Unyango lwe-TIL lutyhilwe: Ukuphonononga imeko-bume ye-Cancer Immunotherapy

Unyango lwe-TIL lubandakanya ukukhupha ii-lymphocytes ezingenela i-tumor (ii-TIL), ezizezona seli zendalo ezichasene ne-tumor emzimbeni wesigulane, kwi-tumor kwaye zityalwe ngobuninzi kwilebhu. Ezi TILs zisebenzayo emva koko zibuyiselwa emzimbeni wesigulane ukuze kuqiniswe amandla enkqubo yomzimba okuzikhusela ekujoliseni nasekubulaleni iiseli zomhlaza. Ii-TIL zisebenza ngokuqaphela iimpawu ezithile kwiiseli zomhlaza kwaye ziqalise impendulo yomzimba okhuselayo kuzo, ekugqibeleni zikhokelela ekutshatyalalisweni kwe-tumor.

Ngokusekelwe kwiziphumo zethu zonyango lwezonyango, ukusebenza kakuhle kwe-TILs monotherapy kufikelela kwi-40%, nto leyo eyenza ukuba ibe yeyona ndlela isebenzayo yonyango lwe-tumor ngaphandle kotyando olukhoyo ngoku. I-Bioocus ilungiselela isicwangciso sonyango esipheleleyo somguli ngamnye. Unyango olunye okanye ezininzi ziya kudityaniswa nonyango lwe-Tils, oluya kunyusa izinga lokusebenza ngokubanzi libe ngaphezulu kwe-80%. Unyango oludibeneyo lujolise ekunciphiseni umthwalo we-tumor kwixesha elifutshane, kwaye i-tils inika ithuba lokuba umguli afumane unyango kwixesha elide.

Ukuchaneka okuphezulu: Iiseli ze-T ezithile zethumba ezivezwa zii-antigen zethumba, eziqatshelwa zii-TCR ezininzi

Uxinzelelo oluqinileyo lwetropikhi: ukubonakaliswa okuphezulu kwee-receptors ze-chemokine, i-tumor tropism enamandla, kunye nesenzo esikhawulezayo

Ukubulala amathumba: Ii-TIL ziyavuselelwa kwaye zandiswe zibe yi-109-1011, kwaye iiseli zomhlaza eziseleyo ziyasuswa emva kotyando.

Isiphumo esiqhubekayo: Umlinganiselo wee-memory T cells uphezulu, kwaye zinokuphila ixesha elide emzimbeni kwaye zihlale zijongiwe rhoqo.

Ukhuseleko oluphezulu: ukukhupha, ukwandisa, ukungabikho kwempendulo yokwaliwa, kunye ne-SAE yeeseli ze-TIL ezivela kwizigulana ngokwazo

Unyango lweTils lubonakalise ukuba lusebenza kakuhle I-NSCLC (umhlaza wemiphunga ongengoweeseli ezincinci),I-Melanoma, Umhlaza Webele, Umhlaza woMlomo, kunye nomhlaza wesibeleko. 

Ngaphandle kotyando lokukhupha ithumba eliphambili, izicubu zethumba elingaphezulu, ii-lymph nodes, i-pleural effusion, i-ascites, njl.njl., nazo zinokuzanywa ukukhupha. Uludwe lwempumelelo lululandelayo: inxeba eliphambili ≥ inxeba elisasazekayo ≥ ii-lymph nodes ≥ ii-ascites.

Inkqubo yethu yokulima ii-TIL eziphuhliswe ngokuzimela ifikelela kwizinga lempumelelo eliyi-≥85%. Ngesampuli eqhelekileyo yezicubu ezi-≥1cm3, iibhiliyoni zee-TIL zinokulinywa, kwaye iiseli zibonisa umsebenzi onamandla we-cytotoxic.

1. Ii-TIL ziiseli zesigulana, ngoko ke akukho mngcipheko wokwaliwa, oqinisekisa ukhuseleko oluphezulu.

2. Iimpendulo ezingalunganga: Umkhuhlane uqhelekile (ngenxa yokukhululwa kwee-cytokines ngexesha lokususwa kwethumba okubangelwa ziiseli ze-TIL, okubangela umkhuhlane wexesha elifutshane, odla ngokungadingi nyango luthile kwaye uphela ngokwawo).

3.Ezinye iziphumo ezimbi ezixeliweyo kwizifundo ziquka i-thrombocytopenia, i-febrile neutropenia, uxinzelelo lwegazi oluphezulu, njl.njl., ikakhulu ezibangelwa yi-TILs xa zidityaniswe nezinye iziyobisi ezifana ne-chemotherapy yangaphambi konyango (cyclophosphamide + fluorouracil), i-IL-2 enedosi ephezulu, ii-antibodies ze-PD-1 monoclonal, njl.njl.