Kukunda kwaMadhavan: Kukunda Brain Glioma neBioocus B7H3 CAR-T Therapy

Nhoroondo yeMurwere

Madhavan akaonekwa aine chirwere chegomarara remuuropi, bundu rinozivikanwa nekusapinda kwaro mumuviri uye kufambira mberi kwaro muropa. Ava nemakore 58, mushure mekunge kurapwa kwakajairika kunosanganisira kuvhiyiwa uye radiation yakundikana, akatsvaga Bioocus kuti awane dzimwe nzira dzepamusoro. Akaendeswa kuTianjin Tumor Hospital Konggang Hospital, akanyoresa muchirongwa chedu cheB7H3 CAR-T pasi penhamba yekurapa P001. B7H3 inoonekwa zvakanyanya pamasero egomarara, zvichiita kuti ive chinangwa chakakodzera chemasero eT akagadzirwa anopiwa kuburikidza necerebrospinal fluid (CSF) kurwisa bundu zvakananga.

Rwendo rweKurapwa

Kurapa kwaMadhavan kwaisanganisira kuisa masero eCAR-T emuviri muCSF, nekutarisa kuburikidza nekuongorora kweCSF kubva paZuva rechipiri (D2) kusvika paZuva rechipiri (D28).

• D2 (Nyamavhuvhu 8, 2025):Kuvapo kwakasimba kwekutanga neB7H3 CAR-T pa54.44% yemasero eCD3+ T.
• D4 (Nyamavhuvhu 11, 2025):52%, zvichiratidza mafambiro ekutanga.
• D7 (Nyamavhuvhu 14, 2025):Yakakwira kusvika pa59.51%.
• D10 (Nyamavhuvhu 17, 2025):12%.
• D14 (Nyamavhuvhu 21, 2025):19%.
• D21 (Nyamavhuvhu 28, 2025):Yakasvika pa89.69%, zvichiratidza kuwedzera kwakanyanya.
• D28 (Gunyana 6, 2025):Yakagadzikana pa13.58% yemasero eCD3+ T, ne11.90% muCD4+ uye 14.28% muzvikamu zveCD8+. Kazhinji, masero eCD3+ T akakunda pa95.34%, neCD8+ yakakwira (66.74%) ichiratidza simba guru rekuuraya utachiona.

Magirafu ekuwedzera anoratidza kugara kwenguva refu kweCAR-T asi kwakasimba, zvakakosha kuti bundu rirambe riripo muCNS.

Migumisiro Yakanaka

Kuwedzera kwakanyanya kweD21 kwakabatana nekuderera kwebundu paMRI, zvichikonzera kuti D28 iite zvishoma uye irambe ichivandudzika. Kuendeswa uku mukati memuviri kunoderedza migumisiro yakaipa mumuviri ukuwo kuchibatsira zvikuru pakurwisa maglioma, neruzivo rwedu ruchiratidza kuvandudzika kwehupenyu husina kufambira mberi. Madhavan akataura nezvezviratidzo zvinogoneka uye pasina chepfu yakanyanya muuropi.