Ib tug txiv neej uas mob siab rau los ntawm Is Nrias teb tawm tsam mob qog noj ntshav hauv plab

Muaj ib tug txiv neej uas muaj lub siab tawv hu ua Thirandas Shiva Prasad. Nws muaj 32 xyoo, thiab nws tuaj ntawm Is Nrias teb. Vim li cas peb thiaj hais txog nws txoj kev txiav txim siab? Nov yog nws zaj dab neeg zoo kawg nkaus.

Xyoo 2023, Thirandas tau kuaj pom tias muaj mob qog nqaij hlav hauv plab, nws mob plab thiab pom tseeb tias yog mob qog nqaij hlav qis. Nws tau phais mob qog nqaij hlav neoadjuvant nrog FLOT regimen, ua raws li kev phais mob suav nrog subtotal gastrectomy. Txawm hais tias muaj kev kho mob tom qab phais mob, mob qog nqaij hlav rov tshwm sim nrog metastases mus rau lub plab mog, ua rau muaj teeb meem xws li hydronephrosis, abscesses, thiab obstructions. Nws tau nyiaj ntau yam kev cuam tshuam, suav nrog dialysis, stenting, thiab ntxiv chemo nrog nab-paclitaxel, nivolumab, irinotecan, thiab lwm yam. Los ntawm xyoo 2025, PET-CT scans qhia tau tias muaj kev nce qib nrog cov kab mob plab thiab ascites ntau ntxiv, ua rau nws xav tau cov kev xaiv tshiab.

Nrhiav kev kho mob tshiab, Thirandas tig mus rau BIOOCUS. Peb pab neeg kws tshaj lij tau muab kev ntsuam xyuas thawj zaug dawb, tshuaj xyuas nws keeb kwm ntev thiab pom zoo CLDN18.2 CAR-T cell therapy, uas haum rau nws qhov mob qog nqaij hlav. Tom qab preconditioning, qhov infusion tau ua tiav zoo hauv peb lub chaw kho mob siab heev. Txawm hais tias muaj teeb meem thawj zaug xws li kub taub hau thiab muaj peev xwm kis kab mob, peb pab neeg ntau yam kev kawm tau tswj cov tsos mob zoo nrog cov tshuaj tua kab mob thiab kev txhawb nqa, kom ntseeg tau tias tsis muaj CRS hnyav. Cov txheej txheem xws li kev ntws dej hauv plab thiab kev hloov kho stent tau ua tiav nrog kev ua tib zoo, ua rau cov tsos mob zoo dua thiab cov txiaj ntsig zoo tom qab kev kho mob.

BIOOCUS sawv tawm rau nws cov kev pabcuam zoo tshaj plaws thiab cov khoom tshiab. Peb txoj kev kho mob CAR-T, tsom mus rau CLDN18.2, muab kev tawm tsam rau cov hlwb qog noj ntshav, feem ntau ua tiav qhov twg cov kev kho mob ib txwm ua tsis tiav. Cov kev pabcuam rau tus neeg mob zoo tshaj plaws hauv kev sib koom tes thoob ntiaj teb, muab kev nkag siab txog kab lis kev cai, thiab muab kev saib xyuas tag nrho, txhua yam tsis muaj kev ntxhov siab ntxiv. Thirandas txaus siab rau cov neeg ua haujlwm uas muaj kev khuv leej thiab cov txheej txheem ua haujlwm zoo uas tau hloov qhov kev paub tsis zoo mus rau hauv kev cia siab.