Uloyiso lukaMadhavan: Ukoyisa iBrain Glioma ngeBioocus B7H3 CAR-T Therapy

Imvelaphi yesigulane

UMadhavan wafunyaniswa ukuba une-brain glioma, ithumba elibi elaziwa ngokungena kwalo kunye nokungafumani iziphumo ezichanekileyo. Kwiminyaka engama-58 ubudala, emva kokuba unyango oluqhelekileyo oluquka utyando kunye nokusasazwa kwemitha lungaphumelelanga, wabhenela kwiBioocus ukuze afumane iindlela eziphambili. Wathunyelwa kwiSibhedlele saseTianjin Tumor Hospital Konggang, wabhalisa kwinkqubo yethu ye-B7H3 CAR-T phantsi konyango lwenombolo P001. I-B7H3 ibonakaliswa kakhulu kwiiseli ze-glioma, nto leyo eyenza ukuba ibe yindawo efanelekileyo kwiiseli ze-T ezakhiweyo ezilawulwa ngolwelo lwe-cerebrospinal (CSF) ukuhlasela ngokuthe ngqo ithumba.

Uhambo Lonyango

Unyango lukaMadhavan lwaluquka ukufaka iiseli ze-CAR-T ezizii-autologous kwi-CSF, kunye nokubeka iliso ngokusebenzisa uhlalutyo lwe-CSF olulandelelanayo ukusuka kwiSuku lesi-2 (D2) ukuya kwiSuku lama-28 (D28).

• D2 (nge-8 ka-Agasti, 2025):Ubukho bokuqala obuqinileyo kunye ne-B7H3 CAR-T kwi-54.44% yeeseli ze-CD3+ T.
• D4 (nge-11 ka-Agasti, 2025):52%, ebonisa amandla okuqala.
• D7 (nge-14 ka-Agasti, 2025):Inyuke yaya kwi-59.51%.
• D10 (nge-17 ka-Agasti, 2025):12%.
• D14 (nge-21 ka-Agasti, 2025):19%.
• D21 (nge-28 ka-Agasti, 2025):Ifikelele kwinqanaba eliphezulu kwi-89.69%, nto leyo ebonisa ukwanda okugqwesileyo.
• D28 (nge-6 kaSeptemba, 2025):Izinzile kwi-13.58% yeeseli ze-CD3+ T, kunye ne-11.90% kwi-CD4+ kunye ne-14.28% kwiiseti ze-CD8+. Lilonke, iiseli ze-CD3+ T zikhokelele kwi-95.34%, kunye ne-CD8+ ephezulu (66.74%) ebonisa ubuthi obunamandla.

Iigrafu zokwandiswa zibonisa ukuqina kwe-CAR-T okuguqukayo kodwa okuqinileyo ngokubanzi, kubalulekile ekulawuleni ithumba eliqhubekayo kwi-CNS.

Iziphumo Ezibalaseleyo

Ukwanda okuphezulu kwi-D21 kunxulumene nokuncipha kwethumba kwi-MRI, nto leyo ekhokelela kwimpendulo engaphelelanga yi-D28 kunye nokuphucuka okuqhubekayo. Oku kuhanjiswa ngaphakathi kwe-thecal kunciphisa iziphumo ebezingalindelekanga kwinkqubo yomzimba ngelixa kwandisa ukusebenza kakuhle ngokuchasene ne-gliomas, kunye nedatha yethu ebonisa ukusinda okuphuculweyo okungenankqubela phambili. UMadhavan uxele ngeempawu ezilawulekayo kunye nokungabikho kwetyhefu enkulu ye-neurological.