Chithandizo Chatsopano cha Majini Chimapereka Chiyembekezo Chatsopano kwa Odwala Matenda a Sickle Cell ndi Thalassemia

Chithandizo Chatsopano cha Majini Chimapereka Chiyembekezo Chatsopano kwa Odwala Matenda a Sickle Cell ndi Thalassemia

Mu chitukuko chatsopano cha odwala omwe ali ndi matenda a sickle cell (SCD) ndi thalassemia, njira yatsopano yochiritsira majini ikuwonetsa kupambana kwakukulu. Chithandizochi, chomwe chimagwiritsa ntchito ukadaulo wapamwamba wosintha majini wa CRISPR/Cas9, chawonetsa kuchuluka kwa machiritso 100% m'mayesero azachipatala, zomwe zapereka chiyembekezo chatsopano kwa iwo omwe akulimbana ndi matenda oopsa a magazi.

Chithandizochi, chomwe chinapangidwa ndi nsanja ya ModiHSC®, chimayang'ana mizu ya majini ya SCD ndi thalassemia. Mwa kusintha molondola BCL11A enhancer mu maselo a autologous hematopoietic stem ndi progenitor, chithandizochi chimalola thupi kupanga milingo yambiri ya fetal hemoglobin (HbF). Milingo yokwera ya HbF yawonetsedwa kuti ikulimbana ndi zotsatira zoyipa za sickle hemoglobin (HbS) ndikuchepetsa zizindikiro za SCD ndi thalassemia, kuphatikizapo kupewa mavuto a vaso-occlusive komanso kuchepetsa kuchepa kwa magazi m'thupi.

BIOOCUS, gulu lotsogola pankhani ya chithandizo cha majini, mogwirizana ndi Lu Daopei Hospital, lathandiza kwambiri popereka chithandizo chatsopanochi kwa odwala. 

Kupambana kwa chithandizochi sikunayerekezeredwe ndi ena, ndipo odwala 15 omwe athandizidwa mpaka pano, onse akupeza bwino komanso moyo wawo ukuyenda bwino. Kuchuluka kwa machiritso awa 100% ndi gawo lofunika kwambiri polimbana ndi SCD ndi thalassemia.

Mankhwalawa adziwika padziko lonse lapansi, ndipo akatswiri padziko lonse lapansi akuyamikira kuti ndi njira yopambana pochiza matenda a magazi m'majini. Amadziwika bwino osati chifukwa cha mphamvu zake zokha komanso chifukwa cha mtengo wake wotsika. Mosiyana ndi njira zina zochiritsira majini, zomwe zingakhale zodula kwambiri, chithandizochi chimapereka chitsanzo chamitengo chosavuta kupeza, zomwe zimapangitsa kuti chikhale njira yabwino kwa odwala ambiri.

Pa mlandu wina wovuta, wodwala wazaka 12 yemwe anali ndi vuto la vaso-occlusive crisis komanso kuchepa kwa magazi m'thupi (hemolytic anemia) adasiya zizindikiro zonse atalandira chithandizo cha majini. Mlanduwu, pakati pa ena, ukuwonetsa kuthekera kosintha kwa chithandizo cha odwala a SCD ndi thalassemia padziko lonse lapansi.

Pamene BIOOCUS ikupitiliza kukulitsa kupezeka kwa chithandizochi, kuphatikizapo mayeso azachipatala omwe akubwera ku China, tsogolo likuwoneka labwino kwa iwo omwe akhudzidwa ndi matenda ovuta awa. Mothandizidwa ndi Chipatala cha Lu Daopei, chithandizochi chikukonzekera kusintha muyezo wa chisamaliro cha SCD ndi thalassemia, zomwe zikupereka mwayi watsopano kwa odwala ambiri.

Ngati inu kapena wokondedwa wanu mukudwala matenda a sickle cell kapena thalassemia ndipo mukufuna kupeza chithandizo chatsopanochi, tikukupemphani kuti mulumikizane nafe. Gulu lathu lili okonzeka kukupatsani chithandizo ndi chidziwitso chomwe mukufuna kuti mupange zisankho zolondola zokhudza ulendo wanu wazachipatala.

Chithandizo Chokwanira kwa Odwala Padziko Lonse Omwe Akupita ku China Kukalandira Chithandizo cha Hemo-cell

Ku BIOOCUS, tadzipereka kupereka chisamaliro chapadera komanso chithandizo kwa odwala ochokera kumayiko ena omwe ali ndi matenda a thalassemia kapena sickle cell omwe akufuna chithandizo cha Hemo-cell ku China. Ntchito zathu zonse zimaphatikizapo gawo lililonse la ulendo, kuyambira kukonzekera ulendo mpaka chisamaliro chomaliza.

1. Kukonzekera Ulendo Usanayambe

Odwala asanapite kukaonana ndi dokotala, adzayesedwa bwino m'zipatala zawo zapafupi. Izi zikuphatikizapo kuwunika mbiri yonse yachipatala, kuyang'anira zizindikiro zofunika pa moyo wawo, kuyezetsa magazi, ndi kuyezetsa matenda a thalassemia kapena sickle cell. Timaonetsetsa kuti zikalata zonse zachipatala, kuphatikizapo zolemba za magazi ndi zitsimikizo za matenda, zalembedwa bwino ndikutumizidwa ku chipatala chathu kuti ziwunikidwe.

2. Ulendo ndi Kugonekedwa m'chipatala

Timathandizira njira yonse yoyendera, kuphatikizapo kukonza malo ogona odwala m'zipatala zosankhidwa. Odwala amatsogoleredwa ndi njira yolandirira odwala akafika, zomwe zimathandiza kuti asinthe mosavuta kupita ku chithandizo.

3. Njira Yothandizira

Pambuyo polowa m'chipatala, odwala adzayesedwa kangapo. Ngati apezeka kuti ndi oyenerera, kusonkhanitsa ndi kusonkhanitsa maselo oyambira a magazi kudzayamba. Maselo amenewa amatumizidwa ku malo athu a GMP kuti akayang'anire bwino komanso kupanga, pomwe odwala amatha kubwerera kudziko lawo kukayembekezera malangizo ena.

4. Kusamaliridwa ndi Kusamutsidwa kwa Odwala ndi Kutsatira

Maselo oyambira okonzedwa akavomerezedwa, odwala adzabwerera kuti akaikidwe m'malo enaake. Gulu lathu ladzipereka kupereka chithandizo chopitilira nthawi yonse yomwe wodwalayo ali m'chipatala, kuonetsetsa kuti wodwala aliyense akulandira chithandizo chapadera. Tikatuluka m'chipatala, timakonza zoyezetsa nthawi zonse kuti tiwone momwe akuchira komanso momwe alili bwino.

Pa BIOOCUS, timaika patsogolo thanzi ndi chitonthozo cha odwala athu apadziko lonse lapansi, timayesetsa kupereka chithandizo chothandiza komanso chokwanira. Kuti mudziwe zambiri zokhudza ntchito zathu, chonde titumizireni uthenga.