Pawg Kev Kho Mob

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Ib tug tub hluas uas muaj mob leukemia lymphoblastic loj heev

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Kev Kho Mob Hepatocellular Carcinoma nrog Bioocus GPC3 CAR-T Therapy

$Cov Lus Teb Zoo Kawg Nkaus Hauv Refractory Multiple Myeloma Tom Qab CAR-T Cell Therapy$

Cov Lus Teb Zoo Kawg Nkaus Hauv Refractory Multiple Myeloma Tom Qab CAR-T Cell Therapy

Madhavan Txoj Kev Yeej: Kev Yeej Kab Mob Glioma Hauv Hlwb Nrog Bioocus B7H3 CAR-T Therapy

Ib tug tub hluas uas muaj zog los ntawm Russia tawm tsam neuroblastoma

Ib tug txiv neej uas mob siab rau los ntawm Is Nrias teb tawm tsam mob qog noj ntshav hauv plab

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CAR-T rau Hepatocellular Carcinoma

Yog tias koj lossis ib tus neeg koj hlub tau kuaj pom tias muaj mob qog nqaij hlav hepatocellular carcinoma (HCC), uas yog hom mob qog nqaij hlav siab feem ntau, tej zaum koj yuav nrhiav kev xaiv siab dua los tswj tus kab mob nyuaj no. Kev kho mob ib txwm muaj xws li kev phais, kev siv tshuaj kho mob qog nqaij hlav, lossis kev kho mob tsom mus rau ib tus neeg tuaj yeem ua tau zoo rau qee tus, tab sis rau cov neeg mob hnyav, cov kev kho mob tshiab xws li CAR-T cell therapy muab txoj hauv kev rau koj tus kheej los ntawm kev txhawb zog rau koj lub cev tiv thaiv kab mob kom tawm tsam cov qog nqaij hlav zoo dua. Ntawm Bioocus, peb tab tom tshawb nrhiav CAR-T therapy ua ib feem ntawm cov phiaj xwm saib xyuas kev noj qab haus huv, siv kev tshawb fawb txuas ntxiv mus los muab kev cia siab thaum tsom mus rau kev nyab xeeb thiab lub neej zoo.

Tiv tauj peb

Kev Taw Qhia

Cov Txiaj Ntsig Hauv Kev Kho Mob Thiab Cov Ntaub Ntawv

Kev Kho Mob Ntxiv

Ua Kauj Ruam Tom Ntej

CAR-T Cell

CAR-T (Chimeric Antigen Receptor T-cell) kev kho mob yog ib qho kev kho mob tiv thaiv kab mob uas hloov kho koj cov qe ntshav T kom paub zoo dua thiab rhuav tshem cov qe ntshav qog nqaij hlav. Rau HCC, qhov kev kho mob no tsom mus rau cov protein tshwj xeeb ntawm cov qe ntshav qog nqaij hlav, tej zaum yuav muab ntau dua lwm txoj kev xaiv tseeb los yog kev txhawb nqa rau cov kev kho mob txheem.

Nws cuam tshuam nrog kev sau thiab tsim koj cov hlwb tiv thaiv kab mob hauv chav kuaj ua ntej rov ua dua lawv, lub hom phiaj kom ua tiav cov lus teb ruaj khov nrog tsawg dua cov kev mob tshwm sim ntawm lub cev.

Cov Hom Phiaj hauv Kev Kho Mob CAR-T rau Hepatocellular Carcinoma

Glypican-3 (GPC3) yog lub hom phiaj tseem ceeb rau kev kho mob CAR-T hauv HCC vim nws muaj kev qhia ntau ntawm cov hlwb mob qog noj ntshav thiab muaj tsawg heev hauv cov nqaij laus noj qab haus huv.

GPC3 yog ib qho protein ntawm lub cell uas txhawb nqa kev loj hlob ntawm qog nqaij hlav los ntawm kev txhim kho cov kev taw qhia xws li Wnt, uas tsav kev loj hlob ntawm qog nqaij hlav. Los ntawm kev coj cov hlwb CAR-T kom khi GPC3, kev kho mob tsom mus rau kev tawm tsam lub cev tiv thaiv kab mob rau cov hlwb phem, tiv thaiv kev ua haujlwm ntawm lub siab kom ntau li ntau tau. Txoj kev npaj no yog qhov tseem ceeb rau cov neeg mob uas muaj HCC theem siab uas tsis tau teb rau cov kev kho mob yav dhau los.

Kev Kho Mob CAR-T Ua Haujlwm Li Cas: Lub Txheej Txheem Ua Haujlwm

Cov txheej txheem ntawm CAR-T kev kho mob yog tsim los siv thiab ua kom koj lub cev tiv thaiv kab mob zoo dua:

Cov khoom sauIb qho qauv ntawm koj cov qe ntshav T yog tau los ntawm kev siv cov txheej txheem yooj yim zoo li kev rho ntshav.
Kev Tsim KhoHauv chav kuaj, cov qe ntshav T no tau hloov kho caj ces kom qhia txog tus chimeric antigen receptor (CAR) uas paub txog GPC3 ntawm cov qe ntshav HCC.
Kev Ua Kom Muaj Zog thiab Kev Nthuav DavCov hlwb uas tau hloov kho lawm loj hlob ntau heev thiab ua kom muaj zog los ua cov neeg tawm tsam mob qog noj ntshav.
Kev txhaj tshuajCov qe ntshav CAR-T raug muab rov qab rau hauv koj cov ntshav, qhov chaw uas lawv nrhiav thiab khi rau cov qe ntshav qog GPC3.
Kev Tawm TsamThaum khi, cov qe ntshav CAR-T tso tawm cov cim los rhuav tshem cov qe ntshav qog, uas tej zaum yuav ua rau muaj kev txo qis ntawm cov qog thiab kev saib xyuas kev tiv thaiv kab mob tas mus li.

Lub hom phiaj no yog los muab kev teb rov qab tas mus li, txawm hais tias kev saib xyuas ze yog qhov tseem ceeb los tswj cov teebmeem cuam tshuam nrog kev tiv thaiv kab mob.

Daim duab qhia txog lub hauv paus ntsiab lus ntawm CAR-T.jpg

Kev kho mob CAR-T uas tsom mus rau GPC3 rau mob qog nqaij hlav siab qhia tau tias muaj zog ua tau zoo hauv kev sim tshuaj. Hauv peb txoj kev tshawb nrhiav ntawm 30 tus neeg mob uas muaj HCC GPC3-positive uas tau ua tsis tiav cov kev kho mob yav dhau los, qhov Tus nqi teb lus ncaj ncees yog 56.6%, suav nrog 53.3% cov lus teb ib nrab. Tus nqi tswj kab mob tau mus txog 86.7%, nrog rau nruab nrab kev muaj sia nyob tsis muaj kev nce qib ntawm 13 lub hlis thiab tag nrho cov ciaj sia taus ntawm 14.6 lub hlis. Kev kho mob no muaj kev nyab xeeb, feem ntau yog mob cytokine tso tawm me me thiab cov kev mob tshwm sim uas tswj tau. Peb txuas ntxiv ua cov kev kho mob no los txhim kho cov txiaj ntsig rau cov neeg mob qog noj ntshav hauv siab.

Kev Kho Mob Hluav Taws Xob Stereotactic Lub Cev (SBRT)

Cov txheej txheem hluav taws xob no yog siv rau cov qog nqaij me me hauv daim siab nrog cov koob tshuaj ntau hauv ob peb zaug, ua rau cov qog nqaij me me thiab ua rau cov qe ntshav CAR-T nkag mus rau hauv cov hlwb thaum txo qhov kev puas tsuaj rau cov nqaij ntawm daim siab ib puag ncig.

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Kev Kho Mob Ablation

Cov txheej txheem minimally invasive xws li radiofrequency lossis microwave ablation rhuav tshem cov ntaub so ntswg mob qog noj ntshav los ntawm cua sov, tsim ib puag ncig uas CAR-T cell tuaj yeem tsom mus rau cov cell qog noj ntshav uas tseem tshuav tau zoo dua.

Duab cog rau hauv qhov chaw mos.png

Kev Siv Tshuaj Kho Mob Los Ntawm Kev Siv Tshuaj ...

Los ntawm kev xa tshuaj chemotherapy ncaj qha mus rau lub qog nqaij hlav ntawm cov hlab ntsha hauv siab thiab thaiv nws cov ntshav, TACE ua rau cov qog nqaij hlav me me thiab tej zaum yuav ua haujlwm nrog CAR-T los ntawm kev ua kom lub cev tiv thaiv kab mob qog nqaij hlav tsis muaj zog thiab txhim kho kev tiv thaiv kab mob.

Kev phais mob

Rau cov neeg mob uas tsim nyog, kev phais daim siab ib nrab tuaj yeem tshem tawm cov kab mob loj, ua rau CAR-T tsom mus rau cov seem me me.

Cov kev sib xyaw ua ke no tsom mus rau qhov ua kom tau txiaj ntsig zoo tshaj plaws thaum tseem muab qhov tseem ceeb rau koj qhov kev nplij siab thiab kev noj qab haus huv ntawm lub siab.

Cov Lus Nug Feem Ntau

Kev kho mob CAR-T puas haum rau txhua tus neeg mob HCC? Feem ntau nws yog suav nrog rau cov neeg uas muaj cov qog GPC3-positive uas tau nce qib ntawm cov kev kho mob ib txwm muaj. Kev ntsuam xyuas kom meej, suav nrog kev kuaj biomarker, txiav txim siab seb puas tsim nyog.
Kuv yuav muaj tej yam tshwm sim tsis zoo li cas? Cov tsos mob uas pom ntau muaj xws li cov tsos mob zoo li mob khaub thuas los ntawm CRS, qaug zog, lossis kev hloov pauv ntawm lub siab ua haujlwm ib ntus, uas yuav tsum tau saib xyuas thiab kho sai.
Cov txheej txheem kho mob ntev npaum li cas? Txij li thaum khaws cov cell mus txog rau thaum muab cov tshuaj txhaj rau hauv cov hlab ntshav, feem ntau yuav siv sijhawm ob peb lub lis piam, tom qab ntawd yuav tsum tau mus soj ntsuam tas li kom paub tseeb tias cov tshuaj teb rau cov tshuaj ntawd.

Yog koj tab tom tshawb nrhiav Kev kho mob CAR-T rau mob qog nqaij hlav hauv siab, peb pab neeg ntawm Bioocus npaj txhij los tham txog seb nws yuav koom ua ke li cas rau hauv koj txoj kev npaj kho mob. Hu rau kev sab laj los tshuaj xyuas koj cov kev xaiv nrog cov lus qhia raws li pov thawj - koj txoj kev mus rau kev tswj hwm zoo dua pib nrog kev xaiv paub.

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