaua ki te mahi

Reiti CR kotahi marama	Te utu PR kotahi marama	Kotahi marama OR reiti	CRS≥3	CRES≥3
92.1%（35/38）	7.9%（3/38）	100%（38/38）	15.79%（6/38）	0

Ngā tohu mō te BCMACAR-T: Te maimoatanga o te myeloma maha kua hoki mai me te uaua ki te whakatika

Reiti CR kotahi marama	Te utu PR kotahi marama	Kotahi marama OR reiti	CRS≥3	CRES≥3
72.41%（21/29）	27.59%（8/29）	100%（29/29）	6.9%（2/29）	0

Ā Mātou Painga

● Maimoatanga WhaiaroKa whakaritea ia rongoā CAR-T ki te tūroro, kia tino whai kiko ai ngā putanga maimoatanga, kia whai hua ai hoki.

● Ngā Kōwhiringa Whāinga KanorauMe te whānuitanga o ngā antigens ūnga, tae atu ki te CD7, CD19, CD20, CD22, me te BCMA, ka tukuna e ā mātou hua CAR-T he whānuitanga kore e rite ki te rongoā i ngā mate pukupuku toto me ngā mate pūnaha ārai mate.

● Angitu Hauora Kua WhakamātauhiaKua whakaatuhia e ā mātou maimoatanga CAR-T te whai huatanga tino pai puta noa i ngā kēhi haumanu maha, me ngā reiti murunga me ngā kōtaha haumaru whakamiharo, e whakakaha ana i tō mātou tūranga hei kaiārahi i roto i te whakaora ārai mate.

● Te Whai Hua o te UtuHe painga whakataetae tā mātou e tuku ana me ngā maimoatanga kounga teitei i te utu e māmā ake ana ki te whakaritea ki ētahi atu hua CAR-T kei te mākete.

● Hangarau HouMā te whakamahi i ngā whanaketanga hou o te hangarau ira, ka whakaatuhia e ā mātou maimoatanga CAR-T te heke mai o te maimoatanga mate pukupuku me ngā mate pūnaha ārai mate.

● Tautoko Hauora TohungaKa whakaratohia e tā mātou tīma tākuta me ngā kairangahau mātau te manaaki whānui mai i te whakawhitiwhiti kōrero tuatahi ki te whakahaere i te rongoā me te whai i te maimoatanga.

E mōhiotia whānuitia ana ngā pūtau CAR-T mō tō rātou whai huatanga i roto i ngā tūroro kāore i aro ki ngā maimoatanga tuku iho pēnei i te chemotherapy, te whakawhitinga wheua wheua rānei. E whakaae ana te ao hauora ki te kaha hou o te rongoā CAR-T ki te whakarerekē i ngā putanga o ngā tūroro.

Ngā rangahau me ngā take e pā ana ki te rongoā CAR-T

1.Te Whakaora CAR-T mō te Lupus Erythematosus Pūnaha: He Whai Huatanga Whakamiharo i roto i ngā Take Tamariki

I whakaatuhia e tētahi take hou i te Hōhipera o te Whare Wānanga o Erlangen te whai huatanga o te rongoā pūtau CAR-T i roto i te rongoā i tētahi kōtiro 15-tau te pakeke me te mate lupus erythematosus pūnaha (SLE). Whai muri i te maha o ngā maimoatanga i rahua, i whiwhi a Uresa i tēnei rongoā auaha i te Pipiri 2023. I roto i ngā wiki e toru i muri i te rongoā, kua tino pai ake ōna tohu, ā, kua ora katoa, kua whakahokia mai hoki te mahi a te whatukuhu. Ko tēnei angitu te whakamahinga tuatahi o te rongoā CAR-T mō ngā mate pūnaha ārai mate o ngā tamariki, e whakaatu ana i tōna kaha ki te whakatutuki i te murunga mō te wā roa me te whakarerekē i ngā putanga o te tūroro. Kei te haere tonu ngā rangahau hei tūhura i ōna tono i roto i ngā āhuatanga ōrite.

https://www.bioocus.com/news/breakthrough-in-pediatric-autoimmune-disease-car-t-cell-therapy-cures-lupus-patient/

2. Te Whakaora CAR-T mō te Myeloma Maha: Kua Whakatutukihia te Whakamarietanga Nui

I kite a Bjørn Simensen, he tūroro 67-tau te pakeke nō Nōwei, i tētahi panonitanga whakamiharo i roto i tana pakanga ki te myeloma maha (IgG lambda, ISS-II) i muri i tana whiwhinga i te rongoā pūtau CAR-T. I te tuatahi i kitea ia i te tau 2017, i whai ia i ētahi tikanga chemotherapy, engari ka hoki anō ia i te tau 2021. Whai muri i ngā maimoatanga kore hua, i tukuna ia ki te Hōhipera Lu Daopei i te Hui-tanguru 2022, i reira i tohua ai ia mō te rongoā CAR-T. Whai muri i te tikanga whakatikatika i mua, i whakauruhia ana pūtau CAR-T. I te rā 28, i kitea e ngā whakamātautau whai muri kāore he pūtau plasma rerekē i roto i tana hinu wheua, he tohu tēnei i te whakatutukitanga nui i roto i tana maimoatanga.

https://www.bioocus.com/bj-rn-simensen-multiple-myeloma-igg-lambda-iss-ii-product/

3. Te Whakaora CD7 CAR-T mō te T-ALL me te LBL kua Hoki: He Whai Hua me ngā Hua Whakamiharo

E whakaatu ana ngā rangahau hou i te whai huatanga o te rongoā CD7 chimeric antigen receptor T-cell (CAR-T) me te whakawhitinga pūtau take hematopoietic allogeneic tuarua (HSCT) mō ngā tūroro e pāngia ana e te relapse T-cell acute lymphoblastic leukemia (T-ALL) me te lymphoblastic lymphoma (LBL). I whakahaerehia i te Hōhipera o Hebei Yanda Lu Daopei, i uru atu ki te rangahau te 16 ngā tūroro i whiwhi i te 100% iti rawa o te mate toenga (MRD)-kino i muri i te maimoatanga. Me te 75% o te reiti relapse katoa mō ngā whara extramedullary me te oranga whānui kotahi tau me te reiti oranga kore leukemia o te 58.5% me te 51.4%, ia, ka tukuna e tēnei huarahi auaha he tumanako hou mō te relapse roa i roto i ēnei mate pukupuku kaha.

https://www.bioocus.com/news/promising-outcomes-of-cd7-car-t-therapy-combined-with-second-transplant-in-relapsed-t-all-lbl-patien/

4. Te Whakaora CAR-T mō te Leukemia Lymphoblastic Koretake o te Pūtau-B: He Whai Huatanga Kore i Oti

E whakaatu ana tētahi rangahau hou i te whai huatanga tino pai o te rongoā pūtau-T chimeric antigen receptor-T (CAR-T) ki te rongoā i te mate pukupuku toto nui-pūtau-B (B-ALL). I whakahaerehia tahi me BIOOCUS me te Hōhipera o Lu Daopei, i whakaatuhia e te rangahau he maha ngā tūroro i whiwhi i te whakaoranga katoa, e whakanoho ana i te rongoā CAR-T hei kōwhiringa maimoatanga matua mō tēnei mate pukupuku toto kino. Ko ngā hua whai hua e whakaatu ana i te kaha whakarerekētanga o te rongoā CAR-T i roto i te oncology, e whakarato ana i te tumanako mō ngā tūroro me ngā whānau e pāngia ana e te B-ALL. I te haere tonu o te rangahau, kua whakaritea te rongoā CAR-T hei mahi nui i roto i te heke mai o te rongoā mate pukupuku.

https://www.bioocus.com/news/pioneering-car-t-therapy-in-b-cell-acute-lymphoblastic-leukemia-shows-unprecedented-efficacy/

Te Tukanga Whakaora CAR-T

1. Kohinga Pūtau-T:

I te tīmatanga, ka kohia e ngā tākuta ngā pūtau-T mai i te toto o te tūroro mā te whakamahi i tētahi tikanga e kiia nei ko te leukapheresis. E whā hāora te roa o tēnei tukanga, ā, i roto i tēnei tukanga ka wehea ngā pūtau toto mā e hiahiatia ana e te kaiwehe toto, ka whakahokia ngā wāhanga e toe ana ki te tinana o te tūroro.

2. Te Whakarerekētanga me te Whanuitanga Ira:

Ka tukuna ngā pūtau-T kua kohia ki tētahi taiwhanga hei whakarerekē ira. I tēnei taahiraa, ka hangaia ngā pūtau-T hei arotahi me te whakangaro i ngā pūtau matepukupuku. E 2-3 wiki pea te roa o tēnei tukanga. I roto i tēnei wā, ka whakahohehia ngā pūtau-T, ka whakawhānuihia hoki i roto i te taiwhanga hei whakarite i tō rātou whai huatanga ki te matepukupuku.

3. Te Werohanga Pūtau:

Kia oti ngā pūtau-T kua hangaia, ka whakahokia mai ki te tinana o te tūroro mā te werohanga uaua. Mā tēnei taahiraa ka taea e ngā pūtau ārai mate kua whakarerekētia te kite me te whakakore i ngā pūtau matepukupuku.

Tērā pea ka pāngia ngā tūroro e ngā pānga taha i te wā e rongoatia ana, ko te mea tino kitea ko te cytokine release syndrome (CRS), i puta mai i te urupare ārai mate i te wā e whakangaro ana i ngā pūtau matepukupuku. Ahakoa he kino te CRS, kua tino whakaitihia e ngā whanaketanga hauora ōna mōrearea.

Ko te huringa maimoatanga katoa, mai i te kohikohinga pūtau ki te werohanga, e 4-6 wiki te roa, engari ko te roa tika ka whakawhirinaki ki te āhua motuhake o te tūroro.

Tautoko Whānui mō ngā Tūroro o te Ao e Haere Ana ki BIOOCUS mō te Maimoatanga CAR-T

I BIOOCUS, e whakapau kaha ana mātou ki te whakarato i te manaaki me te tautoko tino pai mō ngā tūroro o te ao e rapu ana i te rongoā CAR-T. Ka hipokina e ā mātou ratonga whānui ia taahiraa o te haerenga, mai i ngā whakaritenga i mua i te haerenga ki te manaaki i muri i te maimoatanga.

1. Te Whakarite i mua i te Haerenga

I mua i te haerenga ki BIOOCUS, ka arotakehia ngā tūroro i mua i te whakamātautau hauora o tō rātou rohe. Kei roto i tēnei ko te arotakenga hōhonu o ngā hītori hauora, ngā whakamātautau tinana, me ngā whakamātautau e tika ana pērā i te mahi toto, ngā rangahau whakaahua, me ngā tirotiro e pā ana ki te momo mate pukupuku e rongoatia ana (pērā i te leukemia, te lymphoma, ētahi atu mate pukupuku toto rānei). Ka whakarite mātou kia tukuna ngā tuhinga hauora katoa, tae atu ki ngā maimoatanga o mua, ngā hua whakamātautau, me ngā whakaū tātaritanga, ki tā mātou tīma hei arotake me te whakarite.

2. Te Haere me te Noho Hōhipera

Ka āwhina mātou i ngā āhuatanga katoa o te haere, tae atu ki te whakarite wāhi noho me te tono tūroro ki te BIOOCUS International Medical Center. I te taenga atu, ka ārahihia ngā tūroro i roto i te tukanga whakaurunga, kia pai ai te whakawhiti ki te taiao maimoatanga.

3. Tukanga Maimoatanga

I te whakaurunga, ka whai whakamātautau tuatahi ngā tūroro, tae atu ki ngā aromatawai hei whakarite i te tika mō te rongoā CAR-T. Ka uru atu ki tēnei he arotake i te āhua o te mate pukupuku me te hauora whānui o te tūroro, tae atu ki te kohikohi toto mō te tango pūtau-T. Kātahi ka tukuna ngā pūtau-T kua kohia ki tā mātou taiwhanga kua whakamanahia e te GMP hei whakarerekē ira. E 2-3 wiki pea te roa o tēnei tukanga.

4. Te Werohanga Pūtau me te Tiaki i Muri i te Maimoatanga

Kia rite ngā pūtau CAR-T kua whakarerekētia, ka hoki ngā tūroro ki tō mātou hōhipera mō te tikanga werohanga. He maimoatanga kotahi tēnei, ka tukuna ngā pūtau-T kua hangaia mā roto i te uaua. Whai muri i te werohanga, ka noho tonu ngā tūroro i raro i te tirotiro tata mō ētahi rā hei aroturuki i ngā pānga taha, pērā i te mate tuku cytokine, he tauhohenga pea ki te maimoatanga. Ka tautoko tonu tā mātou tīma hauora me te aroturuki i tēnei wā tino nui.

I muri i te tukunga mai i te hōhipera, ka whakarite a BIOOCUS i ngā haerenga tirotiro auau, tae atu ki ngā whakamātautau taiwhanga me ngā rangahau whakaahua, hei aroturuki i te whai huatanga o te maimoatanga me te whai i te whakaoranga o te tūroro. Ka tirotirohia tata ngā tūroro mō ngā pānga tōmuri o te maimoatanga, ā, ka noho tonu tā mātou tīma ki te whakapā atu ki a rātou hei whakarato aratohu me te tautoko tonu.

I BIOOCUS, ko te hauora, te haumaru, me te whakamarie o ā mātou tūroro o tāwāhi te mea nui ki a mātou. Ko tā mātou whāinga he whakarato i te tiaki whānui me te whakarite i tētahi wheako tautoko, maeneene hoki puta noa i te haerenga maimoatanga CAR-T.

Mō ētahi atu kōrero e pā ana ki ā mātou ratonga, me pēhea hoki e taea ai e mātou te āwhina i a koe me tō maimoatanga, tēnā whakapā mai ki a mātou.

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