UMnu. C---- I-Diffuse Large B-cell Lymphoma (DLBCL)

Lesi siguli, uMnu. C, sivela eNdiya futhi sineminyaka engu-55 ubudala. Ekuqaleni kuka-2019, waba nesifo se-lymphadenopathy esiqhubekayo futhi wafuna usizo lwezokwelapha esikhungweni sethu. Kwenziwa ukuhlolwa okubanzi, okwaholela ekuxilongweni kwe-Diffuse Large B-Cell Lymphoma (DLBCL). Njengoba i-DLBCL inolaka, ukuqaliswa kokwelashwa ngokushesha kwakubalulekile ukuze kulungiswe lesi simo ngempumelelo.

Ngaphambi kokwelashwa nge-CAR-T, uMnu. C welashwa ngochungechunge lwezinhlupheko zasemtholampilo ezingalaliswa esibhedlela ezibandakanya izindlela ezahlukene zokwelashwa ngamakhemikhali. Ekuqaleni, wathola i-RCOP njengokwelashwa kokuqala, kwalandela ukwelashwa okulandelayo okuhlanganisa i-REPOCH, i-R2-ICE, i-GEMOX-BTKi, i-Pola-BR, i-GB261, i-TQB2916, i-GA 101-Cedarbenamine-Doxil, kanye ne-Inotuzumab. Nakuba lezi zindlela zokwelapha zanikezwa isikhathi eside futhi zabonisa ukusebenza kahle, zehlulekile ukufeza ukulawulwa kwezifo, okugcizelela isimo sobudlova se-DLBCL kaMnu. C.

Ngenxa yokuntuleka kwempendulo eyanelisayo ekwelashweni okuvamile kanye nokuqhubeka okusheshayo kwesimo sakhe, uMnu. C wahlonzwa njengomuntu ozongenela ukwelashwa ngamaseli e-CAR-T. Ngemva kwezinqubo zokulungiselela ngokucophelela, uMnu. C wenziwa ukwelashwa ngamaseli e-CAR-T ekuqaleni kuka-2020. Le ndlela yokwelapha entsha ihilela ukuguqula amaseli e-T esiguli ukuze ahlasele futhi ahlasele amaseli omdlavuza ngempumelelo enkulu.

Ezinsukwini ezingamashumi amabili nesishiyagalombili ngemva kokufakwa kabusha kwamaseli e-CAR-T, kwabonakala ukuphulukiswa okukhulu kwesifo, okwaphawula impumelelo yokwelashwa. Lo mphumela waletha ithemba elisha kanye nethemba kuMnu. C kanye nethimba lakhe lezokunakekelwa kwempilo. Impendulo emangalisayo ekwelashweni kwe-CAR-T iqokomisa amandla okwelashwa nge-immunotherapy ekwelapheni umdlavuza we-hematologic onamandla njenge-DLBCL.

Ukuqhubekela phambili, uMnu. C uzoqhubeka nokubhekwa kanye nokuqokwa kokulandela ukuze aqaphe isimo sakhe eduze. Ukulawulwa kwezifo zesikhathi eside kanye nokuzinza kuyimigomo ebalulekile yohlelo lwakhe lokunakekelwa oluqhubekayo. Umphumela ophumelelayo wokwelashwa kwe-CAR-T ugcizelela ukubaluleka kwezindlela ezenzelwe wena kanye nezintsha ekuphathweni komdlavuza oyinkimbinkimbi, okunikeza amathuba athembisayo ezigulini ezinjengoMnu. C.

Ngaphambi nangemva kwezinsuku ezingama-28