I-melanoma yeso (ekuqaleni), ilandelwe yizimila zesibindi ezisakazeke kabanzi-02

Ngo-2021, uNkk. Y wavele wabona into engajwayelekile ekuboneni kweso lakhe lokunene. Ukuhlolwa okuphelele kwembula ukuthi wayene-melanoma yamehlo. Ngenhlanhla, yatholakala kusenesikhathi futhi yahlukaniswa njengesigaba 1A, kanye nethuba elingu-2% kuphela lokusabalala kwamangqamuzana. Ngemva kokwelashwa ngemisebe, wayengenawo umdlavuza okwesikhashana, yize izindleko zaziwukungaboni unomphela kweso elithintekile.

Kodwa-ke, ngeshwa, isimila sabuya ngonyaka olandelayo futhi saqala ukuthuthuka ngokushesha. Izithombe zibonise ukuthi isibindi sakhe sase sinezimila ezingaphezu kweshumi ezinobukhulu obuhlukahlukene. Ngenxa yalokho, ochwepheshe batusa ukuthi ahlanganyele ocwaningweni lwezokwelapha lwe-TIL (tumor-infiltrating lymphocyte).

Uyise nomyeni kaNkk. Y baqoqa amarekhodi akhe ezokwelapha baxhumana nodokotela kulo lonke izwe ukuze bathole isivivinyo somtholampilo esifanele, ekugcineni bathole uhlelo lwethu. Le ndlela isebenzisa amangqamuzana omzimba omzimba ukulwa nomdlavuza.

Odokotela basusa ingxenye yesimila esibindini sikaNkz Y ngokuhlinzwa, bahlukanisa amaseli e-T abulalayo kuso, futhi bawandisa abalelwa ku-10 kuya ku-150 billion, bakha ibutho lamaseli e-clone. Leli butho elikhulu lamaseli labe selifakwa emzimbeni wakhe ukuze lilethe ukuhlaselwa okunembile, okunamandla, nokuqhubekayo kumaseli omdlavuza.

Ukutshalwa kwamaseli e-TIL kwathatha cishe amasonto amathathu futhi kwadinga iseshini yokwelashwa eyodwa kuphela. NgoSepthemba 2023, uNkk. Y wenziwa isonto le-chemotherapy, i-TIL infusion, kanye ne-IL-2. Lokhu kwelashwa okunamandla kwabangela imiphumela emibi kakhulu, okuhlanganisa ubuhlungu bamalunga, ukucindezeleka kokuphefumula, izimpawu zesisu, ukuqubuka, kanye nekhanda elibuhlungu kakhulu.

Nokho, ngemva kokuba le miphumela emibi isiphelile, kwenzeka isimangaliso. Ukwelashwa kwe-TIL kwabonakala kusebenza kahle kakhulu. Phakathi nonyaka, cishe zonke izimila zikaNkk. Y zase zinyamalele noma zinciphile, kwasala eyodwa kuphela. Ngo-2024, odokotela basusa cishe ingxenye yesibindi sakhe, kuhlanganise nesimila sokugcina. Lapho evuka, watshelwa ukuthi akukho zimpawu zesifo ezisele emzimbeni wakhe.