Magulu a Chithandizo

Mankhwala Odziwika

Kufalitsa Large B-cell lymphoma (DLBCL)-04

Chithandizo cha CAR-T cha Myasthenia Gravis (MG)

Chithandizo cha Kachilombo ka Oncolytic: Chithandizo Chapamwamba cha Khansa

Mnyamata akuvutika ndi khansa ya m'magazi ya acute lymphoblastic

Kugonjetsa Lymphoma Yaikulu ya B-Cell ndi Bioocus Dual CAR-T Therapy

Kulimbana ndi Khansa ya Hepatocellular ndi Bioocus GPC3 CAR-T Therapy

$Yankho Lodabwitsa mu Refractory Multiple Myeloma Pambuyo pa Chithandizo cha Maselo a CAR-T$

Yankho Lodabwitsa mu Refractory Multiple Myeloma Pambuyo pa Chithandizo cha Maselo a CAR-T

Kupambana kwa Madhavan: Kugonjetsa Ubongo wa Glioma ndi Chithandizo cha Bioocus B7H3 CAR-T

Mnyamata wolimba mtima wochokera ku Russia akulimbana ndi neuroblastoma

Munthu wodzipereka wochokera ku India akulimbana ndi khansa ya m'mimba

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CAR-T ya khansa ya chiwindi

Ngati inu kapena wokondedwa wanu mwapezeka ndi khansa ya chiwindi (HCC), mtundu wofala kwambiri wa khansa ya chiwindi, mwina mukufuna njira zamakono zothetsera matendawa ovuta. Mankhwala achikhalidwe monga opaleshoni, chemotherapy, kapena njira zina zothandizira zingakhale zothandiza kwa ena, koma kwa odwala omwe ali ndi matenda apamwamba, njira zatsopano zochiritsira matenda monga CAR-T cell therapy zimapereka njira yapadera popatsa mphamvu chitetezo chanu cha mthupi kuti chizilimbana ndi maselo a khansa bwino. Ku Bioocus, tikuyang'ana chithandizo cha CAR-T ngati gawo la mapulani osamalira odwala mokwanira, pogwiritsa ntchito kafukufuku wopitilira kuti tipereke chiyembekezo pamene tikuyang'ana kwambiri chitetezo ndi moyo wabwino.

Lumikizanani nafe

Chiyambi

Zotsatira Zachipatala ndi Deta

Mankhwala Owonjezera

Kutenga Gawo Lotsatira

Selo ya CAR-T

CAR-T (Chimeric Antigen Receptor T-cell) Chithandizo ndi chithandizo cha chitetezo chamthupi chomwe chikusintha maselo anu a T kuti azindikire bwino ndikuwononga maselo a khansa. Kwa HCC, chithandizochi chimayang'ana mapuloteni enaake pa maselo a khansa, zomwe zingapereke chithandizo chowonjezereka. njira ina yeniyeni kapena chowonjezera ku chithandizo chokhazikika.

Zimaphatikizapo kusonkhanitsa ndi kupanga maselo anu a chitetezo chamthupi mu labu musanawabwezeretse, cholinga chake ndi kukwaniritsa mayankho okhazikika ndi zotsatirapo zochepa za thupi.

Zolinga mu Chithandizo cha CAR-T cha Hepatocellular Carcinoma

Glypican-3 (GPC3) ndi cholinga chachikulu cha chithandizo cha CAR-T mu HCC chifukwa cha kuchuluka kwa maselo a khansa ya chiwindi komanso kupezeka kochepa m'thupi la munthu wamkulu wathanzi.

GPC3 ndi puloteni yomwe imalimbikitsa kukula kwa chotupa mwa kukulitsa njira zolumikizirana monga Wnt, zomwe zimayambitsa kuchulukana kwa khansa. Mwa kulangiza maselo a CAR-T kuti amange GPC3, chithandizochi chimayang'ana kwambiri kuukira kwa chitetezo cha mthupi pa maselo oopsa, ndikuteteza chiwindi kugwira ntchito bwino momwe zingathere. Njira yowunikirayi ndi yofunika kwambiri kwa odwala omwe ali ndi HCC yapamwamba omwe sanayankhepo kale chithandizo.

Momwe Chithandizo cha CAR-T Chimagwirira Ntchito: Njira Yogwirira Ntchito

Njira yogwiritsira ntchito CAR-T therapy idapangidwa kuti igwiritse ntchito ndikukulitsa chitetezo chachilengedwe cha thupi lanu:

ZosonkhanitsaChitsanzo cha maselo anu a T chimapezeka kudzera mu njira yosavuta yotengera magazi.
UinjiniyaMu labu, maselo a T awa amasinthidwa majini kuti awonetse chimeric antigen receptor (CAR) yomwe imazindikira makamaka GPC3 pa maselo a HCC.
Kuyambitsa ndi Kukulitsa: Maselo osinthidwa amakula mochuluka ndipo amathandizidwa kuti akhale amphamvu olimbana ndi khansa.
KulowetsedwaMaselo a CAR-T amabwereranso m'magazi mwanu, komwe amafufuza ndikugwirizana ndi maselo otupa omwe amawonetsa GPC3.
Kuukira: Maselo a CAR-T akamangiriridwa, amatulutsa zizindikiro kuti awononge maselo a khansa, zomwe zingayambitse kuchepa kwa chotupa ndi kuyang'anira chitetezo cha mthupi nthawi zonse.

Njirayi cholinga chake ndi kupereka yankho lokhazikika, ngakhale kuyang'anitsitsa ndikofunikira kuti tithane ndi zotsatira zilizonse zokhudzana ndi chitetezo chamthupi.

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Chithandizo cha CAR-T chochokera ku GPC3 cha khansa ya chiwindi imasonyeza mphamvu yayikulu m'mayesero azachipatala. Mu kafukufuku wathu wa odwala 30 omwe ali ndi HCC yapamwamba ya GPC3-positive omwe adalephera kulandira chithandizo cham'mbuyomu, chiwerengero cha mayankho olondola chinali 56.6%, kuphatikizapo Mayankho osakwanira a 53.3%. Chiŵerengero cha matenda chafika 86.7%, ndi apakatikati kupulumuka kwa miyezi 13 popanda kupita patsogolo ndi moyo wonse wa miyezi 14.6. Mankhwalawa ndi otetezeka, makamaka ndi cytokine release syndrome yochepa komanso zotsatirapo zake zomwe zingatheke. Tikupitirizabe kuyambitsa njira zimenezi kuti tiwonjezere zotsatira za odwala khansa ya chiwindi.

Kuchiza ndi Radiotherapy ya Thupi la Stereotactic (SBRT)

Njira yeniyeniyi yowunikira ma radiation imayang'ana kwambiri zotupa zazing'ono za chiwindi ndi mlingo waukulu m'magawo ochepa, kuchepetsa kukula kwa chotupa ndikuwonjezera kulowa kwa maselo a CAR-T pomwe kuchepetsa kuwonongeka kwa minofu yozungulira chiwindi.

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Kuchotsa Zinthu Zosayenera

Njira zochepetsera kufalikira kwa khansa monga radiofrequency kapena microwave ablation zimawononga minofu ya chotupa kudzera mu kutentha, zomwe zimapangitsa kuti maselo a CAR-T athe kukhudza bwino maselo otsala a khansa.

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Transarterial Chemoembolization (TACE)

Mwa kupereka mankhwala a chemotherapy mwachindunji ku chotupacho kudzera mu mitsempha ya chiwindi ndikuletsa magazi ake, TACE imachepetsa zotupa ndipo imatha kugwirizana ndi CAR-T mwa kufooketsa chitetezo cha khansa ndikuwonjezera chitetezo cha mthupi.

Opaleshoni

Kwa odwala oyenerera, kuchotsa pang'ono chiwindi kungachotse matenda ambiri, zomwe zingathandize CAR-T kuyang'ana kwambiri zotsalira zazing'ono.

Kuphatikiza kumeneku cholinga chake ndi kukonza zotsatira zabwino pamene mukuika patsogolo chitonthozo chanu ndi thanzi la chiwindi.

Mafunso Ofunsidwa Kawirikawiri

Kodi chithandizo cha CAR-T chili choyenera odwala onse a HCC? Kawirikawiri imaganiziridwa kwa anthu omwe ali ndi zotupa za GPC3 omwe apita patsogolo pa chithandizo chamankhwala chokhazikika. Kuwunika bwino, kuphatikizapo kuyezetsa kwa biomarker, kumatsimikiza kuyenerera.
Kodi ndi zotsatirapo zotani zomwe ndingakumane nazo? Zomwe zimafala kwambiri ndi zizindikiro zofanana ndi chimfine kuchokera ku CRS, kutopa, kapena kusintha kwakanthawi kwa ntchito ya chiwindi, zomwe zimawunikidwa ndikuchiritsidwa mwachangu.
Kodi chithandizocho chimatenga nthawi yayitali bwanji? Kuyambira kusonkhanitsa maselo mpaka kulowetsedwa m'thupi, nthawi zambiri zimatenga milungu ingapo, kenako n’kutsatira nthawi zonse kuti aone momwe maselowo akuyendera.

Ngati mukufufuza Chithandizo cha CAR-T chifukwa cha khansa ya chiwindi, gulu lathu ku Bioocus lakonzeka kukambirana momwe lingagwirizanitsire ntchito yanu yosamalira odwala. Lumikizanani nafe kuti mukambirane nafe kuti muwunikenso zomwe mungasankhe pogwiritsa ntchito malangizo ozikidwa pa umboni—ulendo wanu wopita ku kasamalidwe kabwino umayamba ndi zisankho zodziwikiratu.

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