ʻO ka maʻi leukemia lymphoblastic koʻikoʻi (B-ALL)

Ua loaʻa i kahi maʻi 61 makahiki mai Suria mai e hakakā nei i ka acute lymphoblastic leukemia (ALL) kahi manawa hou i ke ola ma o ka lāʻau lapaʻau CAR-T, ma ka laulima ʻana me BIOOCUS, nāna i hāʻawi i ka huahana CAR-T i hoʻohana ʻia i kāna lāʻau lapaʻau.

Ua kaʻana like ʻo Mohammed, ke keiki a ka mea maʻi, i ka huakaʻi lōʻihi o kona makuahine me ka leukemia. Ua ʻike ʻia ʻo ia me ALL i ka makahiki 2012, ua pane mua kona makuahine i ka chemotherapy a ua hoʻomaha ʻia no ʻelima mau makahiki. ʻO ka mea pōʻino, ua hoʻi hou kona maʻi i ka makahiki 2018, e alakaʻi ana i kahi pōʻai ʻē aʻe o ka chemotherapy a me kahi hoʻoili iwi allogeneic. Eia naʻe, ʻeono mahina ma hope o ke kāpili ʻana, ua hoʻi hou ka leukemia, a ʻaʻole hiki ke koho hou ʻia ka chemotherapy. Ua ʻimi ka ʻohana i nā lāʻau lapaʻau ʻē aʻe akā ua kū i nā palena ma Suria, kahi i loaʻa ʻole ai nā lāʻau lapaʻau holomua e like me CAR-T.

Ma hope o ka noiʻi nui ʻana, ua ʻike ʻo Mohammed aia ʻo Kina ma ke alo o ka lāʻau lapaʻau CAR-T a ua mālama kēlā haukapila ma mua o 500 mau maʻi me nā helu holomua kiʻekiʻe, ʻoi aku hoʻi no ALL, me ka haʻaheo ʻana i nā helu kala ma luna o 90%. Hoʻoikaika ʻia e kēia mau helu helu, ua hoʻonohonoho ʻo Mohammed i kona makuahine e loaʻa ka lāʻau lapaʻau ma ka Halemai ʻo Lu Daopei.

I ka hōʻea ʻana i Kina, ua ʻike nā kauka he nui loa ka ukana o ka puʻupuʻu o ka mea maʻi he 80% i loko o kona iwi iwi, e hoʻokaʻawale ana iā ia he mea maʻi pilikia kiʻekiʻe. ʻOiai kēia mau pilikia, ua hoʻomaka ka hui lapaʻau ma ka haukapila, ʻo Kauka Song, i ka lāʻau lapaʻau me ka hoʻohana ʻana i nā pūnaewele CAR-T i hāʻawi ʻia e BIOOCUS, ka mea loea i ka hāʻawi ʻana i nā huahana CAR-T holomua i nā haukapila ma ka honua holoʻokoʻa.

Ma hope o 15 mau lā wale nō o ka lāʻau lapaʻau CAR-T, i hui pū ʻia me ka chemotherapy conditioning, ua hoʻokō ka mea maʻi i ke kala piha ʻana. Ua hōʻike kāna mau hopena hoʻāʻo he MRD-negative, ʻo ia hoʻi, ʻaʻohe mau cell leukemia i ʻike ʻia i koe. Ua hōʻike ʻo Mohammed i ka mahalo nui no ka hopena, me ka ʻōlelo ʻana, "He hana mana ia. ʻAʻole e hāʻawi ka Chemotherapy a i ʻole kekahi immunotherapy ʻē aʻe i ka hopena like. Ua hoʻopakele ka lāʻau CAR-T i ke ola o koʻu makuahine."

Ua hoʻomaikaʻi pū ʻo ia i ka hui ma BIOOCUS Medical group me ka ʻōlelo ʻana, "He akamai loa a makaʻala nā kauka a me nā limahana, ʻoiai ka poʻe ma ke Kikowaena Honua. ʻAʻole lākou i hāʻawi wale i ka mālama olakino kiʻekiʻe akā i ke kākoʻo naʻau ma o kēia huakaʻi paʻakikī."

Hōʻike kēia hihia i ka mana o ka lāʻau lapaʻau CAR-T i ka mālama ʻana i nā maʻi ALL pilikia kiʻekiʻe, ʻoiai ka poʻe i kūleʻa ʻole nā ​​​​lāʻau kuʻuna. Me BIOOCUS ma ke ʻano he hoa hilinaʻi i ka hāʻawi ʻana i nā huahana CAR-T kiʻekiʻe loa, ke hoʻomau nei ka haukapila i ke alakaʻi i ka hāʻawi ʻana i nā lāʻau lapaʻau e hoʻōla ola a me ka hoʻolaha ʻana i ka lāʻau lapaʻau maʻi kanesa.

No nā poʻe maʻi e hakakā nei me ALL, hāʻawi ka lāʻau lapaʻau CAR-T i ka manaʻolana hou, ʻoiai ma nā hihia paʻakikī loa. Ke kūpaʻa nei ka Halemai ʻo Lu Daopei i ka hāʻawi ʻana i nā lāʻau lapaʻau hou a me ka hoʻomaikaʻi ʻana i nā hopena no nā poʻe maʻi me nā maʻi ʻaʻai koko.