ʻO Junaid----ʻO ka maʻi leukemia lymphocytic B koʻikoʻi (B-ALL)

ʻO ka hoʻoili ʻana o ka iwi iwi alahaka i ka hoʻokolohua lapaʻau CAR-T e hoʻolilo i ka poʻe maʻi B-ALL paʻakikī i ka maʻi me ka ʻole o ka maʻi ma BIOOCUS Medical Group.

ʻElima mau makahiki i hala aku nei, he haumāna ʻo Junaid ma ke Kulanui Lapaʻau ʻo Pakistan, piha i ka makemake e lilo i kauka. Akā i Mei 2014, ua ʻike ʻia ʻo ia he maʻi leukemia B-lymphocytic acute a pono ʻo ia e haʻalele i kāna mau haʻawina.

Ua mālama ʻia ʻo ia ma kahi kūloko no ʻelua mau makahiki. I Ianuali 2018, ua loaʻa hou iā ia ka ʻeha iwi systemic a ua hōʻike ʻia kahi hoʻokolokolo iwi iwi ua hoʻi hou ʻo ia. Ma hope o ka lua o ka papa o ka chemotherapy ma ka haukapila kūloko, ʻaʻole hiki iā ia ke hoʻokō i ke kala ʻana a ua holomua ka maʻi. Ma o ka ʻimi pūnaewele a me ka ʻōlelo aʻoaʻo a nā poʻe maʻi ʻē aʻe, ua hoʻoholo lākou e hele mai i kā mākou kikowaena CGT no ka hoʻokolohua lapaʻau CART kiʻekiʻe a me BMT.

Ma ka lā 26 Malaki 2018, ua hele mai ʻo Junaid a me kona ʻohana i Kina a ua hoʻokomo ʻia i ka ʻoihana hematology laulā. Ua hana ʻo Kauka i kahi loiloi piha o Junaid. Ua hōʻike nā hōʻike ua kiʻekiʻe ka ukana pahū iwi i ka 69% a ua loaʻa iā ia nā maʻi fungal pulmonary. Ma hope o ka mālama pono ʻana, ua kūpaʻa ke kūlana o ka mea maʻi. Ma ka lā 24 ʻApelila 2018, ua hoʻokomo hou ʻia ʻo Junaid me nā pūnaewele CD19 & CD22 CAR-T pālua. Ma hope o ʻelua pule, ua 0 ka helu o nā pūnaewele pahū iwi. Ua hoʻi hou nā minoʻaka i ka ʻohana o Junaid. E hana ʻia ʻo Junaid ma BMT i mea e maʻi ʻole ai.

Ma ka lā 25 o Iune 2018, ua hana ke Kauka o ka ʻOihana BMT i ka BMT hoahānau no Junaid. ʻO ka mea hāʻawi no Junaid kona kaikaina. Ma ka lā 6 o Iulai, ua hoʻokomo hou ʻia ke kelepona kumu peripheral o ka mea hāʻawi i loko o Junaid, ma hope o 17 mau lā ua pau ke kāpili ʻana o nā kelepona koko keʻokeʻo a ua neʻe ʻo ia i waho o ka lumi hoʻopaʻa laminar. Ma hope o 24 mau lā, ua kūlike loa ke ʻano o kona iwi iwi me ke ʻano o ka iwi iwi o ka mea hāʻawi. ʻAʻole maikaʻi ka loiloi ʻana i ka hōʻike koena o ka iwi iwi, me ka ʻole o nā pilikia mua e pili ana i ke kāpili ʻana. Ma ka lā 6 o ʻAukake 2018, ua hoʻokuʻu ʻia ʻo Junaid mai ka haukapila a hoʻomaka i ka nānā ʻana ma waho.

ʻO ka hui koko Kina ke kākoʻo paʻa o ka mea maʻi. ʻO Junaid ke ʻano koko RH maikaʻi ʻole, he ʻano koko kakaʻikahi. Ua ʻae ʻo ia i ka hāʻawi koko manuahi "Lang Fang rare blood type alliance" no nā manawa he nui i kona wā ma ka haukapila. ʻAʻole like me ka nele o ke koko iā ia, mahalo nui ʻo Junaid a me kona ʻohana i ke kikowaena honua no ka hana ʻana i kēia mau mea a pau no Junaid. I kēia manawa, ua hele pū nā limahana o ke kikowaena honua me Junaid a me kona ʻohana mai ko lākou pae ʻana a hiki i kēia manawa, hāʻawi iā lākou i ke kākoʻo ola a kōkua i ka ʻohana e lanakila i ka pale ʻōlelo.

Hoʻopili ka hoʻokolohua lapaʻau CAR-T iā BMT e hana i kahi hana mana ʻē aʻe. ʻO Junaid ka lua o ka mea maʻi leukemia B-lymphocytic acute relapsed a refractory mai Pakistan e loaʻa i ka lāʻau lapaʻau CAR-T Bridge BMT. ʻO ka hoʻokuʻu kūleʻa ʻana o Junaid mai ka haukapila e hōʻailona hou ana i ka ʻike honua o ka ʻenehana holomua o kā mākou haukapila o ka hoʻoili ʻana i ke alahaka CAR-T.