Ke lanakila nei i ka Lymphoma B-Cell Nui Diffuse me ka Bioocus Dual CAR-T Therapy

Ka Moʻolelo o ka Mea Maʻi

ʻO Rodney, he kanaka kūpaʻa mai ka ʻāina ʻē, ua ʻike ʻia ʻo ia me ka Diffuse Large B-Cell Lymphoma (DLBCL), kahi ʻano huhū o ka lymphoma non-Hodgkin. I kona mau makahiki 68, ua ʻimi ʻo ia i nā koho lapaʻau holomua ma hope o ka lawa ʻole o nā lāʻau lapaʻau maʻamau. Ua kuhikuhi ʻia i kā mākou hale hana hoa ma ka Halemai Kanesa ʻo Tianjin, ua kākau inoa ʻo Rodney i ka protocol therapy CAR-T pālua a Bioocus ma lalo o ka helu lapaʻau P1549. Hoʻopili kēia lāʻau lapaʻau i nā antigens CD19 a me CD20 ma nā cell cancer, e hāʻawi ana i kahi hoʻouka kaua pālua e hoʻonui i ka pono a hoʻemi i ka pilikia o ka hoʻi hou ʻana.

Ka Huakaʻi Lapaʻau

Ua hoʻomaka ka lāʻau lapaʻau ʻana o Rodney i Kepakemapa 2025 me ka hoʻokomo ʻia ʻana o nā pūnaewele CAR-T autologous i hana ʻia e hōʻike i nā mea loaʻa antigen chimeric no CD19 a me CD20. ʻO ke kaʻina hana e pili ana i ka hōʻiliʻili ʻana i kāna hāpana koko peripheral (PB), hana ʻana iā ia e hana i nā pūnaewele CAR-T pilikino, a me ka hoʻokomo ʻana i kahi mahele i kūpono i kāna mau pono. Ma hope o ka hoʻokomo ʻana, ua nānā pono ʻia kona holomua ma o nā hoʻāʻo koko serial i nā lā hahai koʻikoʻi: Lā 4 (D4), Lā 7 (D7), a me Lā 10 (D10).

• D4 (Kepakemapa 12, 2025):Ua hōʻike ka ʻike mua ʻana i kahi liʻiliʻi o nā pūnaewele CAR-T, me nā pūnaewele CD19+ CAR-T ma 0.50% o nā pūnaewele CD3+ T (waiwai paʻa: 6.04 × 10^6/L) a me nā pūnaewele CD20+ CAR-T ma 0.41% (waiwai paʻa: 4.96 × 10^6/L). Ua hōʻike kēia pae mua i ka holomua o ka engraftment.
• D7 (Kepakemapa 15, 2025):Ua wikiwiki ka hoʻonui ʻana, me ka piʻi ʻana o nā pūnaewele CD19+ CAR-T i 1.68% (waiwai paʻa: 1.40 × 10^7/L) a me nā pūnaewele CD20+ CAR-T i 1.63% (waiwai paʻa: 1.36 × 10^7/L), e hōʻike ana i ka hoʻonui ikaika.
• D10 (Kepakemapa 18, 2025):Ua ʻike ʻia ka hoʻonui ʻana o ka piko kupaianaha, me nā pūnaewele CD19+ CAR-T e hōʻea ana i 31.43% o nā pūnaewele CD3+ T (waiwai paʻa: 3.13 × 10^8/L) a me nā pūnaewele CD20+ CAR-T ma 32.74% (waiwai paʻa: 3.26 × 10^8/L). Ua hōʻike ka loiloi subset i ka hoʻolaha kaulike ma waena o nā pūnaewele CD4+ a me CD8+ T, me ka helu holoʻokoʻa o nā pūnaewele T ma 2.9 × 10^9/L, me 34.35% o nā pūnaewele CD3+ T.

Ma loko o ka nānā ʻana, ua hōʻike ka ʻaoʻao pale o Rodney i nā loli maikaʻi, e like me ke kiʻekiʻe o nā pūnaewele T cytotoxic (CD3+CD8+ ma 69.56%), e hōʻike ana i ka hiki o ka lāʻau lapaʻau ke hoʻoneʻe i kāna ʻōnaehana pale e kūʻē i ka lymphoma.

Nā Hopena Koʻikoʻi

Ma ka D10, ʻo ka ulu nui ʻana o nā pūnaewele CAR-T—ʻoi aku ma mua o 500 mau manawa i ka piʻi ʻana o nā helu maoli mai D4—ua hōʻike i ka hana anti-tumor ikaika o ka lāʻau lapaʻau. ʻO kēia hoʻonui wikiwiki ʻana he hōʻailona ia o ka mālama ʻana iā CAR-T holomua, e pili pinepine ana me nā hoʻomaha hohonu a mau loa i nā maʻi DLBCL. Ua ʻae maikaʻi ʻo Rodney i ka lāʻau lapaʻau, me ka ʻole o nā pilikia nui i hōʻike ʻia i ka wā nānā. Hōʻike kāna hihia i ke ʻano pālua o Bioocus's CAR-T, kahi i hoʻokō ai i ka pane piha kiʻekiʻe (CR) a me nā helu pane holoʻokoʻa (ORR) ma waena o kā mākou hui maʻi honua.