Kurapa kweTIL Kwaburitswa: Kuongorora Mamiriro Ekurapa Nekurapa Nekenza

Kurapa kweTIL kunosanganisira kubvisa malymphocyte anopinza tumor (TILs), ayo ari masero ekudzivirira emuviri anonyatsorwisa tumor mumuviri wemurwere, kubva mubundu uye kuagadzira akawanda murabhoritari. MaTIL aya anozodzorerwa mumuviri wemurwere kuti asimbise kugona kwemasoja ekudzivirira muviri kurwisa nekuuraya masero ekenza. MaTIL anoshanda nekuona zviratidzo pamasero ekenza uye kutanga mhinduro yekudzivirira muviri paari, zvichizoguma nekuparadzwa kwebundu.

Zvichibva pamigumisiro yekurapwa kwedu, kushanda kweTILs monotherapy kunosvika pa40%, zvichiita kuti ive nzira inoshanda zvikuru yekurapa bundu kunze kwekuvhiyiwa kuripo parizvino.Bioocus inogadzirisa hurongwa hwakakwana hwekurapa murwere wega wega. Kurapa kumwe chete kana kunoverengeka kuchabatanidzwa neTils therapy, izvo zvichawedzera mwero wekushanda kusvika pa80%. Kurapa kwakabatana kunovavarira kuderedza mutoro webundu munguva pfupi, uye tils dzinopa mukana wekuti murwere apore kwenguva refu.

Kunyanya kutsanangurwa: Masero eT-cells anokonzerwa negomarara anonzwa nemaantigens egomarara, anozivikanwa nemaTCR akawanda

Kusasimba kwakasimba kwetsika: Kuratidzwa kwakanyanya kwe chemokine receptors, tropism yakasimba yebundu, uye kushanda nekukurumidza

Kuuraya mabundu: MaTIL anovhurwa uye anowedzerwa kusvika pa109-1011, uye masero ekenza asara anobviswa mushure mekuvhiyiwa.

Mhedzisiro inoenderera mberi: Huwandu hwemasero eT ekurangarira hwakakwira, uye anogona kurarama mumuviri kwenguva yakareba uye achigara achiongororwa.

Kuchengetedzwa kwakanyanya: kubviswa, kuwedzerwa, kusaramba, uye SAE yemasero eTIL kubva kuvarwere pachavo

Kurapa neTils kwakaratidza kushanda zvakanaka mu NSCLC (kenza yemapapu isiri masero madiki),Melanoma, Kenza yemazamu, Kenza yeMuromo weMuromo, uye Kenza yeOvarian. 

Kunze kwekuvhiyiwa kwekubviswa kwebundu rekutanga, tissue yebundu repamusoro, ma lymph nodes, pleural effusion, ascites, nezvimwewo, zvinogonawo kuyedzwa kubviswa. Kurongeka kwekubudirira ndekwekuti: bundu rekutanga ≥ bundu rakapararira ≥ ma lymph nodes ≥ ascites.

Maitiro edu ekurima maTILs akazvimiririra anobudirira kusvika ≥85%. Nemuenzaniso wenyama we ≥1cm3, mabhiriyoni eTILs anogona kurimwa, uye masero anoratidza simba guru re cytotoxic.

1. MaTIL ndiwo masero emurwere, saka hapana njodzi yekurambwa, zvichiita kuti agare akachengeteka.

2. Kukanganisa: Fivha inowanzoonekwa (nekuda kwekuburitswa kwema cytokines panguva yekubviswa kwegomarara mumasero eTILs, zvichikonzera fivha yenguva pfupi, kazhinji isingade kurapwa kwakananga uye inogadziriswa yoga).

3. Zvimwe zviratidzo zvakaipa zvakataurwa muongororo zvinosanganisira thrombocytopenia, febrile neutropenia, BP, nezvimwewo, zvinonyanya kukonzerwa neTILs pamwe chete nemimwe mishonga yakadai se pre-treatment chemotherapy (cyclophosphamide + fluorouracil), high-dose IL-2, PD-1 monoclonal antibodies, nezvimwewo.