Chirwere cheSickle Cell & Thalassemia

KuBIOOCUS International Treatment Center, tinodada nekuzivisa nezve Hemo-cell, mushonga wezvemajini unoshamisa unopa tariro itsva kuvarwere vanotambura nechirwere ichi chirwere chemasero anorwara (SCD) uye thalassemia (TDT) inotsamira pakuwedzerwa ropaHemo-cel yakagadzirirwa kugadzirisa chikonzero chikuru chezvirwere izvi, ichipa mushonga unogona kurapwa kuburikidza nekurapwa kamwe chete.

Chii chinonzi Hemo-cell?

Hemo-cel mushonga wepamusoro unoshandisa masero eropa emurwere (HSPCs), ayo anogadziriswa majini kuti agadzire hemoglobin ine hutano. Nekugadzirisa jini risina kunaka rinokonzera dambudziko reropa, Hemo-cel inogona kuvandudza hupenyu hwevarwere zvikuru, zvichigona kubvisa kudiwa kwekuwedzerwa ropa nguva dzose uye kupa mhinduro yehupenyu hwese.

Hemo-cell inoshanda sei?

Maitiro ekurapa anotanga nekuunganidza maHSPC kubva muropa remurwere. Masero aya anozowedzerwa kunze kwemuviri achishandisa lentiviral vector iyo inoisa gene reβ-globin rakagadziriswa. Kana masero agadzirira, anodzoserwa mumurwere, kwaanotanga kugadzira masero matsvuku eropa ane hutano anokwanisa kugadzira hemoglobin inoshanda. Maitiro aya anodzoreredza kuenzana pakati pe α-globin ne β-globin cheni muropa, zvichideredza zviratidzo zve anemia uye zvichibvumira murwere kuwana rusununguko rwekuisira ropa.

Zvakawanikwa Zvakaratidzwa

Miedzo yekiriniki yeHemo-cell yakaratidza kubudirira kunoshamisa:

• 100% yevarwere Mukuedzwa uku, vakabudirira kubatanidzwa kwemapfupa emubofu.
• Varwere vazhinji vakava isingabatanidzwi neropa mukati memavhiki mushure mekurapwa.
• Mumwe murwere ave asina kuwedzerwa ropa kwenguva inenge makore mana pasina migumisiro yakakosha.
• Kurapa uku kunobatsirawo kuderedza kuwanda kwesimbi mumuviri, dambudziko rinowanzoitika muvarwere veTDT vanowedzerwa ropa nguva nenguva.

Imwe Nzira Yakachengeteka

Kusiyana nekurapa kwechinyakare kwakadai sekuiswa kwemasero eropa (HSCT), kunoda munhu anokupa rubatsiro uye kune njodzi dzakadai sechirwere chegraft-versus-host (GVHD), Hemo-cell inoshandisa masero emurwere pachakekudzivirira matambudziko aya. Izvi zvinoita kuti kurapwa zvakachengeteka uye inowanikwa nyore nyore nevarwere vakasiyana-siyana, pasina chikonzero chekurapwa kwenguva refu kwekudzivirira muviri.

Kuwedzera Kwedu Pasi Pose

Zvatakabudirira zvikuru muChina, tava kuwedzera kuwanikwa kweHemo-cel pasi rose. Nekubatana kwekiriniki mu Saudi Arabia, Thailand, Malaysia, nezvimwewo, takazvipira kuita kuti kurapwa uku kutsva kuve nyore kuvarwere pasi rese.

Remangwana Pasina Kuisirwa Mafuta

Hemo-cel inopa ramangwana rakanaka kune avo vanobatwa neSCD ne beta-thalassemia. Fungidzira hupenyu husina kuwedzerwa ropa nguva dzose, hune mukana wekurapwa zvachose. KuBIOOCUS, takazvipira kuita kuti chiono ichi chiitike kuburikidza nemhinduro dzemazuva ano dzekurapa majini seHemo-cel.

Taura nesu nhasi kuti mudzidze zvakawanda nezvekuti Hemo-cel ingashandura sei rwendo rwenyu rwekurapwa uye kupa ramangwana rakajeka uye rine hutano.