Kupambana kwa Madhavan: Kugonjetsa Ubongo wa Glioma ndi Chithandizo cha Bioocus B7H3 CAR-T

Mbiri ya Odwala

Madhavan anapezeka ndi matenda a glioma muubongo, chotupa choipa chomwe chimadziwika kuti chimafalikira komanso kuti sichingathe kuonekera bwino. Ali ndi zaka 58, atalandira chithandizo chamankhwala chodziwika bwino kuphatikizapo opaleshoni ndi radiation, adapita ku Bioocus kuti akapeze njira zina zamakono. Atatumizidwa ku Tianjin Tumor Hospital Konggang Hospital, adalembetsa mu pulogalamu yathu ya B7H3 CAR-T pansi pa nambala ya chithandizo P001. B7H3 imafalikira kwambiri pa maselo a glioma, zomwe zimapangitsa kuti ikhale chandamale chabwino kwambiri cha maselo a T opangidwa omwe amaperekedwa kudzera mu cerebrospinal fluid (CSF) kuti amenyane ndi chotupacho mwachindunji.

Ulendo wa Chithandizo

Chithandizo cha Madhavan chinaphatikizapo kulowetsa maselo a CAR-T mu CSF, ndi kuyang'aniridwa kudzera mu kusanthula kwa CSF kuyambira Tsiku 2 (D2) mpaka Tsiku 28 (D28).

• D2 (Ogasiti 8, 2025):Kupezeka koyamba kwa B7H3 CAR-T pa 54.44% ya maselo a CD3+ T.
• D4 (Ogasiti 11, 2025):52%, kusonyeza kusintha kwa zinthu koyambirira.
• D7 (Ogasiti 14, 2025):Yakwera kufika pa 59.51%.
• D10 (Ogasiti 17, 2025):12%.
• D14 (Ogasiti 21, 2025):19%.
• D21 (Ogasiti 28, 2025):Inafika pachimake pa 89.69%, zomwe zikusonyeza kukula kwakukulu.
• D28 (Seputembala 6, 2025):Yakhazikika pa 13.58% ya maselo a CD3+ T, ndi 11.90% mu CD4+ ndi 14.28% mu maselo a CD8+. Ponseponse, maselo a CD3+ T adakula pa 95.34%, ndipo CD8+ yochuluka (66.74%) ikuwonetsa poizoni wamphamvu.

Ma graph okulitsa akuwonetsa kusinthasintha koma kupirira kwamphamvu kwa CAR-T, kofunikira kwambiri kuti chotupa chizilamulira CNS nthawi zonse.

Zotsatira Zabwino Kwambiri

Kuwonjezeka kwakukulu kwa D21 kunagwirizana ndi kuchepa kwa chotupa pa MRI, zomwe zinapangitsa kuti D28 iyankhidwe pang'ono komanso kuti zinthu zipitirire kusintha. Kupereka kumeneku mkati mwa thupi kumachepetsa zotsatira zoyipa za thupi komanso kumawonjezera mphamvu yolimbana ndi ma glioma, ndipo deta yathu ikuwonetsa kupulumuka kosapitirira muyeso. Madhavan adanenanso kuti zizindikiro zake sizingathetsedwe komanso kuti palibe poizoni woopsa wa mitsempha.