Magulu a Chithandizo

Mankhwala Odziwika

Chithandizo cha Kachilombo ka Oncolytic: Chithandizo Chapamwamba cha Khansa

CAR-T ya Glioblastoma

Jekeseni wa Nusinersen Sodium: Chiyembekezo cha Kufooka kwa Minofu ya Msana

Chithandizo cha CAR-T cha Khansa ya M'mimba

Chithandizo cha CAR-T cha Neuroblastoma Yobwerera M'mbuyo/Yosasinthika

CAR-T ya Systemic Lupus Erythematosus (SLE)

Matenda a Sickle Cell ndi Thalassemia

Chithandizo Chatsopano cha Majini Chimapereka Chiyembekezo Chatsopano kwa Odwala Matenda a Sickle Cell ndi Thalassemia

FUCASO: Chithandizo cha Revolutionary Fully-Human BCMA CAR-T chokhala ndi Mphamvu ndi Chitetezo Chosayerekezeka

Kugwiritsa Ntchito Maselo a NK: Kupititsa patsogolo Chithandizo cha Khansa Kupitirira Malire

0102030405

Chidule Chathunthu cha Chithandizo Choopsa cha Khansa ya M'magazi

CAR-T Therapy, mwachidule Chimeric Antigen Receptor T-Cell Immunotherapy, ndi njira yapamwamba yochiritsira majini yomwe imaphatikizapo kusintha majini a T cells a wodwala kuti awononge maselo a khansa. Mosiyana ndi mankhwala achikhalidwe, CAR-T therapy imapangidwa kwa wodwala aliyense ndipo imafuna kusonkhanitsa maselo a T kuchokera m'magazi a wodwalayo asanawabwezeretse m'thupi pambuyo pa kusintha majini.

Lumikizanani nafe

Zizindikiro za CAR-T

● B-cell acute lymphoblastic leukemia

●Myeloma yambiri

●Khansa ya m'magazi yosatha

●Non-Hodgkin lymphoma

●Kufalitsa lymphoma yaikulu ya B-cell

●SLE (Systemic Lupus Erythematosus)

●Myasthenia gravis

●Matenda ena a autoimmune

Kuchita bwino kwambiri kwachipatala cha CAR-T

Zizindikiro za CD19+20CAR-T: Odwala omwe ali ndi B-cell non Hodgkin's lymphoma

Mtengo wa CR wa mwezi umodzi	Mtengo wa PR wa mwezi umodzi	Mtengo wa OR wa mwezi umodzi	CRS≥3	CRES≥3
71.95% (59/82)	25.6 (21/82)	97.55（80/82）	12.19% (10/82)	0

Zizindikiro za CD19+22CAR-T: Chithandizo cha odwala omwe ali ndi vuto la khansa ya m'magazi ya B-lymphocytic omwe abwereranso ku CD19 komanso omwe ali ndi vuto la kuchepa kwa magazi m'thupi

Mtengo wa CR wa mwezi umodzi	Mtengo wa PR wa mwezi umodzi	Mtengo wa OR wa mwezi umodzi	CRS≥3	CRES≥3
92.1% (35/38)	7.9% (3/38)	100% (38/38)	15.79% (6/38)	0

Zizindikiro za BCMACAR-T: Chithandizo cha myeloma yambiri yobwereranso komanso yokana

Mtengo wa CR wa mwezi umodzi	Mtengo wa PR wa mwezi umodzi	Mtengo wa OR wa mwezi umodzi	CRS≥3	CRES≥3
72.41% (21/29)	27.59% (8/29)	100% (29/29)	6.9% (2/29)	0

CHIDULE CHA CHITHANDIZO CHA CAR-T (2)tch

Ubwino Wathu

● Chithandizo Choyenera Kwa Munthu AliyenseChithandizo chilichonse cha CAR-T chimapangidwa kuti chigwirizane ndi wodwalayo, kuonetsetsa kuti chithandizocho chili ndi zotsatira zabwino komanso zolondola.

● Zosankha Zosiyanasiyana Zolinga: Ndi ma antigen osiyanasiyana, kuphatikizapo CD7, CD19, CD20, CD22, ndi BCMA, zinthu zathu za CAR-T zimapereka mwayi wosiyanasiyana pochiza khansa zosiyanasiyana za m'magazi ndi matenda odziteteza ku matenda a autoimmune.

● Kupambana Kwachipatala KotsimikizikaMankhwala athu a CAR-T asonyeza kuti ndi othandiza kwambiri pa milandu yambiri yachipatala, ndipo ali ndi kuchuluka kwa kuchira kwabwino komanso chitetezo, zomwe zalimbitsa udindo wathu monga mtsogoleri pa chithandizo cha chitetezo chamthupi.

● Kugwiritsa Ntchito Mtengo Kwambiri: Timapereka chithandizo chabwino kwambiri pamitengo yotsika mtengo poyerekeza ndi zinthu zina za CAR-T zomwe zili pamsika.

● Ukadaulo Wamakono: Pogwiritsa ntchito kupita patsogolo kwaposachedwa mu uinjiniya wa majini, njira zathu zochiritsira za CAR-T zikuwonetsa tsogolo la chithandizo cha khansa ndi matenda odziteteza ku matenda.

● Chithandizo cha Akatswiri pa ZachipatalaGulu lathu lodziwa bwino ntchito la madokotala ndi ofufuza limapereka chithandizo chokwanira kuyambira pa upangiri woyamba kudzera mu kupereka chithandizo ndi kutsatira.

Maselo a CAR-T tsopano akudziwika bwino chifukwa cha kugwira ntchito kwawo bwino kwa odwala omwe sanalandire chithandizo chachikhalidwe monga chemotherapy kapena kuikidwa kwa mafupa. Madokotala padziko lonse lapansi akuvomereza kuthekera kwakukulu kwa chithandizo cha CAR-T pakusintha zotsatira za odwala.

Maphunziro ndi milandu yokhudzana ndi chithandizo cha CAR-T

1. Chithandizo cha CAR-T cha Systemic Lupus Erythematosus: Kugwira Ntchito Kodabwitsa Pankhani ya Ana

Nkhani yodziwika bwino ku Chipatala cha Erlangen University inasonyeza kuti chithandizo cha maselo a CAR-T chagwira ntchito bwino pochiza mtsikana wazaka 15 yemwe ali ndi matenda a systemic lupus erythematosus (SLE). Pambuyo pa chithandizo cholephera, Uresa adalandira chithandizo chatsopanochi mu June 2023. Patatha milungu itatu atatha kulandira chithandizo, zizindikiro zake zinali zitasintha kwambiri, zomwe zinapangitsa kuti impso zibwererenso kugwira ntchito bwino. Kupambana kumeneku ndi koyamba kugwiritsa ntchito chithandizo cha CAR-T pa matenda a autoimmune a ana, kusonyeza kuti chingathandize kuthetsa vutoli kwa nthawi yayitali komanso kusintha zotsatira za odwala. Kafukufuku wina akuchitika kuti afufuze momwe amagwiritsidwira ntchito m'mikhalidwe yofanana.

https://www.bioocus.com/news/breakthrough-in-pediatric-autoimmune-disease-car-t-cell-therapy-cures-lupus-patient/

2. Chithandizo cha CAR-T cha Multiple Myeloma: Kukhululukidwa Kwambiri Kwachitika

Bjørn Simensen, wodwala wazaka 67 wochokera ku Norway, adakumana ndi kusintha kwakukulu pankhondo yake yolimbana ndi multiple myeloma (IgG lambda, ISS-II) atalandira chithandizo cha maselo a CAR-T. Poyamba adapezeka mu 2017, adapatsidwa mankhwala angapo a chemotherapy, koma adabwereranso mu 2021. Pambuyo pa chithandizo chosagwira ntchito, adatumizidwa ku Chipatala cha Lu Daopei mu February 2022, komwe adasankhidwa kuti akalandire chithandizo cha CAR-T. Pambuyo pa chithandizo chokonzekera, maselo ake a CAR-T adalowetsedwa. Pofika tsiku la 28, mayeso otsatira adawonetsa kuti palibe maselo a plasma olakwika m'mafupa ake, zomwe zidawonetsa kupambana kwakukulu pa chithandizo chake.

https://www.bioocus.com/bj-rn-simensen-multiple-myeloma-igg-lambda-iss-ii-product/

3. Chithandizo cha CD7 CAR-T cha T-ALL ndi LBL Yobwerera M'mbuyo: Kugwira Ntchito Kodalirika ndi Zotsatirapo

Kafukufuku waposachedwapa akuwonetsa mphamvu ya chithandizo cha CD7 chimeric antigen receptor T-cell (CAR-T) pamodzi ndi njira yachiwiri yopatsirana maselo oyambira a hematopoietic hematopoietic (HSCT) kwa odwala omwe ali ndi khansa ya T-cell acute lymphoblastic leukemia (T-ALL) komanso lymphoblastic lymphoma (LBL). Kafukufukuyu adachitika ku Hebei Yanda Lu Daopei Hospital, ndipo adakhudza odwala 16 omwe adapeza chikhululukiro chathunthu cha 100% chochepa cha matenda otsalira (MRD) pambuyo pa chithandizo. Ndi chiŵerengero cha 75% cha chikhululukiro chathunthu cha zilonda zakunja kwa medullary ndi chiŵerengero cha kupulumuka kwa chaka chimodzi komanso chiŵerengero cha kupulumuka popanda leukemia cha 58.5% ndi 51.4%, motsatana, njira yatsopanoyi imapereka chiyembekezo chatsopano cha chikhululukiro cha nthawi yayitali m'makhansa amphamvu awa.

https://www.bioocus.com/news/promising-outcomes-of-cd7-car-t-therapy-combined-with-second-transplant-in-relapsed-t-all-lbl-patien/

4. Chithandizo cha CAR-T cha B-Cell Acute Lymphoblastic Leukemia: Kugwira Ntchito Kosayerekezeka

Kafukufuku waposachedwapa akuwonetsa mphamvu yapadera ya chithandizo cha chimeric antigen receptor-T cell (CAR-T) pochiza B-cell acute lymphoblastic leukemia (B-ALL). Kafukufukuyu, wochitidwa mogwirizana ndi BIOOCUS ndi Lu Daopei Hospital, wasonyeza kuti odwala ambiri adachira kwathunthu, zomwe zidayika chithandizo cha CAR-T ngati njira yotsogola yothandizira khansa ya m'magazi yoopsa iyi. Zotsatira zabwinozi zikuwonetsa kuthekera kosintha kwa chithandizo cha CAR-T mu khansa, kupereka chiyembekezo kwa odwala ndi mabanja omwe akukumana ndi B-ALL. Pamene kafukufuku akupita patsogolo, chithandizo cha CAR-T chikuyembekezeka kuchita gawo lofunikira kwambiri mtsogolo mwa chithandizo cha khansa.

https://www.bioocus.com/news/pioneering-car-t-therapy-in-b-cell-acute-lymphoblastic-leukemia-shows-unprecedented-efficacy/

Njira Yothandizira CAR-T

1. Kusonkhanitsa kwa Maselo a T:

Poyamba, madokotala amasonkhanitsa maselo a T kuchokera m'magazi a wodwalayo pogwiritsa ntchito njira yotchedwa leukapheresis. Njira imeneyi nthawi zambiri imatenga pafupifupi maola 4, pomwe cholekanitsa magazi chimachotsa maselo oyera amagazi ofunikira ndikubwezera zigawo zina zonse m'thupi la wodwalayo.

2. Kusintha ndi Kukulitsa kwa Majini:

Maselo a T osonkhanitsidwa amatumizidwa ku labotale kuti akasinthidwe majini. Mu gawo ili, maselo a T amapangidwa kuti azitha kuwononga maselo a khansa. Izi zimatenga pafupifupi milungu iwiri kapena itatu. Panthawiyi, maselo a T amayatsidwa ndikukulitsidwa mu labotale kuti atsimikizire kuti amagwira ntchito bwino polimbana ndi khansa.

3. Kulowetsedwa kwa Maselo:

Maselo a T opangidwa akakonzeka, amabwezeretsedwanso m'thupi la wodwalayo kudzera mu intravenous infusion. Gawoli limalola maselo osinthika a chitetezo chamthupi kuzindikira ndi kupha maselo a khansa moyenera.

Odwala angakumane ndi zotsatirapo zoyipa panthawi ya chithandizo, zomwe zimafala kwambiri ndi cytokine release syndrome (CRS), zomwe zimachitika chifukwa cha chitetezo chamthupi chomwe chimachepa panthawi ya kuwonongeka kwa maselo a khansa. Ngakhale kuti CRS ikhoza kukhala yoopsa, kupita patsogolo kwa chithandizo chamankhwala kwachepetsa kwambiri zoopsa zake.

Nthawi yonse ya chithandizo, kuyambira kusonkhanitsa maselo mpaka kulowetsedwa m'thupi, nthawi zambiri imakhala milungu 4-6, ngakhale kuti nthawi yeniyeniyo imadalira momwe wodwalayo alili.

Thandizo Lathunthu kwa Odwala Padziko Lonse Omwe Akupita ku BIOOCUS kukalandira Chithandizo cha CAR-T

Ku BIOOCUS, tadzipereka kupereka chisamaliro chapadera komanso chithandizo kwa odwala ochokera kumayiko ena omwe akufuna chithandizo cha CAR-T. Ntchito zathu zonse zimakhudza gawo lililonse la ulendo, kuyambira kukonzekera ulendo mpaka chisamaliro chomaliza cha chithandizo.

1. Kukonzekera Ulendo Usanayambe

Odwala asanapite ku BIOOCUS, adzayesedwa mwatsatanetsatane kuchipatala chawo chapafupi. Izi zikuphatikizapo kuwunikanso bwino mbiri yachipatala, kuyezetsa thupi, ndi mayeso oyenera monga magazi, maphunziro ojambula zithunzi, ndi kuyezetsa mtundu wa khansa yomwe ikuchiritsidwa (monga khansa ya m'magazi, khansa ya m'magazi, kapena khansa ina ya m'magazi). Timaonetsetsa kuti zolemba zonse zachipatala, kuphatikizapo chithandizo cham'mbuyomu, zotsatira za mayeso, ndi chitsimikizo cha matenda, zatumizidwa ku gulu lathu kuti liwunikenso ndikukonzekera.

2. Kuyenda ndi Kugonekedwa m'chipatala

Timathandiza pazochitika zonse zoyendera, kuphatikizapo kukonza malo ogona ndi kusungitsa malo ogona odwala ku BIOOCUS International Medical Center. Odwala akafika, amatsogoleredwa ndi njira yolandirira odwala, zomwe zimathandiza kuti azitha kupita ku malo ochizira odwala mosavuta.

3. Njira Yothandizira

Odwala akalowa m'chipatala, adzayesedwa koyamba, kuphatikizapo kuwunika kuti atsimikizire kuti ali oyenerera kulandira chithandizo cha CAR-T. Izi zidzaphatikizapo kuwunikanso momwe wodwalayo alili ndi khansa komanso thanzi lake lonse, komanso kusonkhanitsa magazi kuti achotsedwe maselo a T. Maselo a T omwe asonkhanitsidwa amatumizidwa ku labu yathu yovomerezeka ndi GMP kuti asinthe majini. Njirayi ingatenge pafupifupi milungu iwiri kapena itatu.

4. Kulowetsedwa kwa Maselo ndi Chisamaliro Pambuyo pa Chithandizo

Maselo a CAR-T osinthidwa akakonzeka, odwala adzabwerera kuchipatala chathu kuti akalandire chithandizo cha infusion. Ichi ndi chithandizo cha kamodzi kokha komwe maselo a T opangidwa amaperekedwa kudzera m'mitsempha. Pambuyo pa infusion, odwala adzakhalabe pansi pa kuyang'aniridwa kwa masiku angapo kuti aone zotsatirapo zake, monga cytokine release syndrome, yomwe ndi njira yomwe ingachitike chifukwa cha chithandizocho. Gulu lathu lachipatala limapereka chithandizo ndi kuyang'anira mosalekeza panthawi yovutayi.

Pambuyo potuluka m'chipatala, BIOOCUS imakonza maulendo obwerezabwereza, kuphatikizapo mayeso a labotale ndi maphunziro ojambula zithunzi, kuti ayang'ane momwe chithandizocho chikugwirira ntchito komanso kutsatira momwe wodwalayo akuchira. Odwala adzayang'aniridwa mosamala kuti awone ngati pali zotsatirapo zilizonse zomwe zachitika mochedwa chifukwa cha chithandizocho, ndipo gulu lathu lidzakhalabe lolumikizana kuti lipereke malangizo ndi chithandizo nthawi zonse.

Ku BIOOCUS, timaika patsogolo thanzi, chitetezo, ndi chitonthozo cha odwala athu apadziko lonse lapansi. Cholinga chathu ndikupereka chisamaliro chokwanira ndikuwonetsetsa kuti chithandizo cha CAR-T chikuyenda bwino komanso mopanda mavuto.

Kuti mudziwe zambiri zokhudza mautumiki athu ndi momwe tingakuthandizireni ndi chithandizo chanu, chonde titumizireni mwachindunji.

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