I-Acute Lymphoblastic Leukemia (B-ALL)

Isigulana esineminyaka engama-61 ubudala esivela eSyria esilwa ne-acute lymphoblastic leukemia (ALL) sifumene ithuba elitsha lokuphila ngonyango lwe-CAR-T, ngokubambisana ne-BIOOCUS, eyanikezela ngemveliso ye-CAR-T esetyenziswa kunyango lwaso.

UMohammed, unyana wesigulana, wabelane ngohambo olude lukanina olune-leukemia. Efunyaniswe ene-ALL ngo-2012, unina waqala wasabela kwi-chemotherapy waza waphulukana nempilo yakhe kangangeminyaka emihlanu. Ngelishwa, isifo sakhe saphinda sabuya ngo-2018, nto leyo eyakhokelela kolunye umjikelo we-chemotherapy kunye nokufakelwa kwe-allogeneic bone marrow. Nangona kunjalo, emva kweenyanga ezintandathu emva kokufakelwa, i-leukemia yabuya kwakhona, kwaye i-chemotherapy eyongezelelweyo yayingasekho ndlela. Usapho lufune ezinye iindlela zonyango kodwa lwajongana nemida eSyria, apho unyango oluphambili olufana ne-CAR-T lwalungafumaneki khona.

Emva kophando olunzulu, uMohammed wafumanisa ukuba iTshayina yayiphambili kunyango lwe-CAR-T kwaye isibhedlele sasinyange izigulane ezingaphezu kwama-500 ngamanqanaba aphezulu empumelelo, ingakumbi kwi-ALL, enamazinga okuxolelwa angaphezulu kwama-90%. Ekhuthazwa zezi zibalo, uMohammed walungiselela ukuba umama wakhe afumane unyango kwiSibhedlele saseLu Daopei.

Bakufika eTshayina, oogqirha bafumanise ukuba isigulana sinomthwalo omkhulu kakhulu we-80% kwithambo laso, nto leyo eyasibeka kwisigulana esisengozini enkulu. Nangona le mingeni injalo, iqela lezonyango esibhedlele, uGqr. Song, laqalisa unyango olusebenzisa iiseli ze-CAR-T ezibonelelwa yi-BIOOCUS, egxile ekuhambiseni iimveliso ze-CAR-T ezisemgangathweni kwizibhedlele kwihlabathi liphela.

Emva kweentsuku ezili-15 kuphela zonyango lwe-CAR-T, kunye nonyango lwe-chemotherapy, isigulana safumana ukuphumla okupheleleyo. Iziphumo zovavanyo lwakhe zabonisa ukuba i-MRD ayinayo, nto leyo ethetha ukuba akukho ziseli ze-leukemia ezifunyenweyo eziseleyo. UMohammed ubonakalise umbulelo omkhulu ngesiphumo, esithi, "Ngummangaliso. I-Chemotherapy okanye naluphi na olunye unyango lwe-immunotherapy ngelungazange luzise iziphumo ezifanayo. Unyango lwe-CAR-T lusindise ubomi bukamama."

Ukwancome iqela le-BIOOCUS Medical group esithi, "Oogqirha nabasebenzi, ingakumbi abo base-International Center, babenezakhono ezibalaseleyo kwaye benononophelo. Abazange banike unyango oluphezulu kuphela kodwa banike nenkxaso yeemvakalelo kulo lonke olu hambo lunzima."

Eli tyala libonisa amandla onyango lwe-CAR-T ekunyangeni BONKE abaguli abasengozini enkulu, ingakumbi abo unyango lwendabuko luye lwasilela kubo. Njengoko i-BIOOCUS iliqabane elithembekileyo ekuboneleleni ngeemveliso ze-CAR-T ezisemgangathweni, isibhedlele siyaqhubeka nokukhokela ekunikezeni unyango olusindisa ubomi kunye nokuphucula unyango lomhlaza.

Kwizigulane ezilwa ne-ALL, unyango lwe-CAR-T lunika ithemba elitsha, nokuba kwiimeko ezinzima kakhulu. Isibhedlele saseLu Daopei sisazimisele ukubonelela ngonyango olutsha nokuphucula iziphumo zezigulane ezinomhlaza wegazi.