Junaid----Acute B-lymphocytic Leukemia (B-ALL)

Kusamutsa mafupa a m'mayeso a CAR-T mlatho wa m'mafupa kwapangitsa kuti odwala matenda a B-ALL omwe sachira ku BIOOCUS Medical Group asakhale ndi matenda.

Zaka zisanu zapitazo, Junaid anali wophunzira ku Pakistan Medical University, wodzaza ndi chikhumbo chofuna kukhala dokotala. Koma mu Meyi 2014, adapezeka ndi khansa ya m'magazi ya B-lymphocytic ndipo adayenera kusiya maphunziro ake.

Analandira chithandizo chapafupi kwa zaka zoposa ziwiri. Mu Januwale 2018, anayambanso kupweteka kwa mafupa ndipo kufufuza kwa mafupa kunasonyeza kuti anabwereranso. Pambuyo pa chithandizo chachiwiri cha chemotherapy kuchipatala chapafupi, sanathe kupeza mpumulo ndipo matendawa anapitirira. Kudzera mu kufufuza pa intaneti ndi malangizo a odwala ena, adaganiza zobwera ku chipatala chathu cha CGT kuti akalandire mayeso apamwamba a CART ndi BMT.

Pa 26 Marichi 2018, Junaid ndi banja lake anabwera ku China ndipo analowetsedwa mu dipatimenti yoona za magazi. Dokotala adachita kafukufuku wathunthu wa Junaid. Malipotiwo adawonetsa kuti kuchuluka kwa kuphulika kwa mafupa kunali kokwera kufika pa 69% ndipo anali ndi matenda a bowa m'mapapo. Atalandira chithandizo mosamala, wodwalayo anali bwino. Pa 24 Epulo 2018, Junaid adapatsidwanso maselo awiri a CD19 ndi CD22 CAR-T. Patatha milungu iwiri, kuchuluka kwa maselo a kuphulika kwa mafupa kunali 0. Kumwetulira kunabwerera m'manja mwa banja la Junaid. Junaid anali kuchitidwa opaleshoni ya BMT kuti asakhale ndi matenda.

Pa 25 June 2018, dokotala wa dipatimenti ya BMT adamupatsa Junaid BMT mchimwene wake. Wopereka Junaid ndi mng'ono wake. Pa 6 July, selo loyambira la wopereka linabwezeretsedwanso ku Junaid, patatha masiku 17, kumuika maselo oyera a magazi kunatha ndipo anasamuka kuchoka mu chipinda choyezera madzi. Patatha masiku 24, mtundu wa mafuta ake a m'mafupa ukufanana ndi mtundu wa mafuta a m'mafupa a woperekayo. Kuwunikanso lipoti lotsala la mafuta a m'mafupa ndi loipa, ndipo palibe mavuto oyambirira okhudzana ndi kumuika. Pa 6 August 2018, Junaid anatulutsidwa kuchipatala ndipo anayamba kutsatira odwala akunja.

Bungwe la magazi la ku China ndi lothandiza kwambiri kwa wodwala. Junaid ali ndi mtundu wa magazi wopanda RH, womwe ndi mtundu wa magazi wosowa. Analandira "Lang Fang rare blood type alliance" kwaulere nthawi zambiri pamene anali kuchipatala. Kwa iye sizikuwoneka ngati kusowa kwa magazi, Junaid ndi banja lake amayamikira kwambiri bungwe lapadziko lonse lapansi chifukwa chochita zonsezi kwa Junaid. Pakadali pano, ogwira ntchito ku bungwe lapadziko lonse lapansi adatsagana ndi Junaid ndi banja lake kuyambira pomwe adafika mpaka pano, adawapatsa chithandizo cha moyo wonse ndikuthandiza banjali kuthana ndi vuto la chilankhulo.

Kuyesa kwa CAR-T kwapangitsa kuti BMT ipange chozizwitsa china. Junaid ndi wodwala wachiwiri wa B-lymphocytic leukaemia wobwerera m'mbuyo komanso wosachira wochokera ku Pakistan kulandira chithandizo cha CAR-T Bridge BMT. Kutuluka bwino kwa Junaid kuchipatalachi kwawonetsanso kudziwika padziko lonse lapansi kwa ukadaulo wapamwamba wa chipatala chathu wosinthira mlatho wa CAR-T.