Melanoma yeMetastatic-04

Murwere VaLi, murume ane makore makumi mana nemashanu ekuberekwa, vakatanga kurwadziwa mudumbu nguva dzose uye kudzikira uremu kutanga kwaKurume 2022. Kuongororwa kwakazotevera kuchipatara chemunharaunda kwakaita kuti vaongororwe muna Kubvumbi 2022 vaine chirwere chemetastatic melanoma. Pasinei nekuedza kurapwa kwakawanda kwakajairika, kusanganisira kuvhiyiwa, radiotherapy, uye chemotherapy, mamiriro avo ezvinhu akaramba achiipa, bundu richipararira kuchiropa nemapapu.

Mushure mekukundikana kwekuedza nekurapa kwakajairika, VaLi vakatsvaga dzimwe nzira dzekurapa muna Zvita 2022 mushure mekuwana mazano echiremba. Mushure mekubvunzana zvakanyanya uye kuferefeta, vakafunga kuedza mushonga mutsva wekudzivirira muviri unonzi Tumor-Infiltrating Lymphocyte (TILs) therapy.

Maitiro ekurapa kweTILs:

1. Kubviswa kwemuenzaniso webundu: Muna Ndira 2023, VaLi vakavhiyiwa kadiki kuti vabvise chikamu chebundu.

2. Kuwedzerwa kweLymphocyte: Murabhoritari, vaongorori vakabvisa Tumor-Infiltrating Lymphocytes (TILs) kubva musampuli yebundu rakabviswa. Malymphocyte aya akawedzerwa kakawanda mu vitro kuti asvike pahuwandu hwaidiwa pakurapwa.

3. Kugadzirira Chemotherapy: VaLi vasati vapinzwa masero eTIL, vakamborapwa chemotherapy kwenguva yakati rebei kuti vaderedze huwandu hwemalymphocytes aripo mumuviri wavo, zvichiita kuti pave nenzvimbo yemasero eTIL achangopinzwa.

4. Kuiswa kweTILs Cell Infusion: Muna Kurume 2023, masero eTILs akawedzerwa akaiswazve mumuviri waVaLi kuburikidza nekuiswa mutsinga.

5. Kurapa Kunotsigira: Kuti vawedzere kushanda kweTILs, VaLi vakabayiwawo majekiseni akawanda eInterleukin-2 (IL-2).

Mumwedzi yakatevera kurapwa, mamiriro aVaLi akavandudzika zvakanyanya. Maronda acho akadzikira zvakanyanya, uye maronda akapararira akaratidza zororo zvishoma. Kutevera muna Chikumi 2023 kwakaratidza kuti maronda muchiropa nemapapu akanga anyangarika zvachose. Hutano hwaVaLi hwakatanga kugadzikana zvishoma nezvishoma, huremu hwavo hwakadzoka, uye kurwadziwa kwavo mudumbu kwakadzikira.

"Pandakanzwa nezvechirwere changu, ndakanzwa sekunge nyika yese iri kuparara. Mushure mekurapwa kakawanda kusina kushanda, ndakanga ndava kuda kurasikirwa netariro. Nerombo rakanaka, ndakasangana neTILs therapy, iyo isina kungoponesa hupenyu hwangu chete asiwo yakadzoreredza tariro yangu yeramangwana. Ndinotenda vanachiremba vese nevatsvagiri vakandibatsira. Ndiwo mabasa enyu andipa mukana mutsva wehupenyu. Ndinovimba kuti therapy iyi inogona kubatsira varwere vakawanda vakaita seni kukunda kenza uye kugamuchira hupenyu hwakanaka zvakare."