Te Wikitōria o Madhavan: Te Hinga i te Glioma Roro mā te Whakaora Bioocus B7H3 CAR-T

Papamuri o te Tūroro

I kitea a Madhavan he mate pukupuku roro, he pukupuku kino e mōhiotia ana mō tōna kaha ki te whakaeke me te kore e pai te putanga mai o te mate. I te 58 o ōna tau, i muri i te korenga o ngā maimoatanga tuku iho tae atu ki te pokanga me te irahiko, ka tahuri ia ki a Bioocus mō ngā kōwhiringa matatau. I tukuna ia ki te Hōhipera Tumor Tianjin Konggang, ā, i whakauru atu ia ki tā mātou kaupapa B7H3 CAR-T i raro i te nama maimoatanga P001. He nui te whakaputanga o te B7H3 i runga i ngā pūtau glioma, ā, he tino pai mō ngā pūtau T hangarau i tukuna mā te wai cerebrospinal (CSF) ki te whakaeke tika i te pukupuku.

Te Haerenga Maimoatanga

Ko te rongoā a Madhavan i uru atu ki te whakaurunga o ngā pūtau CAR-T autologous ki roto i te CSF, me te aroturukitanga mā roto i ngā tātaritanga CSF raupapa mai i te Rā 2 (D2) ki te Rā 28 (D28).

• D2 (8 o Ākuhata, 2025):He kaha te kitea tuatahi o te B7H3 CAR-T i te 54.44% o ngā pūtau CD3+ T.
• D4 (11 o Ākuhata, 2025):52%, e whakaata ana i ngā whanaketanga tōmua.
• D7 (14 o Ākuhata, 2025):I piki ake ki te 59.51%.
• D10 (17 o Ākuhata, 2025):12%.
• D14 (21 o Ākuhata, 2025):19%.
• D21 (28 o Ākuhata, 2025):I eke ki te 89.69%, e whakaatu ana i te whānui whakaharahara.
• D28 (6 o Hepetema, 2025):I whakapūmautia ki te 13.58% o ngā pūtau T CD3+, me te 11.90% i roto i te CD4+ me te 14.28% i roto i ngā rōpū iti CD8+. I te nuinga, ko ngā pūtau T CD3+ te nuinga i te 95.34%, me te CD8+ teitei (66.74%) e tohu ana i te kaha o te paitini pūtau.

I whakaatuhia e ngā kauwhata whānui te pumau o te CAR-T e piki haere ana engari he pakari i te nuinga, he mea nui mō te whakahaere tonu i te pukupuku i roto i te CNS.

Ngā Hua Tino Pai

I hono te whānui teitei o te D21 ki te whakahekenga o te pukupuku i runga i te MRI, ā, ka hua ake he urupare ā-wāhanga a D28 me te whakapai tonu. Mā tēnei tukunga ā-roto ka whakaitihia ngā pānga taha pūnaha me te whakanui ake i te whai huatanga ki ngā glioma, me ā mātou raraunga e whakaatu ana i te oranga ora kua pai ake me te kore e whanake haere. I kōrero a Madhavan he paitini te whakahaere, ā, kāore he paitini nui ki te roro.