- Kev Kho Mob
- Cov Lus Pov Thawj
- Neuroblastoma
- Mob qog khov kho
- Cov Lus Pov Thawj
- TILS
- Kev Kho Mob NK Cell
- Myasthenia Gravis (MG)
- Kab mob qog ntshav Lymphoblastic loj heev (B-ALL)
- Kab mob Lupus Erythematosus (SLE)
- Kab mob qog ntshav Lymphoblastic mob hnyav (T-ALL)
- Cov kab mob qog nqaij hlav tsis yog Hodgkin (NHL)
- Ntau yam mob myeloma (MM)
- Diffuse Large B-cell Lymphoma
- Kab mob B-lymphocytic Leukemia
- Mob qog nqaij hlav
CAR-T rau Glioblastoma
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CAR-T Cell
Kev kho mob CAR-T (Chimeric Antigen Receptor T-cell) yog ib hom kev kho mob tiv thaiv kab mob uas tshiab heev. Nws suav nrog kev hloov kho koj tus kheej cov T cell—ib hom cell tiv thaiv kab mob—kom paub thiab tawm tsam cov cell mob qog noj ntshav uas qhia cov cim tshwj xeeb. Rau glioblastoma, txoj kev kho mob no lub hom phiaj yog muab kev kho mob rau tus kheej uas yuav ua rau muaj sia nyob ntev dua thiab txo cov tsos mob, tshwj xeeb tshaj yog thaum ua ke nrog lwm yam kev kho mob.
Cov Hom Phiaj hauv CAR-T Kev Kho Mob rau Glioblastoma
Hauv glioblastoma, qee cov protein nyob rau ntawm qhov chaw ntawm cov qog nqaij hlav ua lub hom phiaj zoo tshaj plaws rau kev kho mob CAR-T vim lawv qhov kev qhia ntau dhau ntawm cov qog nqaij hlav thiab muaj tsawg ntawm cov nqaij noj qab haus huv. Ntawm Bioocus, peb tsom mus rau ob lub hom phiaj tseem ceeb:
- GD2Qhov no yog ib qho glycolipid antigen uas feem ntau pom muaj nyob rau ntawm cov hlwb glioblastoma, nrog rau lwm cov qog hauv hlwb xws li diffuse midline gliomas. GD2 koom nrog hauv kev xa xov ntawm cov hlwb thiab pom tseeb heev hauv cov qog nqaij hlav uas tawm tsam hnyav, ua rau nws yog ib qho cim qhia zoo rau kev tsom mus rau kev tiv thaiv kab mob.
- B7-H3Kuj hu ua CD276, cov protein no yog qhov ua rau lub cev tiv thaiv kab mob tsis muaj zog hauv glioblastoma thiab ua rau lub cev tiv thaiv kab mob tsis tuaj yeem tiv thaiv tau. Nws ua lub luag haujlwm tseem ceeb hauv kev txhawb nqa kev loj hlob ntawm mob qog noj ntshav thiab tiv thaiv kev teb ntawm lub cev tiv thaiv kab mob, uas ua rau nws yog lub hom phiaj zoo rau kev txhawb nqa kev tawm tsam T-cell.
Los ntawm kev tsim cov hlwb CAR-T kom paub txog GD2 lossis B7-H3, kev kho mob coj mus rau kev tawm tsam rau cov hlwb qog nqaij hlav thaum txo qis kev puas tsuaj rau cov ntaub so ntswg ntawm lub hlwb.
Kev Kho Mob CAR-T Ua Haujlwm Li Cas: Lub Txheej Txheem Ua Haujlwm
Kev kho mob CAR-T pib nrog kev sau cov qauv ntawm koj cov qe ntshav T los ntawm cov txheej txheem zoo ib yam li kev pub ntshav. Cov qe ntshav no tom qab ntawd raug hloov kho caj ces hauv chav kuaj mob kom qhia txog tus chimeric antigen receptor (CAR) - tus receptor uas ua haujlwm zoo li "homing device" rau cov qe ntshav qog noj ntshav.
- Kev lees paubTus CAR ntawm cov qe ntshav T khi tshwj xeeb rau GD2 lossis B7-H3 ntawm cov qe ntshav glioblastoma, zoo li lub xauv thiab tus yuam sij.
- Kev ua kom rov ua duaThaum twg khi tau lawm, CAR yuav ua rau cov T cell ua haujlwm, nthuav dav, thiab tso tawm cov cim qhia uas sib sau ua ke lwm cov cell tiv thaiv kab mob kom koom nrog kev sib ntaus.
- Kev puas tsuajCov qe ntshav T uas qhib lawm ncaj qha tawm tsam thiab tua cov qe ntshav qog uas raug tsom mus rau, ua rau cov qog nqaij hlav me dua thiab txo cov kab mob.
Cov txheej txheem no feem ntau yuav tsum tau txhaj cov qe ntshav T uas tau hloov kho rov qab rau hauv koj lub cev, feem ntau yog los ntawm kev txhaj tshuaj rau hauv cov hlab ntsha lossis cov txheej txheem xa mus rau lub hlwb. Lub hom phiaj yog los tsim kom muaj kev tiv thaiv kab mob uas txuas ntxiv saib xyuas thiab tshem tawm cov qe ntshav qog uas tseem tshuav dhau sijhawm.
Peb cov kev kho mob CAR-T tsom mus rau GD2 thiab B7-H3 rau Glioblastomaua pov thawj tias muaj txiaj ntsig zoo hauv kev sim tshuaj.
Rau GD2 CAR-T, kev tshawb fawb ntawm 37 tus neeg mob uas muaj cov gliomas qib siab rov qab los yog tsis kho tau qhia txog 72% tus nqi teb raws li lub hom phiaj, nrog 42% ua tiav kev zam txim tag nrho ntawm 6 lub lis piam thiab 56% tswj hwm nws ntawm 1.7 xyoo kev saib xyuas tom qab.
Rau B7-H3 CAR-T, kev sim ntawm 39 tus neeg laus uas muaj glioblastoma rov tshwm sim tau tshaj tawm tias 30–40% feem pua teb thiab 60–70% ntawm kev tswj kab mob, nrog Lub neej nruab nrab ntawm 11 lub hlis (kev kho mob monotherapy) thiab 13.6 lub hlis (kev sib xyaw ua ke), dhau cov ntaub ntawv keeb kwm.
Ob txoj kev kho mob no muaj kev nyab xeeb, nrog rau cov kev mob tshwm sim me me, thiab tswj tau. Bioocus mob siab rau kev txhim kho cov kev kho mob tshiab no kom txhim kho cov txiaj ntsig rau cov neeg mob glioblastoma.
Kev Kho Mob Hluav Taws Xob
Kev kho mob hluav taws xob Stereotactic (SRT) los yog Kev kho mob stereotactic lub cev (SBRT) siv tau ua ke nrog CAR-T los tsom mus rau thaj chaw mob qog nqaij hlav kom meej, txo qhov loj me thiab ua kom cov hlwb tiv thaiv kab mob nkag mus tau zoo dua. Txoj kev no ua tau zoo heev thiab txo qhov puas tsuaj rau cov nqaij noj qab haus huv thiab tej zaum yuav ua rau CAR-T nkag mus tau zoo dua.
Cov Txheej Txheem Tiv Thaiv
Kev cog cov khoom me me cuam tshuam nrog kev muab cov khoom siv hluav taws xob ncaj qha rau hauv qhov mob qog noj ntshav rau kev siv hluav taws xob hauv zos, ua kom CAR-T ua kom cov hlwb qog noj ntshav tsis muaj zog ua ntej. Rau kev nkag mus rau lub hlwb, Ommaya lub pas dej qhov chaw tso cai rau kev xa cov tshuaj ncaj qha mus rau hauv cov kua dej cerebrospinal, tej zaum yuav ua rau CAR-T faib tawm zoo dua.
Lub pas dej Ommaya
Lub cuab yeej tshwj xeeb no, phais muab tso rau hauv qab lub taub hau, tso cai rau kev xa cov tshuaj ncaj qha mus rau hauv cov kua dej cerebrospinal los ntawm lub catheter mus rau lub hlwb ventriclesRau cov neeg mob glioblastoma, tshwj xeeb tshaj yog cov neeg uas muaj leptomeningeal kis, Lub chaw khaws dej Ommaya ua rau muaj kev tswj hwm cov hlwb CAR-T lossis lwm yam kev kho mob kom raug, xyuas kom meej tias muaj cov tshuaj ntau dua hauv lub paj hlwb hauv nruab nrab nrog qhov tsis xis nyob tsawg kawg nkaus piv rau kev punctures lumbar.
Lub tswv yim ntau hom no lub hom phiaj yog ua kom loj tshaj plaws tswj tus kab mob thaum txhawb nqa koj txoj kev zoo thiab kev noj qab haus huv.
Cov Lus Nug Feem Ntau
- Kuv puas tsim nyog tau txais kev kho mob CAR-T?Kev tsim nyog tau txais kev kho mob nyob ntawm seb muaj pes tsawg yam xws li hom qog nqaij hlav, kev kho mob yav dhau los, thiab kev noj qab haus huv tag nrho. Kev sab laj nrog peb cov kws tshwj xeeb tuaj yeem pab txiav txim siab seb nws puas haum rau koj.
- Tej yam tshwm sim tsis zoo li cas?Cov uas feem ntau muaj xws li qaug zog, cov tsos mob ntsig txog kev o, thiab cov tshuaj tiv thaiv kab mob, uas tau saib xyuas thiab tswj hwm ze.
- Cov txheej txheem no siv sijhawm ntev npaum li cas?Txij li thaum sau cov cell mus txog rau thaum muab infusion, feem ntau nws siv sijhawm ntau lub lis piam, nrog rau kev saib xyuas tom qab.
Yog koj xav txog Kev kho mob CAR-T rau glioblastoma, peb nyob ntawm no los txhawb koj nrog kev khuv leej, kev saib xyuas raws li pov thawj. Tiv tauj peb pab neeg ntawm Bioocus los teem sijhawm sab laj thiab kawm seb txoj hauv kev tshiab no yuav haum rau koj txoj kev npaj kho mob li cas. Koj txoj kev noj qab haus huv thiab kev cia siab tseem ceeb rau peb - cia peb tshawb nrhiav cov kev xaiv ua ke.
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