Isifo Se-Sickle Cell kanye ne-Thalassemia

E-BIOOCUS International Treatment Center, siyaziqhenya ngokwethula I-Hemo-cell, ukwelashwa kwezakhi zofuzo okusha okunikeza ithemba elisha ezigulini ezihlushwa yi- isifo se-sickle cell (SCD) futhi i-thalassemia encike ekufakweni kwegazi (TDT)I-Hemo-cel iklanyelwe ukubhekana nembangela eyinhloko yalezi zimo, inikeza ukwelashwa okungenzeka ngokwelashwa kanye kuphela.

Kuyini i-Hemo-cell?

I-Hemo-cel iyindlela yokwelapha ethuthukisiwe esebenzisa amaseli e-hematopoietic stem kanye ne-progenitor yesiguli (ama-HSPC), aguqulwa ngofuzo ukuze akhiqize i-hemoglobin enempilo. Ngokulungisa i-gene enephutha ebangela ukuphazamiseka kwegazi, i-Hemo-cel ingathuthukisa kakhulu izimpilo zeziguli, okungenzeka iqede isidingo sokumpontshelwa igazi njalo futhi inikeze ikhambi lokuphila konke.

Isebenza Kanjani I-Hemo-cell?

Inqubo yokwelapha iqala ngokuqoqa ama-HSPC egazini lesiguli. Lawa maseli abe esethuthukiswa ngaphandle komzimba kusetshenziswa i-lentiviral vector eyethula i-gene eguquliwe ye-β-globin. Uma amaseli esekulungele, abuyiselwa esigulini, lapho aqala khona ukukhiqiza amaseli abomvu egazi anempilo akwazi ukukhiqiza i-hemoglobin esebenzayo. Le nqubo ibuyisela ibhalansi phakathi kwamaketanga e-α-globin kanye ne-β-globin egazini, inciphise ngempumelelo izimpawu ze-anemia futhi ivumele isiguli ukuthi sifinyelele ukuzimela ekumpontshelweni igazi.

Imiphumela Efakazelwe

Ukuhlolwa kwezokwelapha kwe-Hemo-cell kukhombisile impumelelo emangalisayo:

• Iziguli eziyi-100% ocwaningweni bathole impumelelo ekufakweni komnkantsha wethambo.
• Iningi leziguli laba okungaxhomekeki ekufakweni kwegazi phakathi namasonto ngemva kokwelashwa.
• Isiguli esisodwa besilokhu singampontshelwa igazi cishe isikhathi eside iminyaka emine ngaphandle kwemiphumela emibi ebalulekile.
• Ukwelashwa kusiza futhi ekunciphiseni ukugcwala kwensimbi, okuyinkinga evamile ezigulini ze-TDT ezimpontshelwa igazi njalo.

Enye Indlela Ephephile

Ngokungafani nokwelashwa kwendabuko njengokufakelwa kwamaseli e-hematopoietic stem (HSCT), okudinga ukufaniswa komnikeli futhi okuthwala izingozi ezifana nesifo se-graft-versus-host (GVHD), I-Hemo-cell isebenzisa amaseli esiguli uqobo, ukugwema lezi zinkinga. Lokhu kwenza ukwelashwa kube kuphephile futhi kufinyeleleka kalula ezigulini eziningi, ngaphandle kwesidingo sokwelashwa isikhathi eside okucindezela amasosha omzimba.

Ukwanda Kwethu Emhlabeni Wonke

Njengoba sesiphumelele kakhulu eShayina, manje sesanda ukutholakala kweHemo-cel emhlabeni jikelele. Ngokubambisana kwezokwelapha e-China I-Saudi Arabia, Thailand, Malaysia, nokuningi, sizibophezele ekwenzeni lokhu kwelashwa okusha kutholakale kalula ezigulini emhlabeni jikelele.

Ikusasa Elingenakho Ukumpontshelwa

I-Hemo-cel inikeza ikusasa elithembisayo kulabo abathintekile yi-SCD kanye ne-beta-thalassemia. Cabanga ngempilo engenakho ukumpontshelwa igazi njalo, enethuba lokwelashwa okuhlala njalo. Kwa-BIOOCUS, sizibophezele ekwenzeni lo mbono ube ngokoqobo ngezixazululo zokwelapha izakhi zofuzo ezisezingeni eliphezulu njenge-Hemo-cel.

Xhumana nathi namuhla ukuze ufunde kabanzi ngendlela i-Hemo-cell engalushintsha ngayo uhambo lwakho lokwelashwa futhi ikunikeze ikusasa eliqhakazile nelinempilo.