Ukunqoba kukaMadhavan: Ukunqoba i-Brain Glioma nge-Bioocus B7H3 CAR-T Therapy

Isizinda Sesiguli

UMadhavan watholakala enesifo se-brain glioma, isimila esibi esaziwa ngokungena kwaso kanye nokubikezela okubi. Eseneminyaka engu-58, ngemuva kokuba ukwelashwa okuvamile okuhlanganisa ukuhlinzwa kanye nokushiswa kwemisebe kuhlulekile, waphendukela ku-Bioocus ukuze athole izinketho ezithuthukisiwe. Wathunyelwa eSibhedlela saseTianjin Tumor Hospital Konggang, wabhalisa ohlelweni lwethu lwe-B7H3 CAR-T ngaphansi kwenombolo yokwelashwa P001. I-B7H3 ibonakaliswa kakhulu kumaseli e-glioma, okwenza kube yindawo efanelekile yamaseli e-T aklanywe ngoketshezi lwe-cerebrospinal (CSF) ukuhlasela isimila ngqo.

Uhambo Lokwelapha

Ukwelashwa kukaMadhavan kwakuhilela ukufaka amaseli e-CAR-T e-autologous ku-CSF, ngokuqapha ngokuhlaziywa kwe-CSF okulandelanayo kusukela osukwini 2 (D2) kuya osukwini 28 (D28).

• D2 (Agasti 8, 2025):Ukuba khona okuqinile kokuqala nge-B7H3 CAR-T ku-54.44% wamaseli e-CD3+ T.
• D4 (Agasti 11, 2025):52%, okubonisa ukuguquguquka kwasekuqaleni.
• D7 (Agasti 14, 2025):Ikhuphuke yaya ku-59.51%.
• D10 (Agasti 17, 2025):12%.
• D14 (Agasti 21, 2025):19%.
• D21 (Agasti 28, 2025):Ifinyelele esicongweni ku-89.69%, okubonisa ukwanda okumangalisayo.
• D28 (Septhemba 6, 2025):Kuzinze ku-13.58% wamaseli e-CD3+ T, kanye no-11.90% ku-CD4+ kanye no-14.28% kuma-subset e-CD8+. Sekukonke, amaseli e-CD3+ T abusa ku-95.34%, kanye ne-CD8+ ephezulu (66.74%) ekhombisa ubuthi obunamandla.

Amagrafu okwandisa abonisa ukuphikelela kwe-CAR-T okushintshashintshayo kodwa okuqinile, okubalulekile ekulawulweni kwesimila okuqhubekayo ku-CNS.

Imiphumela Evelele

Ukwanda okuphezulu kwe-D21 kuhlobene nokuncipha kwesimila ku-MRI, okuholele ekuphenduleni okuyingxenye yi-D28 kanye nokuthuthuka okuqhubekayo. Lokhu kulethwa ngaphakathi kwe-thecal kunciphisa imiphumela emibi yesistimu ngenkathi kukhulisa ukusebenza kahle ngokumelene nama-glioma, kanye nedatha yethu ekhombisa ukusinda okuthuthukisiwe okungenakho ukuqhubekela phambili. UMadhavan ubike izimpawu ezilawulekayo kanye nokungabi nabuthi obukhulu be-neurological.