Chithandizo cha TIL Chavumbulutsidwa: Kufufuza Malo a Khansa Yothandizira Kuchiza Khansa

Chithandizo cha TIL chimaphatikizapo kuchotsa ma lymphocyte olowa m'thupi (TILs), omwe ndi maselo enieni achilengedwe olimbana ndi chotupa m'thupi la wodwalayo, kuchokera ku chotupa ndikuchikulitsa mochuluka mu labu. Ma TIL oyambitsidwa awa amabwezeretsedwanso m'thupi la wodwalayo kuti alimbikitse mphamvu ya chitetezo cha mthupi yolimbana ndi kupha maselo a khansa. Ma TIL amagwira ntchito pozindikira zizindikiro zinazake pa maselo a khansa ndikuyambitsa chitetezo cha mthupi motsutsana nawo, zomwe pamapeto pake zimapangitsa kuti chotupa chiwonongeke.

Kutengera ndi zotsatira zathu zachipatala, mphamvu yonse ya monotherapy ya TILs imafika pa 40%, zomwe zimapangitsa kuti ikhale njira yothandiza kwambiri yochizira chotupa kupatula opaleshoni yomwe ilipo pakadali pano. Bioocus imapanga dongosolo lathunthu la chithandizo cha wodwala aliyense payekha. Chithandizo chimodzi kapena zingapo zidzaphatikizidwa ndi chithandizo cha Tils, zomwe zidzawonjezera kuchuluka kwa chithandizo chogwira ntchito mpaka kupitirira 80%. Chithandizo chophatikizanachi cholinga chake ndi kuchepetsa kuchuluka kwa chotupa pakapita nthawi, ndipo tils imapereka mwayi kwa wodwalayo kuti achiritsidwe pakapita nthawi.

Kufotokozera kwakukulu: Maselo a T enieni a chotupa omwe amakhudzidwa ndi ma antigen a chotupa, omwe amadziwika ndi ma TCR angapo

Kuchuluka kwa tropism: Kuchuluka kwa ma chemokine receptors, kuchuluka kwa chotupa, komanso kuchitapo kanthu mwachangu

Kupha zotupa: Ma TIL amayatsidwa ndikukulitsidwa kufika pa 109-1011, ndipo maselo otsala a khansa amachotsedwa pambuyo pa opaleshoni.

Zotsatira zopitilira: Chiwerengero cha maselo a T okumbukira ndi chachikulu, ndipo amatha kukhalabe ndi moyo m'thupi kwa nthawi yayitali ndikuyang'aniridwa nthawi zonse.

Chitetezo chapamwamba: kuchotsa, kukulitsa, palibe kukana, ndi SAE ya maselo a TIL kuchokera kwa odwala okha

Chithandizo cha Tils chakhala chothandiza kwambiri NSCLC (khansa ya m'mapapo yopanda maselo ang'onoang'ono),Khansa ya m'mawere, Melanoma, Khansa ya pachibelekero, ndi Khansa ya M'chiberekero. 

Kupatula kuchotsa chotupa chachikulu pa opaleshoni, minofu ya chotupa chapamwamba, ma lymph nodes, pleural effusion, ascites, ndi zina zotero, zingayesedwenso kuchotsa. Kuchuluka kwa mphamvu ndi motere: chotupa choyamba ≥ chotupa chofalikira ≥ ma lymph nodes ≥ ascites.

Njira yathu yolima ma TIL yomwe idapangidwa payokha imakwaniritsa chiwongola dzanja cha ≥85%. Ndi chitsanzo chabwinobwino cha minofu ya ≥1cm3, ma TIL mabiliyoni ambiri amatha kulimidwa, ndipo maselo amasonyeza mphamvu yamphamvu ya cytotoxic.

1. Ma TIL ndi maselo a wodwalayo, kotero palibe chiopsezo chokana, zomwe zimatsimikizira chitetezo chapamwamba.

2. Zotsatira zoyipa: Malungo amapezeka kawirikawiri (chifukwa cha kutulutsidwa kwa ma cytokines panthawi ya TILs cell-cause of the fibrosis, zomwe zimayambitsa malungo osakhalitsa, nthawi zambiri osafunikira chithandizo chapadera ndipo amatha okha).

3. Zotsatira zina zoyipa zomwe zanenedwa mu kafukufukuyu ndi monga thrombocytopenia, febrile neutropenia, kuthamanga kwa magazi, ndi zina zotero, zomwe nthawi zambiri zimachitika chifukwa cha ma TILs ophatikizidwa ndi mankhwala ena monga chemotherapy isanayambe chithandizo (cyclophosphamide + fluorouracil), IL-2 yochuluka, ma antibodies a monoclonal a PD-1, ndi zina zotero.