UMnu. C----Diffuse Large B-cell Lymphoma (DLBCL)

Esi sigulana, uMnu. C, sivela eIndiya kwaye sineminyaka engama-55 ubudala. Ekuqaleni kuka-2019, safumana isifo se-lymphadenopathy esingapheliyo kwaye safuna unyango kwiziko lethu. Kwenziwe uvavanyo olubanzi, nto leyo eyakhokelela ekuxilongweni kwe-Diffuse Large B-Cell Lymphoma (DLBCL). Ngenxa yobundlobongela be-DLBCL, ukuqaliswa konyango ngokukhawuleza kwakubalulekile ukuze kujongwane nale meko ngokufanelekileyo.

Ngaphambi kokuba afumane unyango lwe-CAR-T, uMnu. C wenze uthotho lwamava eklinikhi angalaliswanga esibhedlele aquka iindlela ezahlukeneyo zonyango lwe-chemotherapy. Ekuqaleni, wafumana i-RCOP njengonyango lokuqala, kwalandela unyango olulandelayo oluquka i-REPOCH, i-R2-ICE, i-GEMOX-BTKi, i-Pola-BR, i-GB261, i-TQB2916, i-GA 101-Cedarbenamine-Doxil, kwaye ekugqibeleni, i-Inotuzumab. Nangona olu nyango lwalunikwa ixesha elide kwaye lubonise ukusebenza kakuhle, aluzange luphumelele ekulawuleni izifo, nto leyo egxininisa ubundlongondlongo be-DLBCL kaMnu. C.

Ngenxa yokungabikho kwempendulo eyanelisayo kunyango oluqhelekileyo kunye nokuqhubela phambili ngokukhawuleza kwemeko yakhe, uMnu. C wachongwa njengomviwa we-CAR-T cell therapy. Emva kweenkqubo zokulungiselela ezicokisekileyo, uMnu. C waqeshwa kwi-CAR-T cell therapy ekuqaleni kuka-2020. Le ndlela yonyango intsha ibandakanya ukuguqula ii-T cells zesigulana ukuze zijolise kwaye zihlasele iiseli zomhlaza ngempumelelo.

Iintsuku ezingamashumi amabini anesibhozo emva kokufakwa kwakhona kweeseli ze-CAR-T, kwabonwa ukukhululeka okukhulu kwesifo, nto leyo eyaphawula impumelelo yonyango. Esi siphumo sazisa ithemba elitsha kunye nethemba kuMnu. C kunye neqela lakhe lezempilo. Impendulo emangalisayo kunyango lwe-CAR-T igxininisa amandla e-immunotherapy ekunyangeni izigulana ezinobungozi zegazi ezifana ne-DLBCL.

Ukuya phambili, uMnu. C uza kuqhubeka ejongwa kwaye adibane nabantu abaza kumlandela ukuze ajonge imeko yakhe ngokusondeleyo. Ulawulo lwesifo sexesha elide kunye nokuzinza ziinjongo ezibalulekileyo zesicwangciso sakhe sonyango oluqhubekayo. Isiphumo esiphumeleleyo sonyango lwe-CAR-T sigxininisa ukubaluleka kweendlela ezenzelwe wena kunye nezintsha ekulawuleni umhlaza ontsonkothileyo, zibonelela ngamathuba athembisayo kwizigulana ezinjengoMnu. C.

Ngaphambi nangeentsuku ezingama-28 emva