FUCASO: ʻO ka lāʻau lapaʻau BCMA CAR-T kanaka piha me ka pono a me ka palekana i kūlike ʻole

Nā helu pane kiʻekiʻeʻO ka helu pane holoʻokoʻa (ORR) o 98.9% a me ka helu pane piha (CR) o 82.4%, ʻoi aku ke kiʻekiʻe ma mua o nā lāʻau lapaʻau ʻē aʻe i loaʻa.

Kala ʻana PaʻaUa hōʻike nā maʻi i mālama ʻia me FUCASO i kahi helu Progression-Free Survival (PFS) 12-mahina o 85.5%, e hōʻike ana i ke kala ʻana no ka wā lōʻihi a me ka hoʻomaikaʻi ʻana i ke ʻano o ke ola.

ʻIkepili PalekanaMe ka ≥3 grade Cytokine Release Syndrome (CRS) e kū nei i ka 1% wale nō o nā maʻi a ʻaʻohe hihia i hōʻike ʻia o ka ≥3 grade Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS), hāʻawi ʻo FUCASO i kahi koho lapaʻau palekana i hoʻohālikelike ʻia me nā lāʻau lapaʻau CAR-T ʻē aʻe.

Ka Pono o ke KumukūʻaiʻOi aku ka liʻiliʻi o ke kumukūʻai o ka mālama ʻana iā FUCASO ma mua o nā ʻano like i loaʻa ma ʻAmelika Hui Pū ʻIa, e lilo ana ia i koho kūpono no kahi ākea o nā maʻi.

Hōʻea HonuaUa hoʻokumu ʻo IASO BIO i kahi pūnaewele kikowaena lapaʻau piha ma Kina, hiki ke lawelawe i nā maʻi mai ka honua holoʻokoʻa me nā lawelawe i hoʻohui ʻia mai ke kūkākūkā ʻana a i ka mālama ma hope o ka mālama ʻana.

Ua loaʻa i ka mea maʻi mua i mālama ʻia me FUCASO ʻelima mau makahiki o ke ola ʻole ʻana mai ka maʻi kanesa, kahi hanana kupaianaha i hoʻohālikelike ʻia me ka median Progression-Free Survival (PFS) o 2.9 mau mahina wale nō me ka mālama maʻamau. Hōʻike kēia i ka hiki o FUCASO ke hoʻololi i ke ʻano lapaʻau no ka myeloma multiple.