Nasarar Madhavan: Kayar da Glioma na Brain da Bioocus B7H3 CAR-T Therapy

Bayanin Majiyyaci

An gano cewa Madhavan yana da ciwon kwakwalwa mai tsanani, wani ciwon daji da aka sani da ciwon da ke damun sa da kuma rashin kyawun hasashensa. Yana da shekaru 58, bayan da aka kasa yin amfani da magungunan gargajiya, ciki har da tiyata da radiation, ya koma Bioocus don neman hanyoyin ci gaba. An tura shi zuwa Asibitin Tumor na Tianjin da ke Konggang Hospital, ya shiga shirinmu na B7H3 CAR-T a ƙarƙashin lambar magani P001. B7H3 yana da matuƙar tasiri a cikin ƙwayoyin glioma, wanda hakan ya sa ya zama manufa mafi kyau ga ƙwayoyin T da aka ƙera waɗanda ake bayarwa ta hanyar ruwan cerebrospinal (CSF) don kai hari ga ciwon kai kai tsaye.

Tafiyar Maganin

Maganin Madhavan ya ƙunshi saka ƙwayoyin CAR-T masu kama da juna cikin CSF, tare da sa ido ta hanyar nazarin CSF daga Rana ta 2 (D2) zuwa Rana ta 28 (D28).

• D2 (8 ga Agusta, 2025):Ƙarfin samuwar farko mai ƙarfi tare da B7H3 CAR-T a kashi 54.44% na ƙwayoyin CD3+ T.
• D4 (11 ga Agusta, 2025):52%, wanda ke nuna yanayin farko.
• D7 (14 ga Agusta, 2025):An samu karuwar kashi 59.51%.
• D10 (17 ga Agusta, 2025):12%.
• D14 (21 ga Agusta, 2025):19%.
• D21 (28 ga Agusta, 2025):An samu kololuwar kashi 89.69%, wanda hakan ya nuna karuwar da ba a saba gani ba.
• D28 (Satumba 6, 2025):An daidaita shi a kashi 13.58% na ƙwayoyin CD3+ T, tare da kashi 11.90% a cikin CD4+ da kuma kashi 14.28% a cikin ƙananan CD8+. Gabaɗaya, ƙwayoyin CD3+ T sun mamaye kashi 95.34%, tare da babban CD8+ (66.74%) wanda ke nuna guba mai ƙarfi a cikin ƙwayoyin halitta.

Jadawalin faɗaɗawa sun nuna canjin yanayi amma gabaɗaya mai ƙarfi na juriyar CAR-T, wanda yake da mahimmanci don ci gaba da sarrafa ciwon daji a cikin CNS.

Sakamako Masu Kyau

Faɗaɗar da aka yi a kan D21 ta yi daidai da raguwar ciwon daji a kan MRI, wanda hakan ya haifar da wani ɓangare na amsawar D28 da ci gaba da ingantawa. Wannan isarwa ta cikin jiki yana rage tasirin da ke tattare da tsarin yayin da yake haɓaka inganci ga gliomas, tare da bayananmu da ke nuna ingantaccen rayuwa ba tare da ci gaba ba. Madhavan ya ba da rahoton alamun da za a iya sarrafawa kuma babu mummunan guba a cikin jijiyoyi.