He kanaka kūpaʻa mai India mai e hakakā ana i ka maʻi ʻōpū

Aia kekahi kanaka kūpaʻa i kapa ʻia ʻo Thirandas Shiva Prasad. He 32 ona makahiki, a no India mai ʻo ia. No ke aha mākou e hōʻike ai i kona kūpaʻa? Eia kāna moʻolelo kupaianaha.

Ua ʻike ʻia ʻo Thirandas me ke kanesa ʻōpū i ka makahiki 2023, me ka ʻeha o ka ʻōpū a ua hōʻoia ʻia he haʻahaʻa haʻahaʻa o ka signet ring cell adenocarcinoma. Ua hana ʻo ia i ka chemotherapy neoadjuvant me ka regimen FLOT, a ukali ʻia e ke ʻoki ʻana me ka gastrectomy subtotal. ʻOiai nā lāʻau lapaʻau postoperative, ua hoʻi hou ke kanesa me nā metastases i ka pelvis, e hoʻoulu ana i nā pilikia e like me ka hydronephrosis, abscesses, a me nā mea pale. Ua hoʻomanawanui ʻo ia i nā hana he nui, me ka dialysis, stenting, a me ka chemo hou me nab-paclitaxel, nivolumab, irinotecan, a me nā mea ʻē aʻe. I ka makahiki 2025, ua hōʻike nā scan PET-CT i ka holomua me ka hoʻonui ʻia o nā ʻeha ʻōpū a me nā ascites, e waiho ana iā ia i ka pono o nā koho hou.

I ka ʻimi ʻana i ka mālama ʻoi loa, ua huli ʻo Thirandas iā BIOOCUS. Ua hāʻawi kā mākou hui loea i kahi loiloi mua manuahi, e nānā ana i kāna mōʻaukala ākea a ke paipai nei i ka CLDN18.2 CAR-T cell therapy, i hana ʻia no ka hōʻike ʻana o kāna puʻupuʻu. Ma hope o ka hoʻomaʻamaʻa mua ʻana, ua hana maʻalahi ʻia ka hoʻokomo ʻana ma kā mākou hale hana holomua. ʻOiai nā pilikia mua e like me ke kuni a me ka maʻi hiki ke loaʻa, ua hoʻokele pono kā mākou hui multidisciplinary i nā hōʻailona me nā antibiotics a me ka mālama kākoʻo, e hōʻoiaʻiʻo ana ʻaʻohe CRS koʻikoʻi. Ua mālama pono ʻia nā kaʻina hana e like me ka hoʻokahe ʻana o ka ʻōpū a me nā hoʻoponopono stent, e alakaʻi ana i ka hōʻoluʻolu o nā hōʻailona a me nā hopena pathology maikaʻi ma hope o ka mālama ʻana.

ʻO BIOOCUS ke kū nei no kāna lawelawe kiʻekiʻe a me nā huahana hou. ʻO kā mākou lāʻau lapaʻau CAR-T, e kuhikuhi ana iā CLDN18.2, hāʻawi i kahi hoʻouka kaua i kuhikuhi ʻia i nā ʻōpū kanesa, e holomua pinepine ana i kahi e hāʻule ai nā lāʻau lapaʻau maʻamau. ʻOi aku ka maikaʻi o nā lawelawe maʻi i ka hoʻonohonoho ʻana i nā huakaʻi honua, e hāʻawi ana i ka ʻike moʻomeheu, a me ka hāʻawi ʻana i ka hahai piha, me ka ʻole o ke kaumaha keu. Mahalo ʻo Thirandas i nā limahana lokomaikaʻi a me nā kaʻina hana kūpono i hoʻololi i kahi ʻike weliweli i mea e manaʻolana ai.