Bjørn Simensen----Multiple Myeloma (IgG lambda) ISS-II

Hoʻomaikaʻi! He mea maʻi mai Norewai mai, ʻo Bjørn Simensen, me ʻelua mau makahiki o ke kala ʻana.

Ua hōʻea ʻo Bjørn Simensen, he kanaka 67 makahiki, i ka haukapila i Kepakemapa 2017 me nā hoʻopiʻi o ke kuni a me ka ʻeha o ka umauma. I kāna hana ʻana, ua ʻike ʻia he multiple myeloma (IgG lambda) ISS-II kona. Ua loaʻa i ka mea maʻi he 4 mau pōʻaiapuni o ka bortezomib, lenalidomide a me dexamethasone chemotherapy. Ma hope o 4 mau pōʻaiapuni, ʻoi aku ka liʻiliʻi o kāna protein M ma mua o 1g/l. A laila ua hoʻopau ʻia ka mea maʻi mai ka mālama ʻana i ka lenalidomide (10mg qdx3 mau pule i kēlā me kēia mahina m) āna i hoʻomau ai no nā makahiki 2 e hiki mai ana. Ua noho ʻo ia me ka maʻi ʻole a hiki i ke kauwela o 2021 i ka wā o ka loiloi hoʻomaha ua ʻike ʻia ua hoʻonui ʻia ka protein M (5g/l). Ua hoʻōki ʻia ʻo Lenalidomide a ua hoʻomaka ʻia ʻo ia ma ka carfilzomib a me daratumumab chemotherapy mai ʻOkakopa a Dekemaba 2021. Eia naʻe, ʻaʻole i kūpono ka chemotherapy a ua maikaʻi ka post-chemo BM MRD.

Ua ʻike mua ʻia ʻo Mr. Bjørn Simensen ma kā mākou kikowaena CGT ma ka lā 14 o Pepeluali 2022. Ua hōʻike kāna BM MRD i 0.25 pakeneka o nā cell plasma maʻamau ʻole. Ua hōʻike ʻo IEF i ka protein IgG a me M he 3 g/l. Ua hōʻike ʻo PET-CT Scan i ka hoʻonui ʻia ʻana o ka lawe ʻana i loko o ka testis, ʻoiai ka mea ʻākau i hoʻonui ʻia i ka nānā ʻana. Ua hana ʻia kahi biopsy testicular i hōʻike i nā cell plasma malignant. Ua koho ʻia ka mea maʻi no ka lāʻau lapaʻau cell CART. Ua hana ʻia ka hoʻomaʻamaʻa mua ʻana me ka fludarabine a me ka cyclophosphamide no 3 mau lā. Ua hoʻokomo ʻia nā cell CAR-T i ka lā 0 (4/3/2222). ʻO ka nui i hāʻawi ʻia he 0.5X10^6 /kg. Ma hope o ka hoʻokomo ʻana, ua loaʻa i ka mea maʻi ke kuni neutropenia i kāohi ʻia me nā antibiotics iv. Ua emi mālie ka pehu ʻana o ka testicular ʻākau i ka nui maʻamau. I ka lā 28, ua maikaʻi ʻole ka nānā ʻana o BM no nā cell plasma. Ua hoʻokuʻu ʻia ka mea maʻi mai Lu Daopei me ka nānā mau ʻana ma ke kikowaena hematology ma kona kūlanakauhale.