Yaro yana fama da cutar sankarar jini mai tsanani (lymphoblastic leukemia)

Bayanin Majiyyaci na Asali

Wani namiji ɗan shekara 16 da aka gano yana da cutar sankarar lymphoblastic mai tsanani (B-ALL), wanda aka fara yi masa maganin chemotherapy, maganin CD19/22 CAR-T cell therapy, maganin salvation chemotherapy, da kuma dashen ƙwayoyin haploidical allogeneic hematopoietic stem cell (allo-HSCT) daga mai ba da gudummawa ga iyaye.

Yanayin Majinyaci Kafin A Yi Magani

Kafin allurar allo-HSCT, majiyyacin ya fuskanci saurin yaduwar ƙwayoyin jinin fari da kuma ci gaba da kamuwa da cuta duk da yawan shiga tsakani. Bayan allurar CD19/22 CAR-T a ranar 21 ga Afrilu, 2025 (jimillar ƙwayoyin CAR-T: 6.5×10^7), adadin ƙwayoyin CAR-T ya fara faɗaɗa zuwa 3.95×10^6/L a rana ta 7 amma ya ragu zuwa 0.82×10^6/L a rana ta 14, tare da ƙwayoyin fashewar jini na gefe suna ƙaruwa daga 28.6% zuwa 87.1%. Binciken ƙashi a ranar 15 ga Mayu, 2025, ya nuna raguwar yaduwar ƙwayoyin B marasa kyau 37.42% (wanda ke nuna CD34, ɓangaren CD38/CD22, rauni CD81/CD19/CD33, babu CD10/CD20/CD79b), yana tabbatar da babu sassauci. Ruwan kwakwalwa bai nuna ƙwayoyin halitta marasa kyau ba, amma cutar gaba ɗaya ba ta ragu ba.

Yanayin Majinyaci Bayan Jinya

Bayan allurar allo-HSCT a ranar 29-30 ga Mayu, 2025 (ƙwayoyin CD34+: 8.6×10^6/kg; ƙwayoyin mononuclear: 8×10^8/kg), majiyyacin ya sami nasarar sanya neutrophil a rana ta 11 da kuma sanya platelet a rana ta 18. A rana ta 28 (Yuni 27, 2025), ƙididdigar jini ta inganta sosai: haemoglobin 99 g/L (daga ƙananan matakan da suka gabata), fararen ƙwayoyin jini 11.73×10^9/L, neutrophils 9.81×10^9/L, da platelets 79×10^9/L. Siffar ƙashi ta nuna yawan ƙwayoyin halitta marasa asali, an tabbatar da cewa babu wani rashin daidaituwa, biopsy ya nuna ƙarancin yaduwa amma ana iya ganin ƙwayoyin trilineage ba tare da lymphocytes marasa girma ba, kuma STR chimerism ya kai 100%, wanda ya cimma cikakkiyar gafara (CR) tare da ƙarancin sauran cututtukan da suka rage (MRD-). A rana ta 49 (18 ga Yuli, 2025), ƙashin ƙashi ya ci gaba da aiki ba tare da ƙwayoyin halitta marasa kyau ba, yana ci gaba da riƙe CR da MRD-. An sami cutar dashen hanji mai sauƙi na mataki na 1 amma an magance ta da magunguna, wanda ya nuna ingantaccen iko da murmurewa daga cututtuka idan aka kwatanta da fashewar da ta ci gaba kafin dashen (daga 37.42% zuwa 0%) da rashin gafara.