FUCASO: Kurapa kweBCMA CAR-T kweVanhu Vakazara Nesimba Risina Kuenzana uye Kuchengetedzeka
ruzivo rwechigadzirwa
FUCASO, yakagadzirwa neNanjing IASO Biotechnology, mushonga weCAR-T wakagadzirwa zvakananga kunanga B-cell maturation antigen (BCMA). Mushonga uyu unoshamisa nekuda kwekushanda kwawo kwakanaka uye kuchengetedzeka, zvichipa tariro itsva kune varwere vane myeloma yakawanda inodzokera shure kana kuti isingadzoreki. Yakatenderwa neNational Medical Products Administration (NMPA) musi wa30 Chikumi, 2023, FUCASO yakatoratidza kubudirira kukuru mukushandiswa kwemishonga.
Mabhenefiti Akakosha eFUCASO
Mamiriyoni Ekupindura AkakwiraFUCASO ine Overall Response Rate (ORR) ye98.9% uye Complete Response (CR) rate ye82.4%, yakakwira zvakanyanya kupfuura mamwe marapirwo aripo.
Kuregererwa Kunogara: Varwere vakarapwa neFUCASO vakaratidza mwero wemwedzi gumi nemiviri weProgression-Free Survival (PFS) we85.5%, zvichiratidza kurerukirwa kwenguva refu uye kuvandudzika kwehupenyu.
Nhoroondo Yekuchengetedza: Nechirwere cheCytokine Release Syndrome (CRS) chegiredhi rechitatu (≥3 grade) chiri kuitika mu1% chete yevarwere uye pasina nyaya dzakataurwa dzechirwere cheImmune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) chegiredhi rechitatu (≥3 grade), FUCASO inopa nzira yakachengeteka yekurapa kana tichienzanisa nedzimwe nzira dzekurapa dzeCAR-T.
Kushanda Nemutengo Wakanaka: Kurapa kweFUCASO kunodhura zvishoma pane kurapwa kwakafanana kuripo muUnited States, zvichiita kuti ive sarudzo inoshanda kune varwere vakawanda.
Kusvika Pasi Pose: IASO BIO yakagadzira network yakazara yenzvimbo dzekurapa muChina, inokwanisa kushandira varwere vanobva kumativi ese enyika nemabasa akabatanidzwa kubva pakubvunzana kusvika pakutarisirwa mushure mekurapwa.
Kubudirira Kwekiriniki
Murwere wekutanga akarapwa neFUCASO awana makore mashanu ekurarama asina kenza, chiitiko chinoshamisa kana tichienzanisa neProgression-Free Survival (PFS) yemwedzi 2.9 chete nekurapwa kwakajairika. Izvi zvinoratidza kugona kweFUCASO kushandura mamiriro ekurapa kwemultiple myeloma.
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