Ib tug tub hluas uas muaj mob leukemia lymphoblastic loj heev

Cov Ntaub Ntawv Tseem Ceeb ntawm Tus Neeg Mob

Ib tug txiv neej hnub nyoog 16 xyoo uas tau kuaj pom tias muaj mob leukemia lymphoblastic (B-ALL), uas tau txais kev kho mob chemotherapy thawj zaug, kev kho mob CD19/22 CAR-T cell, kev kho mob salvage chemotherapy, thiab tom qab ntawd haploidentical allogeneic hematopoietic stem cell transplantation (allo-HSCT) los ntawm niam txiv pub dawb.

Tus Neeg Mob Qhov Xwm Txheej Ua Ntej Kev Kho Mob

Ua ntej allo-HSCT, tus neeg mob tau muaj cov qe ntshav dawb sai sai thiab muaj kab mob tas li txawm tias muaj ntau yam kev kho mob los xij. Tom qab CD19/22 CAR-T infusion rau lub Plaub Hlis 21, 2025 (tag nrho cov qe CAR-T: 6.5 × 10 ^ 7), CAR-T cell suav thaum pib nthuav dav mus rau 3.95 × 10 ^ 6 / L los ntawm hnub 7 tab sis poob qis mus rau 0.82 × 10 ^ 6 / L los ntawm hnub 14, nrog rau cov qe ntshav tawg peripheral nce ntawm 28.6% mus rau 87.1%. Kev kuaj pob txha rau lub Tsib Hlis 15, 2025, qhia tau tias muaj kev loj hlob tsawg heev nrog 37.42% tsis zoo B lymphoblasts (qhia CD34, ib nrab CD38 / CD22, tsis muaj zog CD81 / CD19 / CD33, tsis muaj CD10 / CD20 / CD79b), lees paub tias tsis muaj kev zam txim. Cov kua dej cerebrospinal tsis qhia cov qe ntshav tsis zoo, tab sis tag nrho cov kab mob tseem tsis tau zoo.

Tus Neeg Mob Tom Qab Kev Kho Mob

Tom qab allo-HSCT thaum lub Tsib Hlis 29-30, 2025 (CD34+ hlwb: 8.6 × 10 ^ 6 / kg; mononuclear hlwb: 8 × 10 ^ 8 / kg), tus neeg mob tau ua tiav neutrophil engraftment los ntawm hnub 11 thiab platelet engraftment los ntawm hnub 18. Los ntawm hnub 28 (Lub Rau Hli 27, 2025), cov ntshav suav tau zoo dua qub: hemoglobin 99 g / L (los ntawm cov qib qis ua ntej), cov qe ntshav dawb 11.73 × 10 ^ 9 / L, neutrophils 9.81 × 10 ^ 9 / L, thiab platelets 79 × 10 ^ 9 / L. Cov pob txha pob txha morphology qhia txog kev loj hlob nquag tsis muaj cov hlwb primitive txawv txav, flow cytometry lees paub tias tsis muaj qhov txawv txav, biopsy qhia txog kev loj hlob tsawg tab sis pom cov hlwb trilineage tsis muaj immature lymphocytes, thiab STR chimerism tau mus txog 100%, ua tiav kev zam txim tag nrho (CR) nrog qhov tsawg kawg nkaus seem kab mob tsis zoo (MRD-). Txog hnub 49 (Lub Xya Hli 18, 2025), cov pob txha tseem ua haujlwm tsis muaj cov hlwb txawv txav, tseem muaj CR thiab MRD-. Muaj tus kab mob qog nqaij hlav qib 1 me me uas tsis tshua muaj tab sis tau tswj hwm nrog cov tshuaj, qhia tau tias muaj kev tswj hwm kab mob zoo thiab rov zoo piv rau cov kab mob qog nqaij hlav ua ntej hloov pauv (los ntawm 37.42% mus rau 0%) thiab tsis muaj kev zam txim.