Munthu wodzipereka wochokera ku India akulimbana ndi khansa ya m'mimba

Pali mwamuna wolimba mtima dzina lake Thirandas Shiva Prasad. Ali ndi zaka 32, ndipo amachokera ku India. N’chifukwa chiyani tikugogomezera kutsimikiza mtima kwake? Nayi nkhani yake yodabwitsa.

Thirandas adapezeka ndi khansa ya m'mimba mu 2023, akumva kupweteka m'mimba ndipo adatsimikiziridwa kuti ndi adenocarcinoma ya signet ring cell yotsika kwambiri. Adachitidwa chemotherapy ya neoadjuvant ndi FLOT regimen, kenako adachitidwa opaleshoni kuphatikizapo subtotal gastrectomy. Ngakhale kuti adalandira chithandizo pambuyo pa opaleshoni, khansayo idabwereranso ndi metastases m'chiuno, zomwe zidayambitsa mavuto monga hydronephrosis, abscesses, ndi obstructions. Adalandira njira zingapo, kuphatikizapo dialysis, stenting, ndi chemo ina ndi nab-paclitaxel, nivolumab, irinotecan, ndi zina. Pofika mu 2025, PET-CT scans idawonetsa kupita patsogolo ndi zilonda zam'mimba ndi ascites zomwe zidamupangitsa kufunikira njira zatsopano.

Pofuna chithandizo chamakono, Thirandas anatembenukira ku BIOOCUS. Gulu lathu la akatswiri linapereka mayeso oyamba kwaulere, kuwunikanso mbiri yake yayitali ndikulimbikitsa chithandizo cha maselo a CLDN18.2 CAR-T, chopangidwa kuti chigwirizane ndi mawonekedwe a chotupa chake. Pambuyo pochira, kulowetsedwako kunachitidwa bwino m'chipatala chathu chapamwamba. Ngakhale kuti panali zovuta zoyambirira monga malungo ndi matenda omwe angakhalepo, gulu lathu la akatswiri osiyanasiyana linathetsa zizindikiro bwino ndi maantibayotiki ndi chithandizo chothandizira, kuonetsetsa kuti palibe CRS yoopsa. Njira monga kutulutsa madzi m'mimba ndi kusintha kwa stent zinachitidwa molondola, zomwe zinapangitsa kuti zizindikirozo zichepe komanso zotsatira zabwino za matenda pambuyo pa chithandizo.

BIOOCUS imadziwika bwino chifukwa cha ntchito zake zapamwamba komanso zinthu zatsopano. Chithandizo chathu cha CAR-T, chomwe chimayang'ana CLDN18.2, chimapereka chithandizo cholunjika pa maselo a khansa, nthawi zambiri chimagwira ntchito bwino pamene njira zochiritsira zachikhalidwe zalephera. Ogwira ntchito odwala amachita bwino kwambiri pogwirizanitsa maulendo apadziko lonse lapansi, kupereka chisamaliro cha chikhalidwe, komanso kupereka malangizo okwanira, zonse popanda kuvutitsa. Thirandas amayamikira antchito achifundo komanso njira zogwira mtima zomwe zinasintha chochitika choopsa kukhala chiyembekezo.