I-Junaid----I-Acute B-lymphocytic Leukemia (B-YONKE)

Ukufakelwa kwe-CAR-T clinical trial bridge bone marrow kwenza ukuba isifo se-B-ALL esingenakuphikiswa kwi-BIOOCUS Medical Group singabikho.

Kwiminyaka emihlanu eyadlulayo, uJunaid wayengumfundi kwiYunivesithi yezonyango yasePakistan, ezele yiminqweno yokuba ngugqirha. Kodwa ngoMeyi ka-2014, wafunyaniswa ukuba une-B-lymphocytic leukaemia ebukhali kwaye kwafuneka ayeke izifundo zakhe.

Unyangwe apha ekhaya kangangeminyaka engaphezu kwemibini. NgoJanuwari 2018, waphinda wafumana iintlungu zamathambo kwaye uvavanyo lomongo lwabonisa ukuba ubuyele esiqhelweni. Emva kwekhosi yesibini ye-chemotherapy kwisibhedlele sasekuhlaleni, akazange akwazi ukufumana ukuphumla kwaye isifo saqhubeka. Ngokukhangela kwi-intanethi kunye neengcebiso zabanye abaguli, bagqiba ekubeni beze kwiziko lethu le-CGT ukuze bafumane uvavanyo lweklinikhi lwe-CART oluphezulu kunye ne-BMT.

Ngomhla wama-26 kuMatshi 2018, uJunaid nosapho lwakhe beza eTshayina baza bangeniswa kwicandelo le-hematology jikelele. UGqr wenza uvavanyo olupheleleyo lukaJunaid. Iingxelo zibonise ukuba umthwalo wokuqhuma komongo wethambo wawufikelela kwi-69% kwaye wayenosulelo lwemiphunga yemiphunga. Emva konyango olucokisekileyo, isigulana sasikwimeko ezinzileyo. Ngomhla wama-24 ku-Epreli 2018, uJunaid waphinda wafakwa iiseli ezimbini ze-CD19 kunye ne-CD22 CAR-T. Emva kweeveki ezimbini, inani leeseli zokuqhuma komongo wethambo laliyi-0. Uncumo lwabuyela kusapho lukaJunaid. UJunaid wayeza kuvavanywa kwi-BMT ukuze angabi nasifo.

Ngomhla wama-25 kuJuni 2018, uGqirha weSebe le-BMT wenze i-BMT yomntakwabo uJunaid. Umnikeli kaJunaid ngumntakwabo omncinci. Ngomhla wesi-6 kuJulayi, i-peripheral stem cell yomnikeli yabuyiselwa kuJunaid, emva kweentsuku ezili-17 ukufakelwa kweseli emhlophe yegazi kwagqitywa waza waphuma kwi-laminar flow ward. Emva kweentsuku ezingama-24, uhlobo lwakhe lomongo luhambelana ngokupheleleyo nohlobo lomongo wethambo lomnikeli. Uphononongo lwengxelo eseleyo yomongo wethambo alunangqondo, akukho ngxaki ziphambili ezinxulumene nokufakelwa kweseli. Ngomhla wesi-6 ku-Agasti 2018, uJunaid waphuma esibhedlele waza waqalisa ukulandelwa kwezigulane zangaphandle.

Umbutho wegazi waseTshayina luxhasa kakhulu isigulana. UJunaid une-RH negative blood type, oluluhlobo lwegazi olungaqhelekanga. Wamkela umnikelo wegazi wasimahla "uLang Fang rare blood type alliance" amaxesha amaninzi ngexesha lokulaliswa kwakhe esibhedlele. Akubonakali ngathi kukho ukunqongophala kwegazi kuye, uJunaid nosapho lwakhe bayayixabisa kakhulu i-international center ngokwenza konke oku kuJunaid. Okwangoku, abasebenzi beziko lehlabathi bahamba noJunaid nosapho lwakhe ukususela ekufikeni kwabo ukuza kuthi ga ngoku, babanika inkxaso yobomi bonke kwaye banceda usapho ukuba loyise umqobo wolwimi.

Uvavanyo lweklinikhi lwe-CAR-T ludibanisa i-BMT ukuze yenze omnye ummangaliso. UJunaid sisigulana sesibini esine-B-lymphocytic leukaemia esibuyela umva nesinganyangekiyo esivela ePakistan esifumene unyango lwe-CAR-T Bridge BMT. Ukukhululwa ngempumelelo kukaJunaid esibhedlele kwakhona kubonisa ukuqatshelwa kwihlabathi liphela kobuchwepheshe obuphambili besibhedlele sethu bokufakelwa kwebhulorho ye-CAR-T.