Junaid ---- Mob Ntshav Qab Zib B-lymphocytic Mob Ntshav Qab Zib (B-ALL)

Kev sim tshuaj CAR-T txuas kev hloov pob txha ua rau cov neeg mob B-ALL uas tsis kho tau kab mob tsis muaj kab mob ntawm BIOOCUS Medical Group.

Tsib xyoos dhau los, Junaid yog ib tug tub ntxhais kawm ntawv ntawm Pakistan Medical University, uas muaj lub siab xav ua ib tug kws kho mob. Tab sis thaum lub Tsib Hlis 2014, nws tau kuaj pom tias muaj mob qog ntshav B-lymphocytic thiab yuav tsum tso tseg nws txoj kev kawm.

Nws tau txais kev kho mob hauv zos tau ntau tshaj ob xyoos. Thaum Lub Ib Hlis 2018, nws tau mob pob txha thoob plaws lub cev dua thiab kev kuaj pob txha qhia tau tias nws tau rov qab mob dua. Tom qab kev kho mob chemotherapy zaum ob ntawm tsev kho mob hauv zos, nws tsis tuaj yeem ua tiav kev zam txim thiab tus kab mob tau nce qib. Los ntawm kev tshawb nrhiav hauv internet thiab cov lus qhia ntawm lwm tus neeg mob, lawv tau txiav txim siab tuaj rau peb lub chaw CGT rau kev sim tshuaj CART thiab BMT theem siab tshaj plaws.

Thaum Lub Peb Hlis 26, 2018, Junaid thiab nws tsev neeg tau tuaj rau Suav teb thiab tau raug xa mus rau chav kho mob ntshav dav dav. Dr. tau ua qhov kev ntsuam xyuas tag nrho ntawm Junaid. Cov ntawv ceeb toom qhia tau hais tias qhov hnyav ntawm cov pob txha tawg yog siab txog 69% thiab nws muaj kab mob ntsws fungal. Tom qab kev kho mob zoo, tus neeg mob nyob rau hauv qhov xwm txheej ruaj khov. Thaum Lub Plaub Hlis 24, 2018, Junaid tau rov ua dua nrog ob lub hlwb CD19 & CD22 CAR-T. Tom qab ob lub lis piam, cov lej ntawm cov hlwb pob txha tawg yog 0. Tsev neeg Junaid luag nyav rov qab los. Junaid yuav tsum tau kuaj BMT kom tsis muaj kab mob.

Thaum Lub Rau Hli 25, 2018, tus kws kho mob ntawm chav BMT tau ua BMT rau Junaid. Tus neeg pub rau Junaid yog nws tus kwv yau. thaum Lub Xya Hli 6, tus neeg pub peripheral stem cell tau muab rov qab rau hauv Junaid, tom qab 17 hnub kev hloov ntshav dawb tau ua tiav thiab nws tau tsiv tawm ntawm chav laminar flow. Tom qab 24 hnub, nws hom pob txha pob txha sib xws nrog tus neeg pub hom pob txha pob txha. Kev tshuaj xyuas daim ntawv qhia txog cov pob txha pob txha seem tsis zoo, tsis muaj teeb meem thaum ntxov ntsig txog kev hloov ntshav. Thaum Lub Yim Hli 6, 2018, Junaid tau tawm hauv tsev kho mob thiab pib saib xyuas tus neeg mob sab nraud.

Lub koom haum ntshav Suav teb yog qhov kev txhawb nqa zoo rau tus neeg mob Junaid yog hom ntshav RH tsis zoo, uas yog hom ntshav tsawg. Nws tau txais "Lang Fang rare blood type alliance" pub ntshav dawb ntau zaus thaum nws nyob hauv tsev kho mob. Nws yeej tsis zoo li tsis muaj ntshav txaus rau nws, Junaid thiab nws tsev neeg ua tsaug rau lub chaw pabcuam thoob ntiaj teb rau kev ua txhua yam no rau Junaid. Lub sijhawm ntawd, cov neeg ua haujlwm ntawm lub chaw pabcuam thoob ntiaj teb tau nrog Junaid thiab nws tsev neeg txij thaum lawv tuaj txog txog tam sim no, tau muab kev txhawb nqa rau lawv txhua tus thiab pab tsev neeg kov yeej qhov teeb meem lus.

Kev sim tshuaj CAR-T txuas BMT kom tsim tau lwm qhov txuj ci tseem ceeb. Junaid yog tus neeg mob thib ob uas rov qab mob thiab tsis kho tau kab mob B-lymphocytic leukaemia los ntawm Pakistan kom tau txais kev kho mob CAR-T Bridge BMT. Junaid txoj kev tawm hauv tsev kho mob zoo dua ib zaug ntxiv yog qhov lees paub thoob ntiaj teb ntawm peb lub tsev kho mob cov thev naus laus zis siab heev ntawm kev hloov pauv CAR-T.