- Kev Kho Mob
- Cov Lus Pov Thawj
- Neuroblastoma
- Mob qog khov kho
- Cov Lus Pov Thawj
- TILS
- Kev Kho Mob NK Cell
- Myasthenia Gravis (MG)
- Kab mob qog ntshav Lymphoblastic loj heev (B-ALL)
- Kab mob Lupus Erythematosus (SLE)
- Kab mob qog ntshav Lymphoblastic mob hnyav (T-ALL)
- Cov kab mob qog nqaij hlav tsis yog Hodgkin (NHL)
- Ntau yam mob myeloma (MM)
- Diffuse Large B-cell Lymphoma
- Kab mob B-lymphocytic Leukemia
- Mob qog nqaij hlav
Kev Kho Mob CAR-T rau Myasthenia Gravis (MG)
Txheej txheem cej luam
Myasthenia Gravis (MG) yog ib qho mob autoimmune neuromuscular disorder uas tshwm sim los ntawm autoantibodies (feem ntau yog anti-acetylcholine receptor antibodies, AchRAb) uas ua rau kev sib txuas lus ntawm cov hlab ntsha thiab cov leeg tsis zoo, ua rau qaug zog, mob pob qij txha, ua tsis taus pa, thiab thaum mob hnyav ua rau ua tsis taus pa. Rau cov neeg mob uas muaj MG uas tsis kho tau thiab tsis ua haujlwm nrog cov tshuaj immunosuppressive, IVIG, FcRn inhibitors, thiab complement inhibitors, cov kev kho mob tseem tsawg.
BIOOCUS txoj kev kho mob CD19/BCMA CAR-T uas siv ob lub hom phiaj yog kev kho mob hlwb autologous uas tshem tawm cov hlwb B thiab cov hlwb plasma uas ua rau muaj kev tsim cov tshuaj tiv thaiv kab mob, muab lub peev xwm rau kev zam txim tob thiab ruaj khov hauv MG uas nyuaj kho.
Kev Kho Mob CAR-T rau MG yog dab tsi?
Kev kho mob CAR-T rau MG yog ib qho kev kho mob tiv thaiv kab mob uas tus neeg mob tus kheej tau tsim kho kom pom cov chimeric antigen receptors (CARs) uas tsom mus rau CD19 (ntawm B hlwb) thiab BCMA (ntawm plasma hlwb). Tom qab nthuav dav hauv chav kuaj, cov hlwb CAR-T ob lub hom phiaj no tau muab rov qab rau hauv tus neeg mob, qhov chaw uas lawv xaiv cov hlwb tiv thaiv kab mob autoreactive uas tsav MG, ua li no txo cov qib AchRAb thiab rov qab ua haujlwm ntawm cov leeg nqaij.
Txoj kev kho mob ob hom no hais txog ob qho tib si cov hlwb thiab cov humoral ntawm cov lus teb autoimmune, muab kev pib dua ntawm lub cev tiv thaiv kab mob ntau dua piv rau ib hom lossis kev kho mob ib txwm muaj.
Cov txiaj ntsig tseem ceeb ntawm CAR-T Therapy rau MG
- Kev txhim kho cov tsos mob sai thiab ntev: Txo tau qhov mob nqaij qaug zog, mob pob qij txha, mob diplopia, mob dysarthria, thiab mob ceg qaug zog.
- Kev puas tsuaj ntawm B-cell thiab plasma-cell tob: Kev txo qis ntawm AchRAb thiab tag nrho cov B-lymphocyte suav tau pom tseeb thiab kav ntev.
- Cov qhab nia kho mob zoo duaCov qhab nia ntawm Quantitative Myasthenia Gravis (QMG) thiab Activities of Daily Living (ADL) tau nce ntau heev.
- Cov ntaub ntawv kev nyab xeeb zoo: Zoo rau kev siv thiab tsis muaj cytokine release syndrome (CRS) lossis neurotoxicity pom muaj nyob rau hauv cov neeg mob uas tau kho.
- Muaj peev xwm ua rau lub sijhawm ntev rov qab zoo li qubTxo lossis tshem tawm qhov xav tau kev tiv thaiv kab mob mus ntev.
- Kho kom haum tus kheej thiab meejSiv cov hlwb ntawm tus neeg mob, txo qhov kev pheej hmoo ntawm kev tsis lees txais.
Cov Txheej Txheem Kho Mob
- Kev kho mob Leukapheresis- Kev sau cov qe ntshav T ntawm tus neeg mob los ntawm kev siv cov ntshav apheresis.
- Kev Tsim Kho Genetic- Cov qe ntshav T raug hloov kho kom qhia tawm CD19 thiab BCMA CARs thiab nthuav dav hauv cov chaw GMP.
- Kev kho mob (yog tias xav tau)- Kev txiav cov lymphodepletion luv luv kom zoo dua rau CAR-T engraftment.
- CAR-T Infusion– Ib zaug txhaj tshuaj CD19 CAR-T rau hauv cov hlab ntsha (0.5×10⁶/kg) + BCMA CAR-T (1×10⁶/kg).
- Kev Saib Xyuas & Kev Ua Raws Li– Kev ntsuam xyuas tsis tu ncua ntawm kev nthuav dav CAR-T, cov qib AchRAb, cov lej B-cell, cov qhab nia QMG/ADL, thiab kev ua haujlwm ntawm cov kabmob rau txog li 12+ lub hlis.
Vim li cas ho xaiv BIOOCUS's CAR-T Therapy rau MG?
- Lub platform CAR-T dual-target CD19/BCMA uas tshiab tshaj plaws thiab tau tsim tshwj xeeb rau cov kab mob autoimmune.
- Kev tsim khoom GMP thoob ntiaj teb thiab pab pawg neeg kho mob tiv thaiv kab mob uas muaj kev paub dhau los nrog kev txawj ntse hauv ob qho tib si hematologic malignancies thiab refractory autoimmune mob.
- Kev txhawb nqa cov neeg mob thoob ntiaj teb: kev sib koom tes ntau hom lus, kev thauj mus los hauv tshav dav hlau, chaw nyob, thiab kev saib xyuas mus sij hawm ntev.
- Cov ntaub ntawv pov thawj hauv CAR-T rau cov kab mob autoimmune (suav nrog SLE) thiab kev npaj kho mob tus kheej.
- Kev saib xyuas tag nrho txij li kev ntsuam xyuas ua ntej kev kho mob mus rau kev saib xyuas tom qab kev txhaj tshuaj.
Cov Ntaub Ntawv Kawm Txog Tus Neeg Mob Qhov Tseem Ceeb: Poj Niam Muaj Hnub Nyoog 20 Xyoo (LYN) uas Muaj Tshuaj MG Uas Tsis Txawj Kho
Keeb Kwm ntawm Tus Neeg Mob
- Kuaj pom tias muaj tus kab mob Myasthenia Gravis uas tsis khov kho (CNGIIIa, AchRAb-positive) thiab muaj tus kab mob thymoma/thymic hyperplasia tom qab phais B3.
- Cov kab mob sib koom ua ke: osteoporosis, ob sab ntawm lub taub hau femoral thiab sab laug proximal tibial avascular necrosis, anemia vim tsis muaj hlau.
- Kev kho mob ntau txoj kab tsis ua tiav (2019–2025): cov tshuaj steroids ntau + azathioprine → tacrolimus → cyclosporine, rov ua IVIG, efgartigimod, eculizumab + telitacicept, thiab rituximab (500 mg, tsis ua haujlwm).
Kev Kho Mob CAR-T
- Kaum Ib Hlis 2025: CAR-T protocol pib siv; cyclosporine raug ncua tseg.
- Lub Kaum Ob Hlis 1, 2025: Kev sau cov qe ntshav dawb mononuclear.
- Lub Kaum Ob Hlis 15, 2025: Kev txhaj tshuaj ntawm CD19 CAR-T (0.5 × 10⁶ / kg) + BCMA CAR-T (1 × 10⁶ / kg).
- Tsis muaj tej yam tsis zoo tshwm sim pom tom qab infusion.
Cov Txiaj Ntsig Tom Qab Kev Kho Mob (txij li Lub Peb Hlis 2026)
- Kev nthuav dav ntawm CAR-T: Kev nthuav dav sai hauv vivo nrog lub ncov CD19 CAR-T ntawm D10 (7.62%, 4.622 × 10⁷ / L) thiab BCMA CAR-T ntawm D10 (17.17%, 1.0414 × 10⁸ / L); kev kuaj pom txuas ntxiv mus txog Lub Hlis 3.
- Kev Txhim Kho Hauv Chaw Kuaj Mob:
- Txo qis dua ntawm AchRAb theem thiab tag nrho cov B-lymphocyte suav.
- Cov lej ntshav ruaj khov, lub siab thiab lub raum ua haujlwm.
- Cov theem ntawm immunoglobulin raug saib xyuas (kev hloov pauv ib ntus yuav tshwm sim vim yog B-cell poob qis).
- Cov Qhab Nia Kho Mob: Kev txhim kho zoo hauv QMG thiab ADL cov qhab nia, uas qhia txog kev txo qis cov leeg nqaij qaug zog thiab kev ua haujlwm txhua hnub zoo dua.
- Kev Pab Cuam Rau Cov tsos mobKev daws teeb meem lossis kev txhim kho zoo hauv diplopia, lub ntsej muag tawv, dysarthria, thiab ceg qaug zog.
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