ʻO Mr. C----Diffuse Large B-cell Lymphoma (DLBCL)

ʻO kēia maʻi, ʻo Mr. C, mai India mai a he 55 ona makahiki. I ka hoʻomaka ʻana o 2019, ua hōʻike ʻo ia me ka lymphadenopathy systemic mau loa a ua ʻimi ʻo ia i ke kōkua lapaʻau ma kā mākou hale. Ua hana ʻia nā loiloi nui, i alakaʻi ʻia ai ka ʻike ʻana o ka Diffuse Large B-Cell Lymphoma (DLBCL). Ma muli o ke ʻano ikaika o DLBCL, he mea nui ka hoʻomaka koke ʻana i ka lāʻau lapaʻau e hoʻoponopono pono i ke kūlana.

Ma mua o ka hoʻokō ʻana i ka lāʻau lapaʻau CAR-T, ua hele ʻo Mr. C i kekahi mau ʻike lapaʻau outpatient e pili ana i nā ʻano chemotherapy like ʻole. I ka wā mua, ua loaʻa iā ia ʻo RCHOP ma ke ʻano he lāʻau lapaʻau laina mua, a ukali ʻia e nā lāʻau lapaʻau ma hope e like me REPOCH, R2-ICE, GEMOX-BTKi, Pola-BR, GB261, TQB2916, GA 101-Cedarbenamine-Doxil, a ʻo ka hope loa, ʻo Inotuzumab. ʻOiai ua lawelawe ʻia kēia mau lāʻau lapaʻau i loko o kekahi manawa a ua hōʻike i kekahi pono, ʻaʻole lākou i hoʻokō i ka hoʻomalu ʻana i ka maʻi, e hōʻike ana i ke ʻano huhū o ka DLBCL a Mr. C.

Ma muli o ka nele o ka pane kūpono i nā lāʻau lapaʻau maʻamau a me ka holomua wikiwiki o kona kūlana, ua ʻike ʻia ʻo Mr. C he moho no ka lāʻau lapaʻau CAR-T cell. Ma hope o nā kaʻina hana hoʻomākaukau pono, ua hana ʻia ʻo Mr. C i ka lāʻau lapaʻau CAR-T cell i ka hoʻomaka ʻana o 2020. ʻO kēia ʻano lapaʻau hou e pili ana i ka hoʻololi ʻana i nā cell T ponoʻī o ka mea maʻi e kuhikuhi a hoʻouka i nā cell kanesa me ka ʻoi aku ka maikaʻi.

Iwakāluakūmāwalu mau lā ma hope o ka hoʻokomo hou ʻana o nā pūnaewele CAR-T, ua ʻike ʻia ka hoʻomaha nui ʻana o ka maʻi, e hōʻailona ana i ka holomua o ka lāʻau. Ua lawe mai kēia hopena i ka manaʻolana hou a me ka manaʻolana iā Mr. C a me kāna hui mālama ola. Hōʻike ka pane kupaianaha i ka lāʻau CAR-T i ka hiki o ka immunotherapy i ka mālama ʻana i nā maʻi hematologic koʻikoʻi e like me DLBCL.

I ka neʻe ʻana i mua, e hoʻomau ʻia ka nānā ʻana a me nā manawa hoʻopaʻa ʻana o Mr. C e nānā pono i kona kūlana. ʻO ka kaohi ʻana i ka maʻi lōʻihi a me ke kūpaʻa nā pahuhopu koʻikoʻi o kāna hoʻolālā mālama e hoʻomau nei. ʻO ka hopena holomua o ka lāʻau lapaʻau CAR-T e hōʻike ana i ke koʻikoʻi o nā ʻano hana pilikino a me nā mea hou i ka hoʻokele ʻana i nā maʻi ʻaʻai paʻakikī, e hāʻawi ana i nā manaʻolana hoʻohiki no nā poʻe maʻi e like me Mr. C.

Ma mua a me 28 mau lā ma hope