Chithandizo cha CAR-T cha Khansa ya M'mimba

Claudin18.2 (CLDN18.2) ndi puloteni yolumikizana yomwe imapangidwa mwachindunji mu epithelium ya m'mimba ndipo imafalikira kwambiri pamwamba pa maselo a khansa ya m'mimba. CT041 (code development code CG4006) ndi chinthu cha CAR-T chopangidwa ndi autologous chomwe chimayang'ana CLDN18.2. Deta ya Gawo Loyamba ikuwonetsa kuti pali ntchito yabwino yolimbana ndi chotupa mwa odwala khansa ya m'mimba omwe ali ndi CLDN18.2 omwe adalandira chithandizo chambiri.

Kuchuluka kwa HER2 kumawonekeranso mwa odwala khansa ya m'mimba. Mankhwala a CAR-T omwe amagwiritsidwa ntchito ndi HER2 awonetsa kuthekera kothana ndi chotupa m'maphunziro asanayambe kuchipatala komanso koyambirira. TAC01-HER2 ya Triumvira Immunologics pakadali pano ili mu mayeso azachipatala a Gawo Lachiwiri.

• Kulunjika Mwachindunji Kwambiri: Mwa kutsogolera maselo a CAR-T motsutsana ndi CLDN18.2 kapena HER2, maselo a khansa ya m'mimba amatha kuzindikirika bwino ndikuchotsedwa, kuchepetsa zotsatira zake zomwe sizili ndi chotupa.

• Kugonjetsa Kukana Chithandizo cha Mizere YambiriMu mayeso a CT041, gulu la khansa ya m'mimba linapeza chiŵerengero choyankha bwino (ORR) cha 57.1%, chiŵerengero chowongolera matenda (DCR) cha 75.0%, ndi kupulumuka kwathunthu kwa miyezi 6 (OS) kwa 81.2% mwa odwala omwe adalephera njira zingapo zamankhwala am'mbuyomu.

• Mayankho OkhazikikaChithandizo cha CLDN18.2-CAR-T chinapereka chiŵerengero cha kuyankha kwa miyezi 6 cha 44.8%, zomwe zikusonyeza kuthekera kwa phindu lachipatala kwa nthawi yayitali.

• Chithandizo Chopangidwa Mwamakonda AnuKugwiritsa ntchito maselo a T a wodwalayo kumachepetsa chiopsezo chokana mankhwala ndipo kumawonjezera chitetezo ndi mphamvu.

• Kusonkhanitsa Maselo a T a Magazi a M'mphepete mwa Magazi
  Maselo a T amachotsedwa m'magazi a wodwalayo kudzera mu leukapheresis.

• Uinjiniya wa Majini
  Mu labotale yogwirizana ndi GMP, maselo a T amasinthidwa kuti awonetse CAR yolunjika ku CLDN18.2 kapena HER2, kenako amakulitsidwa ex vivo.

• Kukonza Kuchepetsa Kuchuluka kwa Ma Lymphoma
  Mankhwala okonzekera a cyclophosphamide ndi fludarabine amaperekedwa kuti achepetse ma lymphocyte amkati ndikupanga malo abwino oti maselo a CAR-T afalikire.

• Kulowetsedwa kwa Maselo a CAR-T
  Maselo a CAR-T opangidwa mwaluso amabwezeretsedwanso mwa wodwalayo kudzera m'mitsempha.

• Kuyang'anira ndi Kuyang'anira
  Pambuyo polandira mankhwala, odwala amawunikidwa mosamala kuti awone ngati ali ndi vuto la cytokine release syndrome (CRS) komanso kuti ali ndi vuto la neurotoxicity, ndipo amathandizidwa nthawi yake ngati pakufunika.

• Kusanthula Kwakanthawi kwa Gawo I la CT041 (CLDN18.2-CAR-T)
  Pakati pa odwala 37 omwe adalandira chithandizo chamankhwala mwachangu, gulu laling'ono la khansa ya m'mimba linapeza ORR 57.1%, DCR 75.0%; 94.6% adakumana ndi CRS ya Giredi 1-2 yokha, popanda CRS ya Giredi 3 kapena kupitirira apo kapena poizoni wa mitsempha; nthawi ya miyezi 6 ya yankho inali 44.8%.

• Zotsatira Zomaliza za Gawo Loyamba (zomwe zimayang'ananso CLDN18.2)
  Mwa odwala 98 omwe anali ndi khansa ya m'mimba ya CLDN18.2, ORR inali 38.8%, DCR 91.8%; kupulumuka kwapakati kosapitirira muyeso (mPFS) kunali miyezi 4.4 (95% CI 3.7–6.6), kupulumuka kwapakati (mOS) kunali miyezi 8.8 (95% CI 7.1–10.2); 96.9% adakumana ndi CRS ya Giredi 1–2 yokha, popanda CRS ya Giredi 3+ ​​kapena imfa zina zokhudzana nazo.

• Zambiri Zoyambirira Zachipatala za HER2-CAR-T
  Kafukufuku woyamba wa Gawo Loyamba mwa anthu adawonetsa chitetezo chodalirika; mayeso olembetsa a Gawo Lachiwiri akupitilira.

• Nsanja Yotsogola Yaukadaulo
  BIOOCUS imagwira ntchito yopanga maselo a GMP padziko lonse lapansi, kuonetsetsa kuti maselo a CAR-T apangidwa bwino komanso nthawi zonse.

• Gulu la Akatswiri Osiyanasiyana
  Gulu lathu lili ndi akatswiri odziwa bwino ntchito za chitetezo chamthupi, khansa, ndi chithandizo cha maselo, omwe amapereka chithandizo chokwanira kwa munthu aliyense.

• Zochitika Zachipatala Padziko Lonse
  Tathandiza odwala ochokera padziko lonse lapansi, tikusonkhanitsa zambiri zokhudza chitetezo ndi momwe mankhwalawa amagwirira ntchito.

• Utumiki Wathunthu Wochokera Kumapeto Kupita Kumapeto
  Kuyambira pakupanga njira zochiritsira ndi kulumikizana kwa chithandizo chakunja mpaka kutsatira kwa nthawi yayitali pambuyo pa kumwa mankhwala, BIOOCUS imapereka chithandizo cha nthawi imodzi.