Bjørn Simensen----Multiple Myeloma (IgG lambda) ISS-II

Zikomo! Wodwala wochokera ku Norway, Bjørn Simensen, yemwe wachira kwa zaka ziwiri.

Bjørn Simensen, bambo wazaka 67, adafika kuchipatala mu Seputembala 2017 ndi madandaulo okhudza chifuwa ndi kupweteka pachifuwa. Pa nthawi ya opaleshoni yake, adapezeka kuti ali ndi multiple myeloma (IgG lambda) ISS-II. Wodwalayo adalandira ma cycle anayi a bortezomib, lenalidomide ndi dexamethasone chemotherapy. Pambuyo pa ma cycle anayi, protein yake ya M inali yochepera 1g/l. Wodwalayo adachotsedwa ku lenalidomide (masabata 10mg qdx3 pamwezi m) zomwe adapitiliza nazo kwa zaka ziwiri zotsatira. Anakhalabe wopanda matenda mpaka chilimwe cha 2021 pomwe panthawi yoyezetsa adapezeka kuti anali ndi protein ya M yambiri (5g/l). Lenalidomide adayimitsidwa ndipo adayamba kumwa carfilzomib ndi daratumumab chemotherapy kuyambira Okutobala mpaka Disembala 2021. Komabe, chemotherapy sinagwire ntchito ndipo BM MRD pambuyo pa chemo inali ndi kachilombo.

Bambo Bjørn Simensen adawonekera koyamba ku chipatala chathu cha CGT pa 14 February 2022. BM MRD yake idawonetsa maselo osazolowereka a 0.25 peresenti. IEF idawonetsa kuti IgG ndi mapuloteni a M anali 3 g/l. PET-CT Scan idawonetsa kuchuluka kwa kuyamwa kwa ma testis makamaka oyenera omwe adakulitsidwanso powafufuza. Biopsy ya ma testicular idachitika yomwe idawonetsa maselo oopsa a plasma. Wodwalayo adasankhidwa kuti alandire chithandizo cha CART cell. Kukonza kunachitika ndi fludarabine ndi cyclophosphamide kwa masiku atatu. Maselo a CAR-T adalowetsedwa pa tsiku la 0 (4/3/2222). Mlingo woperekedwa unali 0.5X10^6 /kg. Pambuyo polowetsedwa, wodwalayo anali ndi malungo a neutropenia omwe adawongoleredwa ndi maantibayotiki a iv. Kutupa kwa ma testicular kumanja kunachepa pang'onopang'ono kufika pakukula kwabwinobwino. Pa tsiku la 28, mayeso a BM analibe maselo a plasma. Wodwalayo adatulutsidwa ku Lu Daopei ndi kutsatiridwa pafupipafupi ku hematology centre mumzinda wake.