Te mate pukupuku toto-04

I tīmata te tūroro a Mr. Li, he tāne 45-tau te pakeke, ki te pāngia e te mamae puku tonu me te hekenga taumaha i te tīmatanga o Poutū-te-rangi 2022. Nā ngā whakamātautau i muri mai i tētahi hōhipera o te rohe i kitea ai he mate melanoma metastatic i a ia i te Paenga-whāwhā 2022. Ahakoa te whakamātau i ētahi maimoatanga tuku iho, tae atu ki te pokanga, te radiotherapy, me te chemotherapy, i haere tonu te kino o tōna āhua, me te horapa o ngā pukupuku ki tōna ate me ōna pukahukahu.

Whai muri i ngā whakamātautau kore angitu me ngā rongoā paerewa, i rapu a Mr. Li i ngā huarahi maimoatanga rerekē i te Hakihea 2022 i runga i te tohutohu a te taote. Whai muri i te whakawhitiwhiti kōrero me te rangahau nui, ka whakatau ia ki te whakamātau i tētahi rongoā ārai mate auaha e kiia nei ko te rongoā Tumor-Infiltrating Lymphocyte (TILs).

Te Tukanga Whakaora TILs:

1. Te Tangohanga Tauira Puku: I te marama o Hānuere 2023, i mahia he pokanga iti ki a Mr. Li hei tango i tētahi wāhanga o te kiko pukupuku.

2. Te Whanuitanga o ngā Lymphocyte: I roto i te taiwhanga, i wehea e ngā kairangahau ngā Lymphocyte Puku-Whakauru (TIL) mai i te tauira pukupuku i tangohia. I whanuitia ēnei lymphocyte i roto i te vitro kia eke ki te rahinga e hiahiatia ana mō te maimoatanga.

3. Te Whakarite mō te Whakaora Matepukupuku: I mua i te werohanga o ngā pūtau TIL, i tukuna a Mr. Li ki te rongoā matepukupuku mō tētahi wā hei whakaiti i te maha o ngā lymphocytes kei roto i tōna tinana, kia wātea ai he wāhi mō ngā pūtau TIL hou kua werohangahia.

4. Te Werohanga Pūtau TIL: I te marama o Poutū-te-rangi 2023, i whakahokia mai ngā pūtau TIL kua whānui ki roto i te tinana o Mr. Li mā te werohanga ā-uaua.

5. Maimoatanga Tautoko: Hei whakarei ake i te mahi a ngā TIL, i whiwhi hoki a Mr. Li i ētahi werohanga o te Interleukin-2 (IL-2).

I ngā marama i muri i te maimoatanga, i tino pai ake te āhua o Mr. Li. I tino mimiti haere ngā pukupuku, ā, i kitea he oranga pakupaku o ngā whara kua horapa. I kitea i te arotakenga i te marama o Hune 2023 kua tata ngaro katoa ngā pukupuku i roto i te ate me ngā pukahukahu. I haere mārire te hauora whānui o Mr. Li ki te noho rite, i hoki mai tōna taumaha, ā, i memeha haere tōna mamae puku.

"I taku rongonga mō tōku āhua, i rite ki te mea e hinga ana te ao katoa. Whai muri i te wheako i ngā maimoatanga maha kāore i whai hua, tata ngaro taku tumanako. Waimarie, i tūtaki ahau ki te rongoā TILs, ehara i te mea i whakaora i tōku ora anake engari i whakahoki mai anō hoki i taku tumanako mō te heke mai. E mihi ana ahau ki ngā tākuta me ngā kairangahau katoa i āwhina i ahau. Nā ā koutou mahi i homai he oranga hou ki ahau. Ko taku tumanako ka taea e tēnei rongoā te āwhina i ngā tūroro pērā i ahau ki te wikitoria i te mate pukupuku me te awhi anō i te oranga hauora."