Kev Kho Mob CAR-T rau Kev Rov Qab Los/Refractory Neuroblastoma

Kev kho mob GD2 CAR-Tyog ib txoj kev kho mob tshiab uas hloov kho tus neeg mob cov qe ntshav T kom paub thiab tawm tsam cov qe ntshav neuroblastoma uas qhia tawm GD2 antigen. Txoj kev kho mob no yog tsim tshwj xeeb rau cov neeg mob uas rov qab mob lossis tsis kho tau tus kab mob neuroblastoma uas muaj kev pheej hmoo siab thiab tau pom tias muaj txiaj ntsig zoo hauv kev sim tshuaj.

• Xwm txheej ntawm tus kab mobKab mob neuroblastoma uas muaj kev pheej hmoo siab nrog rau kab mob uas kav ntev, rov qab mob dua, lossis mob zuj zus tom qab kev kho mob thawj kab.

• Cov Yam Ntxivkab mob kis mus rau lwm qhov, MYCN amplification, lossis kev tsis kam rau cov kev kho mob ib txwm muaj.

Cov Kauj Ruam Tseem Ceeb

1. Kev kho ua ntej: Lymphodepletion ua ntej infusion.

2. Kev txhaj tshuajKev ntsuas qhov tseeb ntawm cov qe ntshav GD2-CAR-T (pom zoo: 10 × 10^6 CAR-positive T cell/kg).

3. Kev ua raws liKev thaij duab tsis tu ncua (PET/CT, MRI) thiab kev ntsuam xyuas pob txha tom qab txhaj tshuaj.

Cov Txiaj Ntsig Kho Mob

• Tus Nqi Teb33% tau txais kev zam txim tag nrho (CR), nrog rau qhov feem pua ​​​​​​ntawm kev teb tag nrho (CR + PR) ntawm 63%.

• Kev ciaj siaKev ciaj sia nyob tau 3 xyoos (OS) yog 60% thiab kev ciaj sia tsis muaj teeb meem dab tsi (EFS) yog 36% ntawm cov tshuaj uas tau pom zoo.

• Cov Ntaub Ntawv Kev Nyab XeebFeem ntau cov teeb meem tshwm sim tsis zoo uas tshwm sim tau yog Qib 1-2 cytokine release syndrome (74%).

Peb Qhov Zoo

• Tsheb CAR tiam 3Ob lub co-stimulatory domains (CD28 + 4-1BB) ua rau T-cell muaj zog thiab nyob ntev dua.

• Kev Nyab Xeeb Hloov: Kev sib xyaw ua ke ntawm iC9 gene tso cai rau kev tswj hwm sai ntawm kev lom yog tias xav tau.

• Cov Ntaub Ntawv Pov Thawj: Tau ua pov thawj tias muaj kev vam meej hauv kev sim tshuaj nrog cov ntaub ntawv soj ntsuam ntev.