Yankho Lodabwitsa mu Refractory Multiple Myeloma Pambuyo pa Chithandizo cha Maselo a CAR-T

Mbiri ya OdwalaBambo Mohamed H., mwamuna wazaka 70 wochokera ku Egypt

Kuzindikira KoyambaMatenda a myeloma ambiri omwe ali ndi mafupa ambiri. PET/CT isanaperekedwe chithandizo (Julayi 2024) inawonetsa zilonda zazikulu za mafupa zomwe zimadutsa mu msana ndi m'chiuno, ndi zilonda zambiri zowononga komanso SUV yokwanira 17.9, zomwe zikusonyeza kuti matendawa amagwira ntchito kwambiri.

ChithandizoAtapita patsogolo ndi mankhwala ochiritsira a chemotherapy, a Mohamed adafunafuna njira zina zapamwamba ndipo adasankha Bioocus kuti agwiritsidwe ntchito pochiza matenda a CAR-T cell immunotherapy.

Zotsatira Zotsatira (Seputembala 2024 - miyezi iwiri yokha pambuyo pa chithandizo)Kubwerezabwereza kwa PET/CT kwa thupi lonse kwawululidwa:

• Kuchepa kwakukulu kwa ntchito ya kagayidwe kachakudya m'malo ambiri omwe anali ndi vuto la kagayidwe kachakudya
• Zilonda zambiri zatha kwathunthu (palibe kutengedwa kwachilendo kwa FDG)
• SUV yapamwamba kwambiri yatsika kuchoka pa 17.9 kufika pa 5.16
• Kungotenga mafuta pang'ono a m'mafupa kunatsala, mogwirizana ndi kusintha komwe kumachitika pambuyo pa chithandizo.
• Palibe foci yatsopano ya hypermetabolic m'mafupa kapena minofu yofewa

Bambo Mohamed anayamba kusadziwonetsa matenda atangolandira mankhwalawo. Akuti mphamvu zawo zinabwerera, mafupa sanamve kupweteka, komanso anabwerera ku moyo wawo watsiku ndi tsiku - zomwe akufotokoza kuti ndi "mwayi wachiwiri."

"Ululu usanali paliponse, ndipo ndimaganiza kuti uwu ndiye mapeto. Pambuyo pa chithandizo cha CAR-T ku Bioocus, ndikumva ngati munthu watsopano. Kujambula kwaposachedwa kukuwonetsa kuti khansa yatsala pang'ono kutha. Ndikuyamikira kwambiri." — Bambo Mohamed H.

Nkhaniyi ikuwonetsa kuthekera kwamphamvu kwa chithandizo cha CAR-T pakukwaniritsa mayankho mwachangu komanso mozama, ngakhale kwa odwala okalamba omwe ali ndi matenda a multiple myeloma omwe adachiritsidwa kale.